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Design and synthesis of new acridone-based nitric oxide fluorescent probe. / Panfilov, Mikhail; Chernova, Darya; Khalfina, Irina et al.

In: Molecules, Vol. 26, No. 14, 4340, 02.07.2021.

Research output: Contribution to journal › Article › peer-review

Harvard

Panfilov, M, Chernova, D, Khalfina, I, Moskalensky, A & Vorob’ev, A 2021, 'Design and synthesis of new acridone-based nitric oxide fluorescent probe', Molecules, vol. 26, no. 14, 4340. https://doi.org/10.3390/molecules26144340

APA

Panfilov, M., Chernova, D., Khalfina, I., Moskalensky, A., & Vorob’ev, A. (2021). Design and synthesis of new acridone-based nitric oxide fluorescent probe. Molecules, 26(14), [4340]. https://doi.org/10.3390/molecules26144340

Vancouver

Panfilov M, Chernova D, Khalfina I, Moskalensky A, Vorob’ev A. Design and synthesis of new acridone-based nitric oxide fluorescent probe. Molecules. 2021 Jul 2;26(14):4340. doi: 10.3390/molecules26144340

Author

Panfilov, Mikhail ; Chernova, Darya ; Khalfina, Irina et al. / Design and synthesis of new acridone-based nitric oxide fluorescent probe. In: Molecules. 2021 ; Vol. 26, No. 14.

BibTeX

@article{73484efaf0a54e16aae7760aed686562,
title = "Design and synthesis of new acridone-based nitric oxide fluorescent probe",
abstract = "Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.",
keywords = "9(10H)acridone, Fluorescent probes, Nitric oxide probes",
author = "Mikhail Panfilov and Darya Chernova and Irina Khalfina and Alexander Moskalensky and Aleksey Vorob{\textquoteright}ev",
note = "Funding Information: Funding: The synthesis of chemical compounds was supported by the Russian Ministry of Education (project no. 0238-2019-0005). The authors thank the Russian Science Foundation (project no. 18-15-00049) for supporting spectral and biological studies with Jurkat cells. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jul,
day = "2",
doi = "10.3390/molecules26144340",
language = "English",
volume = "26",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "14",

}

RIS

TY - JOUR

T1 - Design and synthesis of new acridone-based nitric oxide fluorescent probe

AU - Panfilov, Mikhail

AU - Chernova, Darya

AU - Khalfina, Irina

AU - Moskalensky, Alexander

AU - Vorob’ev, Aleksey

N1 - Funding Information: Funding: The synthesis of chemical compounds was supported by the Russian Ministry of Education (project no. 0238-2019-0005). The authors thank the Russian Science Foundation (project no. 18-15-00049) for supporting spectral and biological studies with Jurkat cells. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/7/2

Y1 - 2021/7/2

N2 - Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.

AB - Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.

KW - 9(10H)acridone

KW - Fluorescent probes

KW - Nitric oxide probes

UR - http://www.scopus.com/inward/record.url?scp=85111299095&partnerID=8YFLogxK

U2 - 10.3390/molecules26144340

DO - 10.3390/molecules26144340

M3 - Article

C2 - 34299615

AN - SCOPUS:85111299095

VL - 26

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 14

M1 - 4340

ER -

ID: 29128304