Could SLC26A7 Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?

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Could SLC26A7 Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? / Titov, Sergei E.; Kozorezova, Evgeniya S.; Lukyanov, Sergei A. et al.

In: Diagnostics, Vol. 14, No. 23, 2652, 12.2024.

Research output: Contribution to journal › Article › peer-review

Harvard

Titov, SE, Kozorezova, ES, Lukyanov, SA, Sergiyko, SV, Demenkov, PS, Veryaskina, YA, Vorobyev, SL, Sleptsov, IV, Chernikov, RA, Timofeeva, NI, Barashkova, SV, Lushnikova, EL, Uspenskaya, AA, Zolotoukho, AV, Romanova, OV & Zhimulev, IF 2024, 'Could SLC26A7 Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?', Diagnostics, vol. 14, no. 23, 2652. https://doi.org/10.3390/diagnostics14232652

APA

Titov, S. E., Kozorezova, E. S., Lukyanov, S. A., Sergiyko, S. V., Demenkov, P. S., Veryaskina, Y. A., Vorobyev, S. L., Sleptsov, I. V., Chernikov, R. A., Timofeeva, N. I., Barashkova, S. V., Lushnikova, E. L., Uspenskaya, A. A., Zolotoukho, A. V., Romanova, O. V., & Zhimulev, I. F. (2024). Could SLC26A7 Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? Diagnostics, 14(23), [2652]. https://doi.org/10.3390/diagnostics14232652

Vancouver

Titov SE, Kozorezova ES, Lukyanov SA, Sergiyko SV, Demenkov PS, Veryaskina YA et al. Could SLC26A7 Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma? Diagnostics. 2024 Dec;14(23):2652. doi: 10.3390/diagnostics14232652

Author

Titov, Sergei E. ; Kozorezova, Evgeniya S. ; Lukyanov, Sergei A. et al. / Could SLC26A7 Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?. In: Diagnostics. 2024 ; Vol. 14, No. 23.

BibTeX

@article{26c424d41413434ba5c642e3593896ae,

title = "Could SLC26A7 Be a Promising Marker for Preoperative Diagnosis of High-Grade Papillary Thyroid Carcinoma?",

abstract = "Background/Objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers of high-grade papillary thyroid carcinoma (PTC HG), primarily because of a recent WHO reclassification and singling out of a separate entity: high-grade follicular cell-derived nonanaplastic thyroid carcinoma. Therefore, this work was aimed at identifying PTC HG-specific microRNAs and mRNAs that reliably distinguish them from differentiated papillary thyroid carcinoma in preoperative cytology specimens (fine-needle aspiration biopsies). Methods: A molecular genetic profile (expression levels of 14 genes and eight microRNAs) was studied in 110 cytology specimens from patients with PTC: 13 PTCs HG and 97 PTCs without features of HG. Results: Of the examined eight microRNAs and 14 genes, significant differences in the expression levels between the PTC and PTC HG groups were revealed for genes SLC26A7, TFF3, and TPO. Only one gene (SLC26A7) proved to be crucial for detecting PTC HG. It showed the largest area under the ROC curve (0.816) in differentiation between the PTC and PTC HG groups and was the key element of the decision tree by ensuring 54% sensitivity and 87.6% specificity. Conclusions: Early preoperative diagnosis of PTC HG in patients with early stages of this cancer type will allow clinicians to modify a treatment strategy toward a larger surgery volume and lymph node dissection and may provide indications for subsequent radioactive iodine therapy.",

keywords = "SLC26A7, high-grade carcinoma, molecular marker, papillary thyroid carcinoma, preoperative diagnosis",

author = "Titov, {Sergei E.} and Kozorezova, {Evgeniya S.} and Lukyanov, {Sergei A.} and Sergiyko, {Sergei V.} and Demenkov, {Pavel S.} and Veryaskina, {Yulia A.} and Vorobyev, {Sergey L.} and Sleptsov, {Ilya Valeryevich} and Chernikov, {Roman A.} and Timofeeva, {Natalia I.} and Barashkova, {Svetlana V.} and Lushnikova, {Elena L.} and Uspenskaya, {Anna A.} and Zolotoukho, {Anna V.} and Romanova, {Olga V.} and Zhimulev, {Igor F.}",

note = "This research was funded by the Russian Science Foundation, grant number 20-14-00074-P.",

year = "2024",

month = dec,

doi = "10.3390/diagnostics14232652",

language = "русский",

volume = "14",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "MDPI AG",

number = "23",