Decoding the role of zebrafish neuroglia in CNS disease modeling

Standard

Decoding the role of zebrafish neuroglia in CNS disease modeling. / Zabegalov, Konstantin N.; Wang, Dongmei; Yang, Long En et al.

In: Brain Research Bulletin, Vol. 166, 01.2021, p. 44-53.

Research output: Contribution to journal › Review article › peer-review

Harvard

Zabegalov, KN, Wang, D, Yang, LE, Wang, J, Hu, G, Serikuly, N, Alpyshov, ET, Khatsko, SL, Zhdanov, A, Demin, KA, Galstyan, DS, Volgin, AD, de Abreu, MS, Strekalova, T, Song, C, Amstislavskaya, TG, Sysoev, Y, Musienko, PE & Kalueff, AV 2021, 'Decoding the role of zebrafish neuroglia in CNS disease modeling', Brain Research Bulletin, vol. 166, pp. 44-53. https://doi.org/10.1016/j.brainresbull.2020.09.020

APA

Zabegalov, K. N., Wang, D., Yang, L. E., Wang, J., Hu, G., Serikuly, N., Alpyshov, E. T., Khatsko, S. L., Zhdanov, A., Demin, K. A., Galstyan, D. S., Volgin, A. D., de Abreu, M. S., Strekalova, T., Song, C., Amstislavskaya, T. G., Sysoev, Y., Musienko, P. E., & Kalueff, A. V. (2021). Decoding the role of zebrafish neuroglia in CNS disease modeling. Brain Research Bulletin, 166, 44-53. https://doi.org/10.1016/j.brainresbull.2020.09.020

Vancouver

Zabegalov KN, Wang D, Yang LE, Wang J, Hu G, Serikuly N et al. Decoding the role of zebrafish neuroglia in CNS disease modeling. Brain Research Bulletin. 2021 Jan;166:44-53. Epub 2020 Oct 4. doi: 10.1016/j.brainresbull.2020.09.020

Author

Zabegalov, Konstantin N. ; Wang, Dongmei ; Yang, Long En et al. / Decoding the role of zebrafish neuroglia in CNS disease modeling. In: Brain Research Bulletin. 2021 ; Vol. 166. pp. 44-53.

BibTeX

@article{ff29130b8d544ca08be9fdfa79442067,

title = "Decoding the role of zebrafish neuroglia in CNS disease modeling",

abstract = "Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.",

keywords = "CNS disorders, Macroglia, Microglia, Neuroglia, Rodents, Zebrafish",

author = "Zabegalov, {Konstantin N.} and Dongmei Wang and Yang, {Long En} and Jingtao Wang and Guojun Hu and Nazar Serikuly and Alpyshov, {Erik T.} and Khatsko, {Sergey L.} and Aleksander Zhdanov and Demin, {Konstantin A.} and Galstyan, {David S.} and Volgin, {Andrey D.} and {de Abreu}, {Murilo S.} and Tatyana Strekalova and Cai Song and Amstislavskaya, {Tamara G.} and Yury Sysoev and Musienko, {Pavel E.} and Kalueff, {Allan V.}",

year = "2021",

month = jan,

doi = "10.1016/j.brainresbull.2020.09.020",

language = "English",

volume = "166",

pages = "44--53",

journal = "Brain Research Bulletin",

issn = "0361-9230",

publisher = "Elsevier Science Inc.",

}

RIS

TY - JOUR

T1 - Decoding the role of zebrafish neuroglia in CNS disease modeling

AU - Zabegalov, Konstantin N.

AU - Wang, Dongmei

AU - Yang, Long En

AU - Wang, Jingtao

AU - Hu, Guojun

AU - Serikuly, Nazar

AU - Alpyshov, Erik T.

AU - Khatsko, Sergey L.

AU - Zhdanov, Aleksander

AU - Demin, Konstantin A.

AU - Galstyan, David S.

AU - Volgin, Andrey D.

AU - de Abreu, Murilo S.

AU - Strekalova, Tatyana

AU - Song, Cai

AU - Amstislavskaya, Tamara G.

AU - Sysoev, Yury

AU - Musienko, Pavel E.

AU - Kalueff, Allan V.

PY - 2021/1

Y1 - 2021/1

N2 - Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.

AB - Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.

KW - CNS disorders

KW - Macroglia

KW - Microglia

KW - Neuroglia

KW - Rodents

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85096462985&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/299f352f-a445-3cee-9d9b-17159c6f0960/

U2 - 10.1016/j.brainresbull.2020.09.020

DO - 10.1016/j.brainresbull.2020.09.020

M3 - Review article

C2 - 33027679

AN - SCOPUS:85096462985

VL - 166

SP - 44

EP - 53

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

ER -

ID: 26134420