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Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins. / Kuzmich, Alexandra S.; Khomenko, Tatyana M.; Fedorov, Sergey N. et al.

In: Medicinal Chemistry Research, Vol. 26, No. 2, 01.02.2017, p. 397-404.

Research output: Contribution to journal › Article › peer-review

Harvard

Kuzmich, AS, Khomenko, TM, Fedorov, SN, Makarieva, TN, Shubina, LK, Komarova, NI, Korchagina, DV, Rybalova, TV, Volcho, KP & Salakhutdinov, NF 2017, 'Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins', Medicinal Chemistry Research, vol. 26, no. 2, pp. 397-404. https://doi.org/10.1007/s00044-016-1759-8

APA

Kuzmich, A. S., Khomenko, T. M., Fedorov, S. N., Makarieva, T. N., Shubina, L. K., Komarova, N. I., Korchagina, D. V., Rybalova, T. V., Volcho, K. P., & Salakhutdinov, N. F. (2017). Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins. Medicinal Chemistry Research, 26(2), 397-404. https://doi.org/10.1007/s00044-016-1759-8

Vancouver

Kuzmich AS, Khomenko TM, Fedorov SN, Makarieva TN, Shubina LK, Komarova NI et al. Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins. Medicinal Chemistry Research. 2017 Feb 1;26(2):397-404. doi: 10.1007/s00044-016-1759-8

Author

Kuzmich, Alexandra S. ; Khomenko, Tatyana M. ; Fedorov, Sergey N. et al. / Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins. In: Medicinal Chemistry Research. 2017 ; Vol. 26, No. 2. pp. 397-404.

BibTeX

@article{ddaf7a5617a14010a46c859ba795d003,
title = "Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins",
abstract = "The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.",
keywords = "Cancer preventive activity, Cytotoxicity, Oncology, Polysulfide compounds, Varacin",
author = "Kuzmich, {Alexandra S.} and Khomenko, {Tatyana M.} and Fedorov, {Sergey N.} and Makarieva, {Tatyana N.} and Shubina, {Larisa K.} and Komarova, {Nina I.} and Korchagina, {Dina V.} and Rybalova, {Tatyana V.} and Volcho, {Konstantin P.} and Salakhutdinov, {Nariman F.}",
year = "2017",
month = feb,
day = "1",
doi = "10.1007/s00044-016-1759-8",
language = "English",
volume = "26",
pages = "397--404",
journal = "Medicinal Chemistry Research",
issn = "1054-2523",
publisher = "Springer Nature",
number = "2",

}

RIS

TY - JOUR

T1 - Cytotoxic and cancer preventive activity of benzotrithioles and benzotrithiole oxides, synthetic analogues of varacins

AU - Kuzmich, Alexandra S.

AU - Khomenko, Tatyana M.

AU - Fedorov, Sergey N.

AU - Makarieva, Tatyana N.

AU - Shubina, Larisa K.

AU - Komarova, Nina I.

AU - Korchagina, Dina V.

AU - Rybalova, Tatyana V.

AU - Volcho, Konstantin P.

AU - Salakhutdinov, Nariman F.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.

AB - The cytotoxic and cancer preventive activities of synthetic analogs of natural varacins with polysulfide groups were studied. Presence of a sulfoxide group was found to have no significant effect on the cytotoxicity of these compounds. At the same time, this group is important for inhibition of colony formation of tumor cells treated with tumor promoter thus demonstrating cancer preventive activity. The most promising compound appears to be a synthetic varacin C analog, sulfoxide 10a, which exhibits the cancer preventive activity at dose into 100 times lower than its cytotoxic concentrations.

KW - Cancer preventive activity

KW - Cytotoxicity

KW - Oncology

KW - Polysulfide compounds

KW - Varacin

UR - http://www.scopus.com/inward/record.url?scp=85006094837&partnerID=8YFLogxK

U2 - 10.1007/s00044-016-1759-8

DO - 10.1007/s00044-016-1759-8

M3 - Article

AN - SCOPUS:85006094837

VL - 26

SP - 397

EP - 404

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

SN - 1054-2523

IS - 2

ER -

ID: 8969144