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Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement. / Kechin, A. A.; Koryukov, M. A.; Smertina, M. A. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 175, No. 1, 05.2023, p. 78-85.

Research output: Contribution to journal › Article › peer-review

Harvard

Kechin, AA, Koryukov, MA, Smertina, MA, Borobova, VS, Oscorbin, IP, Ivanov, AA, Bakharev, SY, Boyarskikh, UA, Kushlinskii, NE & Filipenko, ML 2023, 'Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement', Bulletin of Experimental Biology and Medicine, vol. 175, no. 1, pp. 78-85. https://doi.org/10.1007/s10517-023-05815-0

APA

Kechin, A. A., Koryukov, M. A., Smertina, M. A., Borobova, V. S., Oscorbin, I. P., Ivanov, A. A., Bakharev, S. Y., Boyarskikh, U. A., Kushlinskii, N. E., & Filipenko, M. L. (2023). Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement. Bulletin of Experimental Biology and Medicine, 175(1), 78-85. https://doi.org/10.1007/s10517-023-05815-0

Vancouver

Kechin AA, Koryukov MA, Smertina MA, Borobova VS, Oscorbin IP, Ivanov AA et al. Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement. Bulletin of Experimental Biology and Medicine. 2023 May;175(1):78-85. doi: 10.1007/s10517-023-05815-0

Author

Kechin, A. A. ; Koryukov, M. A. ; Smertina, M. A. et al. / Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement. In: Bulletin of Experimental Biology and Medicine. 2023 ; Vol. 175, No. 1. pp. 78-85.

BibTeX

@article{ea934900cbcc48f2b7e3d021a228d41d,
title = "Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement",
abstract = "For tumors with chimeric NTRK genes, entrectinib and larotrectinib can be prescribed regardless of tumor localization. We compared changes in the transcriptional activity of genes in brain tumors (BT) and thyroid cancer (TC) with rearrangement (NTRK+) and without rearrangement (NTRK-) of the NTRK genes using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We revealed an increase in the transcription of the JUN gene in NTRK+ samples in comparison with NTRK- samples: by 1.6 times for BT (p=0.239) and by 2.5 times for TC (p=0.003). The transcription of eight HOX genes in NTRK+ BT samples was also increased (by 85-725 times, p",
keywords = "NTRK, brain tumor, glioma, neurotrophin receptors, thyroid cancer, MicroRNAs/genetics, Neoplasms/pathology, Humans, Transcriptome, Brain Neoplasms/genetics, Thyroid Neoplasms/genetics, Brain/pathology, Gene Rearrangement",
author = "Kechin, {A. A.} and Koryukov, {M. A.} and Smertina, {M. A.} and Borobova, {V. S.} and Oscorbin, {I. P.} and Ivanov, {A. A.} and Bakharev, {S. Yu} and Boyarskikh, {U. A.} and Kushlinskii, {N. E.} and Filipenko, {M. L.}",
note = "The work was supported by the Russian Science Foundation (grant No. 20-15-00418; Investigation of the Molecular Mechanisms of the Development of Resistance of Tumor Cells with Chimeric NTRK Proteins to Tyrosine Kinase Inhibitors In Vitro). Публикация для корректировки.",
year = "2023",
month = may,
doi = "10.1007/s10517-023-05815-0",
language = "English",
volume = "175",
pages = "78--85",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - Differences in Transcriptomic Profiles of Brain and Thyroid Tumors with NTRK Gene Rearrangement

AU - Kechin, A. A.

AU - Koryukov, M. A.

AU - Smertina, M. A.

AU - Borobova, V. S.

AU - Oscorbin, I. P.

AU - Ivanov, A. A.

AU - Bakharev, S. Yu

AU - Boyarskikh, U. A.

AU - Kushlinskii, N. E.

AU - Filipenko, M. L.

N1 - The work was supported by the Russian Science Foundation (grant No. 20-15-00418; Investigation of the Molecular Mechanisms of the Development of Resistance of Tumor Cells with Chimeric NTRK Proteins to Tyrosine Kinase Inhibitors In Vitro). Публикация для корректировки.

PY - 2023/5

Y1 - 2023/5

N2 - For tumors with chimeric NTRK genes, entrectinib and larotrectinib can be prescribed regardless of tumor localization. We compared changes in the transcriptional activity of genes in brain tumors (BT) and thyroid cancer (TC) with rearrangement (NTRK+) and without rearrangement (NTRK-) of the NTRK genes using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We revealed an increase in the transcription of the JUN gene in NTRK+ samples in comparison with NTRK- samples: by 1.6 times for BT (p=0.239) and by 2.5 times for TC (p=0.003). The transcription of eight HOX genes in NTRK+ BT samples was also increased (by 85-725 times, p

AB - For tumors with chimeric NTRK genes, entrectinib and larotrectinib can be prescribed regardless of tumor localization. We compared changes in the transcriptional activity of genes in brain tumors (BT) and thyroid cancer (TC) with rearrangement (NTRK+) and without rearrangement (NTRK-) of the NTRK genes using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We revealed an increase in the transcription of the JUN gene in NTRK+ samples in comparison with NTRK- samples: by 1.6 times for BT (p=0.239) and by 2.5 times for TC (p=0.003). The transcription of eight HOX genes in NTRK+ BT samples was also increased (by 85-725 times, p

KW - NTRK

KW - brain tumor

KW - glioma

KW - neurotrophin receptors

KW - thyroid cancer

KW - MicroRNAs/genetics

KW - Neoplasms/pathology

KW - Humans

KW - Transcriptome

KW - Brain Neoplasms/genetics

KW - Thyroid Neoplasms/genetics

KW - Brain/pathology

KW - Gene Rearrangement

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85162273531&origin=inward&txGid=79f792e504cc875644ea7c9dc1bab756

UR - https://www.mendeley.com/catalogue/cbb2731f-0aac-31ea-b1d4-f2693b7b5a24/

U2 - 10.1007/s10517-023-05815-0

DO - 10.1007/s10517-023-05815-0

M3 - Article

C2 - 37335445

VL - 175

SP - 78

EP - 85

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 59627433