Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks

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Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks. / Proshina, Ekaterina A.; Savostyanov, Alexander N.; Bocharov, Andrey V. et al.

In: Brain Research, Vol. 1697, 15.10.2018, p. 67-75.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{906a660b2a564e11bd8b50bdbfd3deb5,

title = "Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks",

abstract = "The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual variation in electrophysiological properties of resting state brain networks is very limited. This study investigated the effect of 5-HTTLPR polymorphism on EEG current source density, connectivity, and topological properties of resting state networks. We collected genetic and resting state EEG data in 113 Caucasians. As compared to L-homozygotes, S-allele carriers showed lower current source density and connectivity in most frequency bands in areas overlapping with the default mode and emotion regulation regions. The analysis of graph-theoretical measures showed that S-allele carriers, as compared to L-homozygotes, have less optimal topological properties of brain networks in theta, but more optimal in alpha band. This dissociation may reflect the predisposition to emotional disorders, which is inherent to S-allele carriers, and, on the other hand, their superior functioning in some cognitive domains.",

keywords = "5-HTTLPR, Connectivity, EEG, Graph theory, Resting state, sLORETA, DEFAULT MODE NETWORK, COGNITIVE PERFORMANCE, ALZHEIMERS-DISEASE, FUNCTIONAL CONNECTIVITY, SEROTONIN TRANSPORTER GENE, EMOTIONAL STIMULI, POLYMORPHISM 5-HTTLPR, STRESSFUL LIFE EVENTS, CORTICAL THICKNESS, BRAIN NETWORKS, Humans, Male, Rest/physiology, Connectome/methods, Young Adult, Serotonin Plasma Membrane Transport Proteins/genetics, Adult, Cerebral Cortex/physiology, Female, Neural Pathways/metabolism, Electroencephalography/methods, Gene Frequency, Brain/physiology, Genotype, Polymorphism, Genetic/genetics, Membrane Potentials, Electrophysiological Phenomena",

author = "Proshina, {Ekaterina A.} and Savostyanov, {Alexander N.} and Bocharov, {Andrey V.} and Knyazev, {Gennady G.}",

year = "2018",

month = oct,

day = "15",

doi = "10.1016/j.brainres.2018.06.018",

language = "English",

volume = "1697",

pages = "67--75",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Effect of 5-HTTLPR on current source density, connectivity, and topological properties of resting state EEG networks

AU - Proshina, Ekaterina A.

AU - Savostyanov, Alexander N.

AU - Bocharov, Andrey V.

AU - Knyazev, Gennady G.

PY - 2018/10/15

Y1 - 2018/10/15

N2 - The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual variation in electrophysiological properties of resting state brain networks is very limited. This study investigated the effect of 5-HTTLPR polymorphism on EEG current source density, connectivity, and topological properties of resting state networks. We collected genetic and resting state EEG data in 113 Caucasians. As compared to L-homozygotes, S-allele carriers showed lower current source density and connectivity in most frequency bands in areas overlapping with the default mode and emotion regulation regions. The analysis of graph-theoretical measures showed that S-allele carriers, as compared to L-homozygotes, have less optimal topological properties of brain networks in theta, but more optimal in alpha band. This dissociation may reflect the predisposition to emotional disorders, which is inherent to S-allele carriers, and, on the other hand, their superior functioning in some cognitive domains.

AB - The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual variation in electrophysiological properties of resting state brain networks is very limited. This study investigated the effect of 5-HTTLPR polymorphism on EEG current source density, connectivity, and topological properties of resting state networks. We collected genetic and resting state EEG data in 113 Caucasians. As compared to L-homozygotes, S-allele carriers showed lower current source density and connectivity in most frequency bands in areas overlapping with the default mode and emotion regulation regions. The analysis of graph-theoretical measures showed that S-allele carriers, as compared to L-homozygotes, have less optimal topological properties of brain networks in theta, but more optimal in alpha band. This dissociation may reflect the predisposition to emotional disorders, which is inherent to S-allele carriers, and, on the other hand, their superior functioning in some cognitive domains.

KW - 5-HTTLPR

KW - Connectivity

KW - EEG

KW - Graph theory

KW - Resting state

KW - sLORETA

KW - DEFAULT MODE NETWORK

KW - COGNITIVE PERFORMANCE

KW - ALZHEIMERS-DISEASE

KW - FUNCTIONAL CONNECTIVITY

KW - SEROTONIN TRANSPORTER GENE

KW - EMOTIONAL STIMULI

KW - POLYMORPHISM 5-HTTLPR

KW - STRESSFUL LIFE EVENTS

KW - CORTICAL THICKNESS

KW - BRAIN NETWORKS

KW - Humans

KW - Male

KW - Rest/physiology

KW - Connectome/methods

KW - Young Adult

KW - Serotonin Plasma Membrane Transport Proteins/genetics

KW - Adult

KW - Cerebral Cortex/physiology

KW - Female

KW - Neural Pathways/metabolism

KW - Electroencephalography/methods

KW - Gene Frequency

KW - Brain/physiology

KW - Genotype

KW - Polymorphism, Genetic/genetics

KW - Membrane Potentials

KW - Electrophysiological Phenomena

UR - http://www.scopus.com/inward/record.url?scp=85048706565&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2018.06.018

DO - 10.1016/j.brainres.2018.06.018

M3 - Article

C2 - 29913130

AN - SCOPUS:85048706565

VL - 1697

SP - 67

EP - 75

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -

ID: 14046954