TY - CHAP

T1 - Dedicated Solutions: DC Tandem Accelerator

AU - Taskaev, Sergey Yu

AU - Dunaevsky, Alex

N1 - Taskaev, S.Y., Dunaevsky, A. (2025). Dedicated Solutions: DC Tandem Accelerator. In: Sauerwein, W.A.G., Wittig, A., Moss, R.L., Nakagawa, Y., Ono, K. (eds) Neutron Capture Therapy. Springer, Cham. https://doi.org/10.1007/978-3-031-82591-0_10 The study was supported by the Budker Institute of Nuclear Physics, TAE Life Sciences, LLC., the International Science and Technology Center, the Ministry of Science and Education of the Russian Federation, the Russian Science Foundation (projects 14-32-00006 and 19-72-30005), and a number of organizations and foundations.

PY - 2025/5/31

Y1 - 2025/5/31

N2 - Among a wide variety of accelerators applicable for neutron sources suitable for clinical applications for BNCT, DC accelerators are among the most suitable and cost-effective. Several teams around the world pursue the development of accelerator-based BNCT (AB-BNCT) systems based on DC accelerators of protons in combination with lithium targets for the production of beams of epithermal neutrons. In this chapter, a tandem accelerator is described, which is a specific type of DC accelerator. The design of a Vacuum Insulated Tandem Accelerator (VITA) was first proposed several decades ago by a group of scientists at Budker Institute of Nuclear Physics (BINP). This chapter provides an overview of the design, specific features, improvements, results of experimental studies, and the achieved parameters of the proton beam. The VITA proton beam is directed towards a lithium (Li) target to generate neutrons with a total flux sufficient for clinical applications. Formation of the directed beam of epithermal neutrons occurs in a specially designed beam-shaping assembly that surrounds the Li target. In this chapter, special attention is paid to the concept of the Li target, its principle of operation, and the approaches to achieve a long lifetime of the target. Concepts of design of the beam shaping assembly proposed by the BINP group are also discussed in this chapter, along with ideas on dosimetry, boron imaging, and results from a preliminary biological research program at BINP. Implementation of a commercial Neutron Beam System (NBS) suitable for hospital-based clinical research and as a potential first-line cancer treatment modality is being developed by TAE Life Sciences. Based on the VITA concept, the TAE Life Sciences’ NBS offers a largely improved design of the tandem accelerator and the Li target assembly. The NBS configuration supports a single or multi-treatment room design. TAE Life Sciences plans to install its first commercial NBS at the new BNCT Center at Xiamen Humanity Hospital in Xiamen, P.R. China, in 2020. The NBS will serve as the neutron source that will be integrated with other components provided by Neuboron Medtech Ltd. (Nanjing, P.R. China), who will manage the operation of the integrated system within the BNCT Center.

AB - Among a wide variety of accelerators applicable for neutron sources suitable for clinical applications for BNCT, DC accelerators are among the most suitable and cost-effective. Several teams around the world pursue the development of accelerator-based BNCT (AB-BNCT) systems based on DC accelerators of protons in combination with lithium targets for the production of beams of epithermal neutrons. In this chapter, a tandem accelerator is described, which is a specific type of DC accelerator. The design of a Vacuum Insulated Tandem Accelerator (VITA) was first proposed several decades ago by a group of scientists at Budker Institute of Nuclear Physics (BINP). This chapter provides an overview of the design, specific features, improvements, results of experimental studies, and the achieved parameters of the proton beam. The VITA proton beam is directed towards a lithium (Li) target to generate neutrons with a total flux sufficient for clinical applications. Formation of the directed beam of epithermal neutrons occurs in a specially designed beam-shaping assembly that surrounds the Li target. In this chapter, special attention is paid to the concept of the Li target, its principle of operation, and the approaches to achieve a long lifetime of the target. Concepts of design of the beam shaping assembly proposed by the BINP group are also discussed in this chapter, along with ideas on dosimetry, boron imaging, and results from a preliminary biological research program at BINP. Implementation of a commercial Neutron Beam System (NBS) suitable for hospital-based clinical research and as a potential first-line cancer treatment modality is being developed by TAE Life Sciences. Based on the VITA concept, the TAE Life Sciences’ NBS offers a largely improved design of the tandem accelerator and the Li target assembly. The NBS configuration supports a single or multi-treatment room design. TAE Life Sciences plans to install its first commercial NBS at the new BNCT Center at Xiamen Humanity Hospital in Xiamen, P.R. China, in 2020. The NBS will serve as the neutron source that will be integrated with other components provided by Neuboron Medtech Ltd. (Nanjing, P.R. China), who will manage the operation of the integrated system within the BNCT Center.

KW - Beam shaping assembly

KW - Lithium target

KW - Tandem accelerator

UR - https://www.scopus.com/pages/publications/105022222234

UR - https://www.mendeley.com/catalogue/570289cd-2b07-3250-97b9-4bea23c143b3/

U2 - 10.1007/978-3-031-82591-0_10

DO - 10.1007/978-3-031-82591-0_10

M3 - Chapter

SN - 978-3-031-82590-3

SP - 115

EP - 125

BT - Neutron Capture Therapy: Principles and Applications

PB - Springer

ER -