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Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells. / Kovaleva, Kseniya; Oleshko, Olga; Mamontova, Evgeniya et al.

In: Journal of Natural Products, Vol. 82, No. 9, 27.09.2019, p. 2443-2450.

Research output: Contribution to journal › Article › peer-review

Harvard

Kovaleva, K, Oleshko, O, Mamontova, E, Yarovaya, O, Zakharova, O, Zakharenko, A, Kononova, A, Dyrkheeva, N, Cheresiz, S, Pokrovsky, A, Lavrik, O & Salakhutdinov, N 2019, 'Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells', Journal of Natural Products, vol. 82, no. 9, pp. 2443-2450. https://doi.org/10.1021/acs.jnatprod.8b01095

APA

Kovaleva, K., Oleshko, O., Mamontova, E., Yarovaya, O., Zakharova, O., Zakharenko, A., Kononova, A., Dyrkheeva, N., Cheresiz, S., Pokrovsky, A., Lavrik, O., & Salakhutdinov, N. (2019). Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells. Journal of Natural Products, 82(9), 2443-2450. https://doi.org/10.1021/acs.jnatprod.8b01095

Vancouver

Kovaleva K, Oleshko O, Mamontova E, Yarovaya O, Zakharova O, Zakharenko A et al. Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells. Journal of Natural Products. 2019 Sept 27;82(9):2443-2450. doi: 10.1021/acs.jnatprod.8b01095

Author

Kovaleva, Kseniya ; Oleshko, Olga ; Mamontova, Evgeniya et al. / Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells. In: Journal of Natural Products. 2019 ; Vol. 82, No. 9. pp. 2443-2450.

BibTeX

@article{722f9aa3b20e44fe85a32698e80c552a,
title = "Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells",
abstract = "A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors was found among resin acid derivatives. Several novel ureas and thioureas derived from dehydroabietylamine were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC50 values in the range of 0.1 to 3.7 μM and demonstrated low cytotoxicity against the human tumor cell lines U-937, U-87MG, MDA-MB, SK-Mel8, A-549, MCF7, T98G, and SNB19. Several compounds showed enhancement of the cytotoxic activity of the alkylating agent temozolomide, which is used as a first line therapy against glioblastoma (GBM), in the GBM cell lines U-87MG and SNB19.",
keywords = "TOPOISOMERASE-I, TDP1, DERIVATIVES, KETONES, ENZYME, DAMAGE",
author = "Kseniya Kovaleva and Olga Oleshko and Evgeniya Mamontova and Olga Yarovaya and Olga Zakharova and Alexandra Zakharenko and Alena Kononova and Nadezhda Dyrkheeva and Sergey Cheresiz and Andrey Pokrovsky and Olga Lavrik and Nariman Salakhutdinov",
note = "Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society and American Society of Pharmacognosy.",
year = "2019",
month = sep,
day = "27",
doi = "10.1021/acs.jnatprod.8b01095",
language = "English",
volume = "82",
pages = "2443--2450",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "9",

}

RIS

TY - JOUR

T1 - Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells

AU - Kovaleva, Kseniya

AU - Oleshko, Olga

AU - Mamontova, Evgeniya

AU - Yarovaya, Olga

AU - Zakharova, Olga

AU - Zakharenko, Alexandra

AU - Kononova, Alena

AU - Dyrkheeva, Nadezhda

AU - Cheresiz, Sergey

AU - Pokrovsky, Andrey

AU - Lavrik, Olga

AU - Salakhutdinov, Nariman

N1 - Publisher Copyright: Copyright © 2019 American Chemical Society and American Society of Pharmacognosy.

PY - 2019/9/27

Y1 - 2019/9/27

N2 - A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors was found among resin acid derivatives. Several novel ureas and thioureas derived from dehydroabietylamine were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC50 values in the range of 0.1 to 3.7 μM and demonstrated low cytotoxicity against the human tumor cell lines U-937, U-87MG, MDA-MB, SK-Mel8, A-549, MCF7, T98G, and SNB19. Several compounds showed enhancement of the cytotoxic activity of the alkylating agent temozolomide, which is used as a first line therapy against glioblastoma (GBM), in the GBM cell lines U-87MG and SNB19.

AB - A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors was found among resin acid derivatives. Several novel ureas and thioureas derived from dehydroabietylamine were synthesized and tested for TDP1 inhibition. The synthesized compounds showed IC50 values in the range of 0.1 to 3.7 μM and demonstrated low cytotoxicity against the human tumor cell lines U-937, U-87MG, MDA-MB, SK-Mel8, A-549, MCF7, T98G, and SNB19. Several compounds showed enhancement of the cytotoxic activity of the alkylating agent temozolomide, which is used as a first line therapy against glioblastoma (GBM), in the GBM cell lines U-87MG and SNB19.

KW - TOPOISOMERASE-I

KW - TDP1

KW - DERIVATIVES

KW - KETONES

KW - ENZYME

KW - DAMAGE

UR - http://www.scopus.com/inward/record.url?scp=85071862995&partnerID=8YFLogxK

U2 - 10.1021/acs.jnatprod.8b01095

DO - 10.1021/acs.jnatprod.8b01095

M3 - Article

C2 - 31430155

AN - SCOPUS:85071862995

VL - 82

SP - 2443

EP - 2450

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 9

ER -

ID: 21465508