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Dendriplex-Impregnated Hydrogels With Programmed Release Rate. / Apartsin, Evgeny; Venyaminova, Alya; Majoral, Jean Pierre et al.

In: Frontiers in Chemistry, Vol. 9, 780608, 05.01.2022.

Research output: Contribution to journal › Article › peer-review

Harvard

Apartsin, E, Venyaminova, A, Majoral, JP & Caminade, AM 2022, 'Dendriplex-Impregnated Hydrogels With Programmed Release Rate', Frontiers in Chemistry, vol. 9, 780608. https://doi.org/10.3389/fchem.2021.780608

APA

Apartsin, E., Venyaminova, A., Majoral, J. P., & Caminade, A. M. (2022). Dendriplex-Impregnated Hydrogels With Programmed Release Rate. Frontiers in Chemistry, 9, [780608]. https://doi.org/10.3389/fchem.2021.780608

Vancouver

Apartsin E, Venyaminova A, Majoral JP, Caminade AM. Dendriplex-Impregnated Hydrogels With Programmed Release Rate. Frontiers in Chemistry. 2022 Jan 5;9:780608. doi: 10.3389/fchem.2021.780608

Author

Apartsin, Evgeny ; Venyaminova, Alya ; Majoral, Jean Pierre et al. / Dendriplex-Impregnated Hydrogels With Programmed Release Rate. In: Frontiers in Chemistry. 2022 ; Vol. 9.

BibTeX

@article{9ace9ab1664149169de5d106e4062534,
title = "Dendriplex-Impregnated Hydrogels With Programmed Release Rate",
abstract = "Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.",
keywords = "controlled release, dendrimers, hydrogel, oligonucleotides, polyelectrolyte complexes",
author = "Evgeny Apartsin and Alya Venyaminova and Majoral, {Jean Pierre} and Caminade, {Anne Marie}",
note = "Funding Information: The project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 844217. This article is based on work from COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside” supported by the COST (European Cooperation in Science and Technology). The financial support from the CNRS is also appreciated. Publisher Copyright: Copyright {\textcopyright} 2022 Apartsin, Venyaminova, Majoral and Caminade.",
year = "2022",
month = jan,
day = "5",
doi = "10.3389/fchem.2021.780608",
language = "English",
volume = "9",
journal = "Frontiers in Chemistry",
issn = "2296-2646",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Dendriplex-Impregnated Hydrogels With Programmed Release Rate

AU - Apartsin, Evgeny

AU - Venyaminova, Alya

AU - Majoral, Jean Pierre

AU - Caminade, Anne Marie

N1 - Funding Information: The project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 844217. This article is based on work from COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside” supported by the COST (European Cooperation in Science and Technology). The financial support from the CNRS is also appreciated. Publisher Copyright: Copyright © 2022 Apartsin, Venyaminova, Majoral and Caminade.

PY - 2022/1/5

Y1 - 2022/1/5

N2 - Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.

AB - Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.

KW - controlled release

KW - dendrimers

KW - hydrogel

KW - oligonucleotides

KW - polyelectrolyte complexes

UR - http://www.scopus.com/inward/record.url?scp=85123100535&partnerID=8YFLogxK

U2 - 10.3389/fchem.2021.780608

DO - 10.3389/fchem.2021.780608

M3 - Article

C2 - 35071182

AN - SCOPUS:85123100535

VL - 9

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

SN - 2296-2646

M1 - 780608

ER -

ID: 35322534