Data of correlation analysis between the density of H3K4me3 in promoters of genes and gene expression

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Data of correlation analysis between the density of H3K4me3 in promoters of genes and gene expression : Data from RNA-seq and ChIP-seq analyses of the murine prefrontal cortex. / Reshetnikov, V. V.; Kisaretova, P. E.; Ershov, N. I. et al.

In: Data in Brief, Vol. 33, 106365, 12.2020.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{735dfb3d1f37438e8b62651a21c754ac,

title = "Data of correlation analysis between the density of H3K4me3 in promoters of genes and gene expression: Data from RNA-seq and ChIP-seq analyses of the murine prefrontal cortex",

abstract = "H3K4me3 is typically found in the promoter region of genes and is a mark associated with an open chromatin state and active gene transcription. Nonetheless, the role of H3K4me3 in the regulation of transcription is still debated. To improve the understanding of the connection between H3K4me3 density in promoters and gene expression, we assessed the correlation between these two parameters. We utilized genome-wide high-throughput RNA sequencing (RNA-seq) data and H3K4me3-based chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq), carried out on the same samples of the prefrontal cortex from 10 male C57Bl6 mice with different stress experience [Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: an impact of early-life stress, 1]. In addition, we assessed the correlation between H3K4me3 density and gene expression in datasets of cell-specific genes. Altogether, the results are useful for the elucidation of H3K4me3 involvement in the regulation of transcription in the murine prefrontal cortex.",

keywords = "Cell specificity, ChIP-seq, Epigenetics, H3K4me3, Prefrontal cortex, RNA-seq",

author = "Reshetnikov, {V. V.} and Kisaretova, {P. E.} and Ershov, {N. I.} and Merkulova, {T. I.} and Bondar, {N. P.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = dec,

doi = "10.1016/j.dib.2020.106365",

language = "English",

volume = "33",

journal = "Data in Brief",

issn = "2352-3409",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Data of correlation analysis between the density of H3K4me3 in promoters of genes and gene expression

T2 - Data from RNA-seq and ChIP-seq analyses of the murine prefrontal cortex

AU - Reshetnikov, V. V.

AU - Kisaretova, P. E.

AU - Ershov, N. I.

AU - Merkulova, T. I.

AU - Bondar, N. P.

PY - 2020/12

Y1 - 2020/12

N2 - H3K4me3 is typically found in the promoter region of genes and is a mark associated with an open chromatin state and active gene transcription. Nonetheless, the role of H3K4me3 in the regulation of transcription is still debated. To improve the understanding of the connection between H3K4me3 density in promoters and gene expression, we assessed the correlation between these two parameters. We utilized genome-wide high-throughput RNA sequencing (RNA-seq) data and H3K4me3-based chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq), carried out on the same samples of the prefrontal cortex from 10 male C57Bl6 mice with different stress experience [Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: an impact of early-life stress, 1]. In addition, we assessed the correlation between H3K4me3 density and gene expression in datasets of cell-specific genes. Altogether, the results are useful for the elucidation of H3K4me3 involvement in the regulation of transcription in the murine prefrontal cortex.

AB - H3K4me3 is typically found in the promoter region of genes and is a mark associated with an open chromatin state and active gene transcription. Nonetheless, the role of H3K4me3 in the regulation of transcription is still debated. To improve the understanding of the connection between H3K4me3 density in promoters and gene expression, we assessed the correlation between these two parameters. We utilized genome-wide high-throughput RNA sequencing (RNA-seq) data and H3K4me3-based chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq), carried out on the same samples of the prefrontal cortex from 10 male C57Bl6 mice with different stress experience [Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: an impact of early-life stress, 1]. In addition, we assessed the correlation between H3K4me3 density and gene expression in datasets of cell-specific genes. Altogether, the results are useful for the elucidation of H3K4me3 involvement in the regulation of transcription in the murine prefrontal cortex.

KW - Cell specificity

KW - ChIP-seq

KW - Epigenetics

KW - H3K4me3

KW - Prefrontal cortex

KW - RNA-seq

UR - http://www.scopus.com/inward/record.url?scp=85092712024&partnerID=8YFLogxK

U2 - 10.1016/j.dib.2020.106365

DO - 10.1016/j.dib.2020.106365

M3 - Article

C2 - 33102649

AN - SCOPUS:85092712024

VL - 33

JO - Data in Brief

JF - Data in Brief

SN - 2352-3409

M1 - 106365

ER -

ID: 25676731

Data of correlation analysis between the density of H3K4me3 in promoters of genes and gene expression: Data from RNA-seq and ChIP-seq analyses of the murine prefrontal cortex

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