Research output: Contribution to journal › Article › peer-review
Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization : application to an AA'X spin system. / Rodin, Bogdan A.; Eills, James; Picazo-Frutos, Román et al.
In: Physical Chemistry Chemical Physics, Vol. 23, No. 12, 28.03.2021, p. 7125-7134.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization
T2 - application to an AA'X spin system
AU - Rodin, Bogdan A.
AU - Eills, James
AU - Picazo-Frutos, Román
AU - Sheberstov, Kirill F.
AU - Budker, Dmitry
AU - Ivanov, Konstantin L.
N1 - Publisher Copyright: © the Owner Societies 2021.
PY - 2021/3/28
Y1 - 2021/3/28
N2 - The field of magnetic resonance imaging with hyperpolarized contrast agents is rapidly expanding, and parahydrogen-induced polarization (PHIP) is emerging as an inexpensive and easy-to-implement method for generating the required hyperpolarized biomolecules. Hydrogenative PHIP delivers hyperpolarized proton spin order to a substrateviachemical addition of H2in the spin-singlet state, but it is typically necessary to transfer the proton polarization to a heteronucleus (usually13C) which has a longer spin lifetime. Adiabatic ultralow magnetic field manipulations can be used to induce the polarization transfer, but this is necessarily a slow process, which is undesirable since the spins continually relax back to thermal equilibrium. Here we demonstrate two constant-adiabaticity field sweep methods, one in which the field passes through zero, and one in which the field is swept from zero, for optimal polarization transfer on a model AA′X spin system, [1-13C]fumarate. We introduce a method for calculating the constant-adiabaticity magnetic field sweeps, and demonstrate that they enable approximately one order of magnitude faster spin-order conversion compared to linear sweeps. The present method can thus be utilized to manipulate nonthermal order in heteronuclear spin systems.
AB - The field of magnetic resonance imaging with hyperpolarized contrast agents is rapidly expanding, and parahydrogen-induced polarization (PHIP) is emerging as an inexpensive and easy-to-implement method for generating the required hyperpolarized biomolecules. Hydrogenative PHIP delivers hyperpolarized proton spin order to a substrateviachemical addition of H2in the spin-singlet state, but it is typically necessary to transfer the proton polarization to a heteronucleus (usually13C) which has a longer spin lifetime. Adiabatic ultralow magnetic field manipulations can be used to induce the polarization transfer, but this is necessarily a slow process, which is undesirable since the spins continually relax back to thermal equilibrium. Here we demonstrate two constant-adiabaticity field sweep methods, one in which the field passes through zero, and one in which the field is swept from zero, for optimal polarization transfer on a model AA′X spin system, [1-13C]fumarate. We introduce a method for calculating the constant-adiabaticity magnetic field sweeps, and demonstrate that they enable approximately one order of magnitude faster spin-order conversion compared to linear sweeps. The present method can thus be utilized to manipulate nonthermal order in heteronuclear spin systems.
UR - http://www.scopus.com/inward/record.url?scp=85103685764&partnerID=8YFLogxK
U2 - 10.1039/d0cp06581a
DO - 10.1039/d0cp06581a
M3 - Article
C2 - 33876078
AN - SCOPUS:85103685764
VL - 23
SP - 7125
EP - 7134
JO - Physical Chemistry Chemical Physics
JF - Physical Chemistry Chemical Physics
SN - 1463-9076
IS - 12
ER -
ID: 28334331