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Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine. / Drozd, U. S.; Lanshakov, D. A.; Dygalo, N. N.

In: Neurochemical Journal, Vol. 17, No. 3, 2023, p. 394-401.

Research output: Contribution to journal › Article › peer-review

Harvard

Drozd, US, Lanshakov, DA & Dygalo, NN 2023, 'Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine', Neurochemical Journal, vol. 17, no. 3, pp. 394-401. https://doi.org/10.1134/s181971242303008x

APA

Drozd, U. S., Lanshakov, D. A., & Dygalo, N. N. (2023). Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine. Neurochemical Journal, 17(3), 394-401. https://doi.org/10.1134/s181971242303008x

Vancouver

Drozd US, Lanshakov DA, Dygalo NN. Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine. Neurochemical Journal. 2023;17(3):394-401. doi: 10.1134/s181971242303008x

Author

Drozd, U. S. ; Lanshakov, D. A. ; Dygalo, N. N. / Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine. In: Neurochemical Journal. 2023 ; Vol. 17, No. 3. pp. 394-401.

BibTeX

@article{fb561b90c9c84acfa523649ff841b981,
title = "Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine",
abstract = "The mechanisms of the ketamine antidepressant effects observed in humans and laboratory animals are not fully understood. To further clarify the role of brain serotonergic (5-HT) activity in the action of antidepressant drugs, optogenetic inhibition of 5-HT neurons in the rat dorsal raphe nucleus (DRN) was applied. In control animals, a subanesthetic dose of ketamine alleviated their depressive-like behavior in the tail suspension test. Inhibition of 5-HT neurons abolished the drug effect and moreover, a sedative response to ketamine was found under these conditions. Furthermore, optogenetic suppression of the activity of 5-HT neurons prevented the increase in c-Fos expression induced by ketamine both in light-sensitive neurons and in other DRN neurons. The data emphasize the key role of 5-HT neuron activity in the rapid ketamine antidepressant effect. ",
keywords = "KETAMINE, DEPRESSION-LIKE BEHAVIOR, TAIL SUSPENSION TEST, 5-HT, DORSAL RAPHE NUCLEUS, OPTOGENETICS, EARCHT3.0, LENTIVIRAL VECTOR,, C-FOS PROTEIN, NEUROSCIENCES",
author = "Drozd, {U. S.} and Lanshakov, {D. A.} and Dygalo, {N. N.}",
note = "Drozd, U. S. Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine / U. S. Drozd, D. A. Lanshakov, N. N. Dygalo // Neurochemical Journal. – 2023. – Vol. 17, No. 3. – P. 394-401. – DOI 10.1134/s181971242303008x.",
year = "2023",
doi = "10.1134/s181971242303008x",
language = "English",
volume = "17",
pages = "394--401",
journal = "Neurochemical Journal",
issn = "1819-7124",
publisher = "Общество с ограниченной ответственностью Международная академическая издательская компания {"}Наука/Интерпериодика{"}",
number = "3",

}

RIS

TY - JOUR

T1 - Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine

AU - Drozd, U. S.

AU - Lanshakov, D. A.

AU - Dygalo, N. N.

N1 - Drozd, U. S. Dorsal Raphe Nucleus Serotonergic Neuron Activity is Necessary for the Manifestation of the Antidepressant Effect of Ketamine / U. S. Drozd, D. A. Lanshakov, N. N. Dygalo // Neurochemical Journal. – 2023. – Vol. 17, No. 3. – P. 394-401. – DOI 10.1134/s181971242303008x.

PY - 2023

Y1 - 2023

N2 - The mechanisms of the ketamine antidepressant effects observed in humans and laboratory animals are not fully understood. To further clarify the role of brain serotonergic (5-HT) activity in the action of antidepressant drugs, optogenetic inhibition of 5-HT neurons in the rat dorsal raphe nucleus (DRN) was applied. In control animals, a subanesthetic dose of ketamine alleviated their depressive-like behavior in the tail suspension test. Inhibition of 5-HT neurons abolished the drug effect and moreover, a sedative response to ketamine was found under these conditions. Furthermore, optogenetic suppression of the activity of 5-HT neurons prevented the increase in c-Fos expression induced by ketamine both in light-sensitive neurons and in other DRN neurons. The data emphasize the key role of 5-HT neuron activity in the rapid ketamine antidepressant effect.

AB - The mechanisms of the ketamine antidepressant effects observed in humans and laboratory animals are not fully understood. To further clarify the role of brain serotonergic (5-HT) activity in the action of antidepressant drugs, optogenetic inhibition of 5-HT neurons in the rat dorsal raphe nucleus (DRN) was applied. In control animals, a subanesthetic dose of ketamine alleviated their depressive-like behavior in the tail suspension test. Inhibition of 5-HT neurons abolished the drug effect and moreover, a sedative response to ketamine was found under these conditions. Furthermore, optogenetic suppression of the activity of 5-HT neurons prevented the increase in c-Fos expression induced by ketamine both in light-sensitive neurons and in other DRN neurons. The data emphasize the key role of 5-HT neuron activity in the rapid ketamine antidepressant effect.

KW - KETAMINE

KW - DEPRESSION-LIKE BEHAVIOR

KW - TAIL SUSPENSION TEST

KW - 5-HT

KW - DORSAL RAPHE NUCLEUS

KW - OPTOGENETICS

KW - EARCHT3.0

KW - LENTIVIRAL VECTOR,

KW - C-FOS PROTEIN

KW - NEUROSCIENCES

UR - https://www.mendeley.com/catalogue/1afa6b0f-0d46-3313-93b4-ed34fa2f6b9f/

UR - https://www.elibrary.ru/item.asp?id=62876157

U2 - 10.1134/s181971242303008x

DO - 10.1134/s181971242303008x

M3 - Article

VL - 17

SP - 394

EP - 401

JO - Neurochemical Journal

JF - Neurochemical Journal

SN - 1819-7124

IS - 3

ER -

ID: 68317041