Standard

Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel. / Meteleva, Elizaveta S.; Chistyachenko, Yulia S.; Suntsova, Lyubov P. et al.

In: Journal of Drug Delivery Science and Technology, Vol. 50, 01.04.2019, p. 66-77.

Research output: Contribution to journalArticlepeer-review

Harvard

Meteleva, ES, Chistyachenko, YS, Suntsova, LP, Khvostov, MV, Polyakov, NE, Selyutina, OY, Tolstikova, TG, Frolova, TS, Mordvinov, VA, Dushkin, AV & Lyakhov, NZ 2019, 'Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel', Journal of Drug Delivery Science and Technology, vol. 50, pp. 66-77. https://doi.org/10.1016/j.jddst.2019.01.014

APA

Meteleva, E. S., Chistyachenko, Y. S., Suntsova, L. P., Khvostov, M. V., Polyakov, N. E., Selyutina, O. Y., Tolstikova, T. G., Frolova, T. S., Mordvinov, V. A., Dushkin, A. V., & Lyakhov, N. Z. (2019). Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel. Journal of Drug Delivery Science and Technology, 50, 66-77. https://doi.org/10.1016/j.jddst.2019.01.014

Vancouver

Meteleva ES, Chistyachenko YS, Suntsova LP, Khvostov MV, Polyakov NE, Selyutina OY et al. Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel. Journal of Drug Delivery Science and Technology. 2019 Apr 1;50:66-77. doi: 10.1016/j.jddst.2019.01.014

Author

Meteleva, Elizaveta S. ; Chistyachenko, Yulia S. ; Suntsova, Lyubov P. et al. / Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel. In: Journal of Drug Delivery Science and Technology. 2019 ; Vol. 50. pp. 66-77.

BibTeX

@article{b6f6eaf3956e48df8b9f4f18def9c7b0,
title = "Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel",
abstract = "The aim of the study was to enhance the solubility and bioavailability of praziquantel (PZQ) through mechanochemical preparation of its solid compositions with the disodium salt of glycyrrhizic acid (Na2GA). The compositions were studied in the solid phase by means of scanning electron microscopy, powder X-ray diffraction and thermal analysis, and in solutions by means of HPLC, gel permeation chromatography, phase solubility assay and 1H NMR spectroscopy. PZQ permeability was studied by means of parallel artificial membrane permeability assay and with a monolayer of Caco-2 cells. The pharmacokinetic characteristics and acute toxicity of PZQ and its compositions were studied on mice. Solubility of PZQ in the compositions increases up to 3.5 times. The micelles in Na2GA solutions possess a molecular mass of ∼60 kDa. An increase in PZQ solubility may be due to its inclusion into micelles of glycyrrhizic acid. The permeability of PZQ was found to be much higher from its composition with Na2GA in comparison with initial PZQ. An increase in PZQ bioavailability by a factor of 3 in laboratory mice and changes of pharmacokinetic curve shape were demonstrated for the oral administration of its composition with Na2GA. The solid compositions show high chemical stability under rapid storage test. The obtained PZQ compositions may be a promising basis for the development of anthelmintic preparations with increased efficiency.",
keywords = "Drug delivery, Glycyrrhizic acid, Intermolecular interactions, Mechanochemistry, Micelles, Praziquantel, Solubility enhancement, PERMEABILITY, SCHISTOSOMA-MANSONI, SOLID DISPERSION, ALBENDAZOLE, BIOAVAILABILITY, IN-VITRO, DISSOLUTION, ENHANCEMENT, ABSORPTION, POLYSACCHARIDE ARABINOGALACTAN",
author = "Meteleva, {Elizaveta S.} and Chistyachenko, {Yulia S.} and Suntsova, {Lyubov P.} and Khvostov, {Mikhail V.} and Polyakov, {Nikolay E.} and Selyutina, {Olga Yu} and Tolstikova, {Tatyana G.} and Frolova, {Tatyana S.} and Mordvinov, {Viatcheslav A.} and Dushkin, {Alexander V.} and Lyakhov, {Nikolay Z.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",
year = "2019",
month = apr,
day = "1",
doi = "10.1016/j.jddst.2019.01.014",
language = "English",
volume = "50",
pages = "66--77",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Editions de Sante",

}

RIS

TY - JOUR

T1 - Disodium salt of glycyrrhizic acid – A novel supramolecular delivery system for anthelmintic drug praziquantel

AU - Meteleva, Elizaveta S.

