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Discrepancy between thermodynamic and kinetic stabilities of the : Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. / Ogienko, A. G.; Stoporev, A. S.; Ogienko, A. A. et al.

In: Chemical Communications, Vol. 55, No. 29, 17.04.2019, p. 4262-4265.

Research output: Contribution to journal › Article › peer-review

Harvard

Ogienko, AG, Stoporev, AS, Ogienko, AA, Mel'Gunov, MS, Adamova, TP, Yunoshev, AS, Manakov, AY & Boldyreva, EV 2019, 'Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying', Chemical Communications, vol. 55, no. 29, pp. 4262-4265. https://doi.org/10.1039/c9cc00397e

APA

Ogienko, A. G., Stoporev, A. S., Ogienko, A. A., Mel'Gunov, M. S., Adamova, T. P., Yunoshev, A. S., Manakov, A. Y., & Boldyreva, E. V. (2019). Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. Chemical Communications, 55(29), 4262-4265. https://doi.org/10.1039/c9cc00397e

Vancouver

Ogienko AG, Stoporev AS, Ogienko AA, Mel'Gunov MS, Adamova TP, Yunoshev AS et al. Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. Chemical Communications. 2019 Apr 17;55(29):4262-4265. doi: 10.1039/c9cc00397e

Author

Ogienko, A. G. ; Stoporev, A. S. ; Ogienko, A. A. et al. / Discrepancy between thermodynamic and kinetic stabilities of the : Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. In: Chemical Communications. 2019 ; Vol. 55, No. 29. pp. 4262-4265.

BibTeX

@article{750bd90b450245df9e843b21954da373,
title = "Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying",
abstract = "The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).",
keywords = "Drug Stability, Freeze Drying, Kinetics, Powders, Thermodynamics, tert-Butyl Alcohol/chemistry, COSOLVENT SYSTEMS, DESIGN, BUTYL ALCOHOL, ICE NUCLEATION, LYOPHILIZATION, QUALITY ATTRIBUTES, PROCESS PERFORMANCE, PHASE-DIAGRAM",
author = "Ogienko, {A. G.} and Stoporev, {A. S.} and Ogienko, {A. A.} and Mel'Gunov, {M. S.} and Adamova, {T. P.} and Yunoshev, {A. S.} and Manakov, {A. Yu} and Boldyreva, {E. V.}",
note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
month = apr,
day = "17",
doi = "10.1039/c9cc00397e",
language = "English",
volume = "55",
pages = "4262--4265",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "29",

}

RIS

TY - JOUR

T1 - Discrepancy between thermodynamic and kinetic stabilities of the

T2 - Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

AU - Ogienko, A. G.

AU - Stoporev, A. S.

AU - Ogienko, A. A.

AU - Mel'Gunov, M. S.

AU - Adamova, T. P.

AU - Yunoshev, A. S.

AU - Manakov, A. Yu

AU - Boldyreva, E. V.

N1 - Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019/4/17

Y1 - 2019/4/17

N2 - The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

AB - The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

KW - Drug Stability

KW - Freeze Drying

KW - Kinetics

KW - Powders

KW - Thermodynamics

KW - tert-Butyl Alcohol/chemistry

KW - COSOLVENT SYSTEMS

KW - DESIGN

KW - BUTYL ALCOHOL

KW - ICE NUCLEATION

KW - LYOPHILIZATION

KW - QUALITY ATTRIBUTES

KW - PROCESS PERFORMANCE

KW - PHASE-DIAGRAM

UR - http://www.scopus.com/inward/record.url?scp=85064038707&partnerID=8YFLogxK

U2 - 10.1039/c9cc00397e

DO - 10.1039/c9cc00397e

M3 - Article

C2 - 30906942

AN - SCOPUS:85064038707

VL - 55

SP - 4262

EP - 4265

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 29

ER -

ID: 19357584