Research output: Contribution to journal › Article › peer-review
DNA Base Editors Are a Promising Tool for Gene Therapy of Human Viral Infections. / Aliev, T. I.; Imatdinov, I. R.
In: Molecular Genetics, Microbiology and Virology, Vol. 40, No. 3, 1, 09.2025, p. 155-159.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - DNA Base Editors Are a Promising Tool for Gene Therapy of Human Viral Infections
AU - Aliev, T. I.
AU - Imatdinov, I. R.
N1 - DNA Base Editors Are a Promising Tool for Gene Therapy of Human Viral Infections / T. I. Aliev, I. R. Imatdinov // Molecular Genetics, Microbiology and Virology. – 2025. – Vol. 40. - No. 3. – P. 155-159. – DOI 10.3103/S089141682570017X. – EDN QQJDPI. This study was supported by the Ministry of Science and Higher Education of the Russian Federation, “Federal Science and Technical Program for the Development of Genetic Technology (2019—2030),” agreement no. 075-15-2025-526.
PY - 2025/9
Y1 - 2025/9
N2 - The use of base editors has been a significant achievement in the field of genomic editing. This approach involves the point-by-point editing of nitrogenous bases in the DNA of living cells. Since such an editing method does not involve the introduction of double-stranded breaks, such as the widespread CRISPR-Cas method, base editors are a promising tool in gene therapy by temporarily altering RNA bases or permanently altering DNA bases. Recent advances in the specificity, effectiveness, accuracy, and delivery of base editors open up new therapeutic possibilities for these technologies. It is assumed that the correction of single nucleotide mutations will become one of the directions of future precision medicine.
AB - The use of base editors has been a significant achievement in the field of genomic editing. This approach involves the point-by-point editing of nitrogenous bases in the DNA of living cells. Since such an editing method does not involve the introduction of double-stranded breaks, such as the widespread CRISPR-Cas method, base editors are a promising tool in gene therapy by temporarily altering RNA bases or permanently altering DNA bases. Recent advances in the specificity, effectiveness, accuracy, and delivery of base editors open up new therapeutic possibilities for these technologies. It is assumed that the correction of single nucleotide mutations will become one of the directions of future precision medicine.
KW - adenine base editor
KW - cytosine base editor
KW - gene therapy
KW - review
KW - viral infections
KW - ОБЗОР
KW - РЕДАКТОР ОСНОВАНИЙ ЦИТОЗИНА
KW - РЕДАКТОР ОСНОВАНИЙ АДЕНИНА
KW - ГЕННАЯ ТЕРАПИЯ
KW - ВИРУСНЫЕ ИНФЕКЦИИ
UR - https://www.scopus.com/pages/publications/105026045605
UR - https://www.elibrary.ru/item.asp?id=87368354
UR - https://www.elibrary.ru/item.asp?id=82972004
UR - https://www.mendeley.com/catalogue/a77c7b5b-a75f-30fe-9951-c5c36475e7b9/
U2 - 10.3103/S089141682570017X
DO - 10.3103/S089141682570017X
M3 - Article
VL - 40
SP - 155
EP - 159
JO - Molecular Genetics, Microbiology and Virology
JF - Molecular Genetics, Microbiology and Virology
SN - 0891-4168
IS - 3
M1 - 1
ER -
ID: 75443806