AU - Chistyachenko, Yulia S.

AU - Suntsova, Lyubov P.

AU - Khvostov, Mikhail V.

AU - Polyakov, Nikolay E.

AU - Selyutina, Olga Yu

AU - Tolstikova, Tatyana G.

AU - Frolova, Tatyana S.

AU - Mordvinov, Viatcheslav A.

AU - Dushkin, Alexander V.

AU - Lyakhov, Nikolay Z.

N1 - Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The aim of the study was to enhance the solubility and bioavailability of praziquantel (PZQ) through mechanochemical preparation of its solid compositions with the disodium salt of glycyrrhizic acid (Na2GA). The compositions were studied in the solid phase by means of scanning electron microscopy, powder X-ray diffraction and thermal analysis, and in solutions by means of HPLC, gel permeation chromatography, phase solubility assay and 1H NMR spectroscopy. PZQ permeability was studied by means of parallel artificial membrane permeability assay and with a monolayer of Caco-2 cells. The pharmacokinetic characteristics and acute toxicity of PZQ and its compositions were studied on mice. Solubility of PZQ in the compositions increases up to 3.5 times. The micelles in Na2GA solutions possess a molecular mass of ∼60 kDa. An increase in PZQ solubility may be due to its inclusion into micelles of glycyrrhizic acid. The permeability of PZQ was found to be much higher from its composition with Na2GA in comparison with initial PZQ. An increase in PZQ bioavailability by a factor of 3 in laboratory mice and changes of pharmacokinetic curve shape were demonstrated for the oral administration of its composition with Na2GA. The solid compositions show high chemical stability under rapid storage test. The obtained PZQ compositions may be a promising basis for the development of anthelmintic preparations with increased efficiency.

AB - The aim of the study was to enhance the solubility and bioavailability of praziquantel (PZQ) through mechanochemical preparation of its solid compositions with the disodium salt of glycyrrhizic acid (Na2GA). The compositions were studied in the solid phase by means of scanning electron microscopy, powder X-ray diffraction and thermal analysis, and in solutions by means of HPLC, gel permeation chromatography, phase solubility assay and 1H NMR spectroscopy. PZQ permeability was studied by means of parallel artificial membrane permeability assay and with a monolayer of Caco-2 cells. The pharmacokinetic characteristics and acute toxicity of PZQ and its compositions were studied on mice. Solubility of PZQ in the compositions increases up to 3.5 times. The micelles in Na2GA solutions possess a molecular mass of ∼60 kDa. An increase in PZQ solubility may be due to its inclusion into micelles of glycyrrhizic acid. The permeability of PZQ was found to be much higher from its composition with Na2GA in comparison with initial PZQ. An increase in PZQ bioavailability by a factor of 3 in laboratory mice and changes of pharmacokinetic curve shape were demonstrated for the oral administration of its composition with Na2GA. The solid compositions show high chemical stability under rapid storage test. The obtained PZQ compositions may be a promising basis for the development of anthelmintic preparations with increased efficiency.

KW - Drug delivery

KW - Glycyrrhizic acid

KW - Intermolecular interactions

KW - Mechanochemistry

KW - Micelles

KW - Praziquantel

KW - Solubility enhancement

KW - PERMEABILITY

KW - SCHISTOSOMA-MANSONI

KW - SOLID DISPERSION

KW - ALBENDAZOLE

KW - BIOAVAILABILITY

KW - IN-VITRO

KW - DISSOLUTION

KW - ENHANCEMENT

KW - ABSORPTION

KW - POLYSACCHARIDE ARABINOGALACTAN

UR - http://www.scopus.com/inward/record.url?scp=85060074289&partnerID=8YFLogxK

U2 - 10.1016/j.jddst.2019.01.014

DO - 10.1016/j.jddst.2019.01.014

M3 - Article

AN - SCOPUS:85060074289

VL - 50

SP - 66

EP - 77

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

ER -

ID: 18291229