Cooling rate “window” in the crystallization of metacetamol form II

Standard

Cooling rate “window” in the crystallization of metacetamol form II. / Drebushchak, V. A.; McGregor, L.; Rychkov, D. A.

In: Journal of Thermal Analysis and Calorimetry, Vol. 127, No. 2, 01.02.2017, p. 1807-1814.

Research output: Contribution to journal › Article › peer-review

Harvard

Drebushchak, VA, McGregor, L & Rychkov, DA 2017, 'Cooling rate “window” in the crystallization of metacetamol form II', Journal of Thermal Analysis and Calorimetry, vol. 127, no. 2, pp. 1807-1814. https://doi.org/10.1007/s10973-016-5954-0

APA

Drebushchak, V. A., McGregor, L., & Rychkov, D. A. (2017). Cooling rate “window” in the crystallization of metacetamol form II. Journal of Thermal Analysis and Calorimetry, 127(2), 1807-1814. https://doi.org/10.1007/s10973-016-5954-0

Vancouver

Drebushchak VA, McGregor L, Rychkov DA. Cooling rate “window” in the crystallization of metacetamol form II. Journal of Thermal Analysis and Calorimetry. 2017 Feb 1;127(2):1807-1814. doi: 10.1007/s10973-016-5954-0

Author

Drebushchak, V. A. ; McGregor, L. ; Rychkov, D. A. / Cooling rate “window” in the crystallization of metacetamol form II. In: Journal of Thermal Analysis and Calorimetry. 2017 ; Vol. 127, No. 2. pp. 1807-1814.

BibTeX

@article{af9b446eb07443dfa44dd17f8ccf5a81,

title = "Cooling rate “window” in the crystallization of metacetamol form II",

abstract = "Melting and crystallization of metacetamol (C8H9NO2, N-(3-hydroxyphenyl)acetamide, structural isomer of paracetamol) were measured using DSC cycling heating–cooling between room temperature and 165 °C with constant heating rate of 6 °C min−1 and variable cooling rate ranging from 3 to 24 °C min−1. The selection of the cooling rate allows us to control the crystallization of metacetamol into one of its two polymorphs, I or II. Pure form II of metacetamol (recently discovered) is crystallized after the cooling rate of 6 °C min−1. Increase or decrease in the cooling rate suppresses the crystallization of the form II and produces the form I with remnant amorphous phase and a small impurity of the form II. The melting points and enthalpies of fusion are 420 K and 26.0 ± 1.3 kJ mol−1 for the form I and 399 K and 21.3 ± 1.1 kJ mol−1 for the form II, respectively.",

keywords = "Cooling rate, DSC, Metacetamol, Polymorphism, CALIBRATION, PRESSURE, GROWTH, PARACETAMOL, POLYMORPHISM, NUCLEATION",

author = "Drebushchak, {V. A.} and L. McGregor and Rychkov, {D. A.}",

note = "Publisher Copyright: {\textcopyright} 2016, Akad{\'e}miai Kiad{\'o}, Budapest, Hungary.",

year = "2017",

month = feb,

day = "1",

doi = "10.1007/s10973-016-5954-0",

language = "English",

volume = "127",

pages = "1807--1814",

journal = "Journal of Thermal Analysis and Calorimetry",

issn = "1388-6150",

publisher = "Springer Nature",

number = "2",

}

RIS

TY - JOUR

T1 - Cooling rate “window” in the crystallization of metacetamol form II

AU - Drebushchak, V. A.

AU - McGregor, L.

AU - Rychkov, D. A.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Melting and crystallization of metacetamol (C8H9NO2, N-(3-hydroxyphenyl)acetamide, structural isomer of paracetamol) were measured using DSC cycling heating–cooling between room temperature and 165 °C with constant heating rate of 6 °C min−1 and variable cooling rate ranging from 3 to 24 °C min−1. The selection of the cooling rate allows us to control the crystallization of metacetamol into one of its two polymorphs, I or II. Pure form II of metacetamol (recently discovered) is crystallized after the cooling rate of 6 °C min−1. Increase or decrease in the cooling rate suppresses the crystallization of the form II and produces the form I with remnant amorphous phase and a small impurity of the form II. The melting points and enthalpies of fusion are 420 K and 26.0 ± 1.3 kJ mol−1 for the form I and 399 K and 21.3 ± 1.1 kJ mol−1 for the form II, respectively.

AB - Melting and crystallization of metacetamol (C8H9NO2, N-(3-hydroxyphenyl)acetamide, structural isomer of paracetamol) were measured using DSC cycling heating–cooling between room temperature and 165 °C with constant heating rate of 6 °C min−1 and variable cooling rate ranging from 3 to 24 °C min−1. The selection of the cooling rate allows us to control the crystallization of metacetamol into one of its two polymorphs, I or II. Pure form II of metacetamol (recently discovered) is crystallized after the cooling rate of 6 °C min−1. Increase or decrease in the cooling rate suppresses the crystallization of the form II and produces the form I with remnant amorphous phase and a small impurity of the form II. The melting points and enthalpies of fusion are 420 K and 26.0 ± 1.3 kJ mol−1 for the form I and 399 K and 21.3 ± 1.1 kJ mol−1 for the form II, respectively.

KW - Cooling rate

KW - DSC

KW - Metacetamol

KW - Polymorphism

KW - CALIBRATION

KW - PRESSURE

KW - GROWTH

KW - PARACETAMOL

KW - POLYMORPHISM

KW - NUCLEATION

UR - http://www.scopus.com/inward/record.url?scp=84996526161&partnerID=8YFLogxK

U2 - 10.1007/s10973-016-5954-0

DO - 10.1007/s10973-016-5954-0

M3 - Article

AN - SCOPUS:84996526161

VL - 127

SP - 1807

EP - 1814

JO - Journal of Thermal Analysis and Calorimetry

JF - Journal of Thermal Analysis and Calorimetry

SN - 1388-6150

IS - 2

ER -

ID: 9024935