Default Mode Network Connections Supporting Intra- Individual Variability in Typically Developing Primary School Children: An EEG Study

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Default Mode Network Connections Supporting Intra- Individual Variability in Typically Developing Primary School Children: An EEG Study. / Privodnova, Evgeniya Yu; Slobodskaya, Helena R.; Bocharov, Andrey V. et al.

In: Neuropsychology, Vol. 34, No. 7, 10.2020, p. 811-823.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{a15b3a5b6bb244b0ae0c3f173b70b254,

title = "Default Mode Network Connections Supporting Intra- Individual Variability in Typically Developing Primary School Children: An EEG Study",

abstract = "Objective: Intraindividual variability in response time (RT) provides information about attention abilities beyond accuracy and mean RT. It could be an endophenotype for a wide range of clinical disorders and a general marker of neurological health or maladaptation. The default mode network (DMN) and the central executive and the salience networks (CEN + SN) support response stability in adults. The aim of this study was to explore the associations of resting-state connectivity of the DMN and the CEN + SN with lapses of attention in typically developing primary schoolchildren. Method: RT variability was measured by RT standard deviation in the self-paced Stroop-like Animal Size Test in 137 children aged 6-11 years. Electrophysiological signatures of the DMN and the CEN + SN were obtained using a seed-based oscillatory power envelope correlation in conjunction with beamformer spatial filtering. Results: Statistical nonparametric mapping showed that RT variability was positively associated with connectivity between the DMN and the posterior insula and the right temporal cortex (PFWE-corr < .006), suggesting that a greater focus of self-reflective internal attention may be associated with obstructed transition to an active processing mode. RT variability was negatively associated with connectivity between the DMN and the anterior cingulate and the anterior insula (PFWE-corr = .001) overlapping with the SN, which handles top-down cognitive regulation. These associations were specifically found for the anterior DMN seed in the medial prefrontal cortex, which is involved in emotion and motivational circuits. Conclusions: Default network connectivity supporting RT variability may be involved in the development of internalizing and externalizing problems in childhood.",

keywords = "Children, Intra-individual variability, Response time variability, Resting-state networks, EEG, ATTENTION, HUMAN BRAIN, RESTING STATE NETWORKS, EEG, FUNCTIONAL CONNECTIVITY, CHILDHOOD, REACTION-TIME VARIABILITY, MEG, intra-individual variability, EXECUTIVE FUNCTION, children, CINGULATE CORTEX, resting-state networks, DEVELOPMENTAL-CHANGES, response time variability",

author = "Privodnova, {Evgeniya Yu} and Slobodskaya, {Helena R.} and Bocharov, {Andrey V.} and Saprigyn, {Alexander E.} and Knyazev, {Gennady G.}",

year = "2020",

month = oct,

doi = "10.1037/neu0000699",

language = "English",

volume = "34",

pages = "811--823",

journal = "Neuropsychology",

issn = "0894-4105",

publisher = "AMER PSYCHOLOGICAL ASSOC",

number = "7",

}

RIS

TY - JOUR

T1 - Default Mode Network Connections Supporting Intra- Individual Variability in Typically Developing Primary School Children: An EEG Study

AU - Privodnova, Evgeniya Yu

AU - Slobodskaya, Helena R.

AU - Bocharov, Andrey V.

AU - Saprigyn, Alexander E.

AU - Knyazev, Gennady G.

PY - 2020/10

Y1 - 2020/10

N2 - Objective: Intraindividual variability in response time (RT) provides information about attention abilities beyond accuracy and mean RT. It could be an endophenotype for a wide range of clinical disorders and a general marker of neurological health or maladaptation. The default mode network (DMN) and the central executive and the salience networks (CEN + SN) support response stability in adults. The aim of this study was to explore the associations of resting-state connectivity of the DMN and the CEN + SN with lapses of attention in typically developing primary schoolchildren. Method: RT variability was measured by RT standard deviation in the self-paced Stroop-like Animal Size Test in 137 children aged 6-11 years. Electrophysiological signatures of the DMN and the CEN + SN were obtained using a seed-based oscillatory power envelope correlation in conjunction with beamformer spatial filtering. Results: Statistical nonparametric mapping showed that RT variability was positively associated with connectivity between the DMN and the posterior insula and the right temporal cortex (PFWE-corr < .006), suggesting that a greater focus of self-reflective internal attention may be associated with obstructed transition to an active processing mode. RT variability was negatively associated with connectivity between the DMN and the anterior cingulate and the anterior insula (PFWE-corr = .001) overlapping with the SN, which handles top-down cognitive regulation. These associations were specifically found for the anterior DMN seed in the medial prefrontal cortex, which is involved in emotion and motivational circuits. Conclusions: Default network connectivity supporting RT variability may be involved in the development of internalizing and externalizing problems in childhood.

AB - Objective: Intraindividual variability in response time (RT) provides information about attention abilities beyond accuracy and mean RT. It could be an endophenotype for a wide range of clinical disorders and a general marker of neurological health or maladaptation. The default mode network (DMN) and the central executive and the salience networks (CEN + SN) support response stability in adults. The aim of this study was to explore the associations of resting-state connectivity of the DMN and the CEN + SN with lapses of attention in typically developing primary schoolchildren. Method: RT variability was measured by RT standard deviation in the self-paced Stroop-like Animal Size Test in 137 children aged 6-11 years. Electrophysiological signatures of the DMN and the CEN + SN were obtained using a seed-based oscillatory power envelope correlation in conjunction with beamformer spatial filtering. Results: Statistical nonparametric mapping showed that RT variability was positively associated with connectivity between the DMN and the posterior insula and the right temporal cortex (PFWE-corr < .006), suggesting that a greater focus of self-reflective internal attention may be associated with obstructed transition to an active processing mode. RT variability was negatively associated with connectivity between the DMN and the anterior cingulate and the anterior insula (PFWE-corr = .001) overlapping with the SN, which handles top-down cognitive regulation. These associations were specifically found for the anterior DMN seed in the medial prefrontal cortex, which is involved in emotion and motivational circuits. Conclusions: Default network connectivity supporting RT variability may be involved in the development of internalizing and externalizing problems in childhood.

KW - Children

KW - Intra-individual variability

KW - Response time variability

KW - Resting-state networks, EEG

KW - ATTENTION

KW - HUMAN BRAIN

KW - RESTING STATE NETWORKS

KW - EEG

KW - FUNCTIONAL CONNECTIVITY

KW - CHILDHOOD

KW - REACTION-TIME VARIABILITY

KW - MEG

KW - intra-individual variability

KW - EXECUTIVE FUNCTION

KW - children

KW - CINGULATE CORTEX

KW - resting-state networks

KW - DEVELOPMENTAL-CHANGES

KW - response time variability

UR - http://www.scopus.com/inward/record.url?scp=85091023996&partnerID=8YFLogxK

U2 - 10.1037/neu0000699

DO - 10.1037/neu0000699

M3 - Article

C2 - 32924516

AN - SCOPUS:85091023996

VL - 34

SP - 811

EP - 823

JO - Neuropsychology

JF - Neuropsychology

SN - 0894-4105

IS - 7

ER -

ID: 26152474