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Differential alternative splicing in brain regions of rats selected for aggressive behavior. / Babenko, V. N.; Bragin, A. O.; Chadaeva, I. V. et al.

In: Molecular Biology, Vol. 51, No. 5, 01.09.2017, p. 759-768.

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Babenko VN, Bragin AO, Chadaeva IV, Markel AL, Orlov YL. Differential alternative splicing in brain regions of rats selected for aggressive behavior. Molecular Biology. 2017 Sept 1;51(5):759-768. doi: 10.1134/S002689331705003X

Author

Babenko, V. N. ; Bragin, A. O. ; Chadaeva, I. V. et al. / Differential alternative splicing in brain regions of rats selected for aggressive behavior. In: Molecular Biology. 2017 ; Vol. 51, No. 5. pp. 759-768.

BibTeX

@article{19b542c7cd214a06a846059e7c6af02e,
title = "Differential alternative splicing in brain regions of rats selected for aggressive behavior",
abstract = "Profiles of alternative mRNA isoforms have been determined in three brain regions of rats from an aggressive and a tame line selected for 74 generations. Among 2319 genes with alternatively spliced exons, approximately 84% were confirmed by analyzing public databases. Based on Gene Ontology-guided clustering of alternatively spliced genes, it has been found that the sample was enriched in synapse-specific genes (FDR < 10–17). Patterns of gene expression in the brains of animals with genetically determined high or low aggression were more frequently found to differ in the use of alternatively spliced exons than in animals environmentally conditioned for increased or lowered propensity to aggression. For the Adcyap1r1 gene, five alternatively spliced mRNA isoforms have been represented differentially in aggressive animals. A detailed analysis of the gene that encodes glutamate ionotropic receptor NMDA type subunit 1 (Grin1) has confirmed significant differences in the levels of its alternatively spliced isoforms in certain brain regions of tame and aggressive rats. These differences may affect the behavior in rats genetically selected for aggression levels.",
keywords = "aggressive behavior, alternative splicing, Grin1, RNA profiling, synaptic conduction genes, NMDA RECEPTOR, MOLECULAR-BIOLOGY, PROTEIN, VARIANTS, MESSENGER-RNA, GENE-EXPRESSION, OPEN-FIELD TEST, NR1 SUBUNIT, REVEALS",
author = "Babenko, {V. N.} and Bragin, {A. O.} and Chadaeva, {I. V.} and Markel, {A. L.} and Orlov, {Y. L.}",
note = "Publisher Copyright: {\textcopyright} 2017, Pleiades Publishing, Inc.",
year = "2017",
month = sep,
day = "1",
doi = "10.1134/S002689331705003X",
language = "English",
volume = "51",
pages = "759--768",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "5",

}

RIS

TY - JOUR

T1 - Differential alternative splicing in brain regions of rats selected for aggressive behavior

AU - Babenko, V. N.

AU - Bragin, A. O.

AU - Chadaeva, I. V.

AU - Markel, A. L.

AU - Orlov, Y. L.

N1 - Publisher Copyright: © 2017, Pleiades Publishing, Inc.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Profiles of alternative mRNA isoforms have been determined in three brain regions of rats from an aggressive and a tame line selected for 74 generations. Among 2319 genes with alternatively spliced exons, approximately 84% were confirmed by analyzing public databases. Based on Gene Ontology-guided clustering of alternatively spliced genes, it has been found that the sample was enriched in synapse-specific genes (FDR < 10–17). Patterns of gene expression in the brains of animals with genetically determined high or low aggression were more frequently found to differ in the use of alternatively spliced exons than in animals environmentally conditioned for increased or lowered propensity to aggression. For the Adcyap1r1 gene, five alternatively spliced mRNA isoforms have been represented differentially in aggressive animals. A detailed analysis of the gene that encodes glutamate ionotropic receptor NMDA type subunit 1 (Grin1) has confirmed significant differences in the levels of its alternatively spliced isoforms in certain brain regions of tame and aggressive rats. These differences may affect the behavior in rats genetically selected for aggression levels.

AB - Profiles of alternative mRNA isoforms have been determined in three brain regions of rats from an aggressive and a tame line selected for 74 generations. Among 2319 genes with alternatively spliced exons, approximately 84% were confirmed by analyzing public databases. Based on Gene Ontology-guided clustering of alternatively spliced genes, it has been found that the sample was enriched in synapse-specific genes (FDR < 10–17). Patterns of gene expression in the brains of animals with genetically determined high or low aggression were more frequently found to differ in the use of alternatively spliced exons than in animals environmentally conditioned for increased or lowered propensity to aggression. For the Adcyap1r1 gene, five alternatively spliced mRNA isoforms have been represented differentially in aggressive animals. A detailed analysis of the gene that encodes glutamate ionotropic receptor NMDA type subunit 1 (Grin1) has confirmed significant differences in the levels of its alternatively spliced isoforms in certain brain regions of tame and aggressive rats. These differences may affect the behavior in rats genetically selected for aggression levels.

KW - aggressive behavior

KW - alternative splicing

KW - Grin1

KW - RNA profiling

KW - synaptic conduction genes

KW - NMDA RECEPTOR

KW - MOLECULAR-BIOLOGY

KW - PROTEIN

KW - VARIANTS

KW - MESSENGER-RNA

KW - GENE-EXPRESSION

KW - OPEN-FIELD TEST

KW - NR1 SUBUNIT

KW - REVEALS

UR - http://www.scopus.com/inward/record.url?scp=85031420518&partnerID=8YFLogxK

U2 - 10.1134/S002689331705003X

DO - 10.1134/S002689331705003X

M3 - Article

AN - SCOPUS:85031420518

VL - 51

SP - 759

EP - 768

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 5

ER -

ID: 8798292