Cytological Characteristics of a Heterogeneous Population of Hepatocellular Carcinoma-29 Cells after Injection of Lithium Carbonate in the Experiment

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Cytological Characteristics of a Heterogeneous Population of Hepatocellular Carcinoma-29 Cells after Injection of Lithium Carbonate in the Experiment. / Taskaeva, Yu S.; Bgatova, N. P.

In: Bulletin of Experimental Biology and Medicine, Vol. 167, No. 6, 01.10.2019, p. 779-783.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{7bb32ab224ee43c28388df805faea2f5,

title = "Cytological Characteristics of a Heterogeneous Population of Hepatocellular Carcinoma-29 Cells after Injection of Lithium Carbonate in the Experiment",

abstract = "Five cytological types of hepatocellular carcinoma-29 (G-29) grown in the muscle tissue of the thigh of experimental animals were identified by transmission electron microscopy; 89% of these were poorly differentiated type I-III cells. Lithium in a concentration of 20 mM produced a damaging effect on poorly differentiated G-29 cells: the number of cells with zones of intracellular component destruction and volume density of these zones increased, while volume density of cisterns of endoplasmic reticulum decreased. These results suggest that lithium carbonate can cause destructive changes in the heterogeneous population of G-29 cells during in vivo tumor development.",

keywords = "electron microscopy, hepatocellular carcinoma, lithium carbonate, ultrastructural organization",

author = "Taskaeva, {Yu S.} and Bgatova, {N. P.}",

year = "2019",

month = oct,

day = "1",

doi = "10.1007/s10517-019-04621-x",

language = "English",

volume = "167",

pages = "779--783",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer New York",

number = "6",

}

RIS

TY - JOUR

T1 - Cytological Characteristics of a Heterogeneous Population of Hepatocellular Carcinoma-29 Cells after Injection of Lithium Carbonate in the Experiment

AU - Taskaeva, Yu S.

AU - Bgatova, N. P.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Five cytological types of hepatocellular carcinoma-29 (G-29) grown in the muscle tissue of the thigh of experimental animals were identified by transmission electron microscopy; 89% of these were poorly differentiated type I-III cells. Lithium in a concentration of 20 mM produced a damaging effect on poorly differentiated G-29 cells: the number of cells with zones of intracellular component destruction and volume density of these zones increased, while volume density of cisterns of endoplasmic reticulum decreased. These results suggest that lithium carbonate can cause destructive changes in the heterogeneous population of G-29 cells during in vivo tumor development.

AB - Five cytological types of hepatocellular carcinoma-29 (G-29) grown in the muscle tissue of the thigh of experimental animals were identified by transmission electron microscopy; 89% of these were poorly differentiated type I-III cells. Lithium in a concentration of 20 mM produced a damaging effect on poorly differentiated G-29 cells: the number of cells with zones of intracellular component destruction and volume density of these zones increased, while volume density of cisterns of endoplasmic reticulum decreased. These results suggest that lithium carbonate can cause destructive changes in the heterogeneous population of G-29 cells during in vivo tumor development.

KW - electron microscopy

KW - hepatocellular carcinoma

KW - lithium carbonate

KW - ultrastructural organization

UR - http://www.scopus.com/inward/record.url?scp=85074558413&partnerID=8YFLogxK

U2 - 10.1007/s10517-019-04621-x

DO - 10.1007/s10517-019-04621-x

M3 - Article

C2 - 31655987

AN - SCOPUS:85074558413

VL - 167

SP - 779

EP - 783

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 6

ER -

ID: 22364084