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Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor. / Sokolova, Anastasiya S.; Yarovaya, Olga I.; Bormotov, Nikolay I. et al.

In: Chemistry and Biodiversity, Vol. 15, No. 9, e1800153, 01.09.2018.

Research output: Contribution to journal › Article › peer-review

Harvard

Sokolova, AS, Yarovaya, OI, Bormotov, NI, Shishkina, LN & Salakhutdinov, NF 2018, 'Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor', Chemistry and Biodiversity, vol. 15, no. 9, e1800153. https://doi.org/10.1002/cbdv.201800153

APA

Sokolova, A. S., Yarovaya, O. I., Bormotov, N. I., Shishkina, L. N., & Salakhutdinov, N. F. (2018). Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor. Chemistry and Biodiversity, 15(9), [e1800153]. https://doi.org/10.1002/cbdv.201800153

Vancouver

Sokolova AS, Yarovaya OI, Bormotov NI, Shishkina LN, Salakhutdinov NF. Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor. Chemistry and Biodiversity. 2018 Sept 1;15(9):e1800153. doi: 10.1002/cbdv.201800153

Author

Sokolova, Anastasiya S. ; Yarovaya, Olga I. ; Bormotov, Nikolay I. et al. / Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor. In: Chemistry and Biodiversity. 2018 ; Vol. 15, No. 9.

BibTeX

@article{9d7b3f306ace47d9a316ea380fb0e701,
title = "Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor",
abstract = "A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.",
keywords = "antiviral activities, borneol, monoterpenoids, N-heterocycles, orthopoxviruses, TECOVIRIMAT, EFFICACY, BORNEOL DERIVATIVES, SMALLPOX, ORTHOPOXVIRUS INFECTIONS",
author = "Sokolova, {Anastasiya S.} and Yarovaya, {Olga I.} and Bormotov, {Nikolay I.} and Shishkina, {Larisa N.} and Salakhutdinov, {Nariman F.}",
year = "2018",
month = sep,
day = "1",
doi = "10.1002/cbdv.201800153",
language = "English",
volume = "15",
journal = "Chemistry and Biodiversity",
issn = "1612-1872",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor

AU - Sokolova, Anastasiya S.

AU - Yarovaya, Olga I.

AU - Bormotov, Nikolay I.

AU - Shishkina, Larisa N.

AU - Salakhutdinov, Nariman F.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.

AB - A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.

KW - antiviral activities

KW - borneol

KW - monoterpenoids

KW - N-heterocycles

KW - orthopoxviruses

KW - TECOVIRIMAT

KW - EFFICACY

KW - BORNEOL DERIVATIVES

KW - SMALLPOX

KW - ORTHOPOXVIRUS INFECTIONS

UR - http://www.scopus.com/inward/record.url?scp=85052525434&partnerID=8YFLogxK

U2 - 10.1002/cbdv.201800153

DO - 10.1002/cbdv.201800153

M3 - Article

AN - SCOPUS:85052525434

VL - 15

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

SN - 1612-1872

IS - 9

M1 - e1800153

ER -

ID: 16242555