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Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization : application to an AA'X spin system. / Rodin, Bogdan A.; Eills, James; Picazo-Frutos, Román et al.

In: Physical Chemistry Chemical Physics, Vol. 23, No. 12, 28.03.2021, p. 7125-7134.

Research output: Contribution to journalArticlepeer-review

Harvard

Rodin, BA, Eills, J, Picazo-Frutos, R, Sheberstov, KF, Budker, D & Ivanov, KL 2021, 'Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization: application to an AA'X spin system', Physical Chemistry Chemical Physics, vol. 23, no. 12, pp. 7125-7134. https://doi.org/10.1039/d0cp06581a

APA

Rodin, B. A., Eills, J., Picazo-Frutos, R., Sheberstov, K. F., Budker, D., & Ivanov, K. L. (2021). Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization: application to an AA'X spin system. Physical Chemistry Chemical Physics, 23(12), 7125-7134. https://doi.org/10.1039/d0cp06581a

Vancouver

Rodin BA, Eills J, Picazo-Frutos R, Sheberstov KF, Budker D, Ivanov KL. Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization: application to an AA'X spin system. Physical Chemistry Chemical Physics. 2021 Mar 28;23(12):7125-7134. doi: 10.1039/d0cp06581a

Author

Rodin, Bogdan A. ; Eills, James ; Picazo-Frutos, Román et al. / Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization : application to an AA'X spin system. In: Physical Chemistry Chemical Physics. 2021 ; Vol. 23, No. 12. pp. 7125-7134.

BibTeX

@article{493ebef709f8434598c2ab84638d3b81,
title = "Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization: application to an AA'X spin system",
abstract = "The field of magnetic resonance imaging with hyperpolarized contrast agents is rapidly expanding, and parahydrogen-induced polarization (PHIP) is emerging as an inexpensive and easy-to-implement method for generating the required hyperpolarized biomolecules. Hydrogenative PHIP delivers hyperpolarized proton spin order to a substrateviachemical addition of H2in the spin-singlet state, but it is typically necessary to transfer the proton polarization to a heteronucleus (usually13C) which has a longer spin lifetime. Adiabatic ultralow magnetic field manipulations can be used to induce the polarization transfer, but this is necessarily a slow process, which is undesirable since the spins continually relax back to thermal equilibrium. Here we demonstrate two constant-adiabaticity field sweep methods, one in which the field passes through zero, and one in which the field is swept from zero, for optimal polarization transfer on a model AA′X spin system, [1-13C]fumarate. We introduce a method for calculating the constant-adiabaticity magnetic field sweeps, and demonstrate that they enable approximately one order of magnitude faster spin-order conversion compared to linear sweeps. The present method can thus be utilized to manipulate nonthermal order in heteronuclear spin systems.",
author = "Rodin, {Bogdan A.} and James Eills and Rom{\'a}n Picazo-Frutos and Sheberstov, {Kirill F.} and Dmitry Budker and Ivanov, {Konstantin L.}",
note = "Publisher Copyright: {\textcopyright} the Owner Societies 2021.",
year = "2021",
month = mar,
day = "28",
doi = "10.1039/d0cp06581a",
language = "English",
volume = "23",
pages = "7125--7134",
journal = "Physical Chemistry Chemical Physics",
issn = "1463-9076",
publisher = "Royal Society of Chemistry",
number = "12",

}

RIS

TY - JOUR

T1 - Constant-adiabaticity ultralow magnetic field manipulations of parahydrogen-induced polarization

T2 - application to an AA'X spin system

AU - Rodin, Bogdan A.

AU - Eills, James

AU - Picazo-Frutos, Román

AU - Sheberstov, Kirill F.

AU - Budker, Dmitry

AU - Ivanov, Konstantin L.

N1 - Publisher Copyright: © the Owner Societies 2021.

PY - 2021/3/28

Y1 - 2021/3/28

N2 - The field of magnetic resonance imaging with hyperpolarized contrast agents is rapidly expanding, and parahydrogen-induced polarization (PHIP) is emerging as an inexpensive and easy-to-implement method for generating the required hyperpolarized biomolecules. Hydrogenative PHIP delivers hyperpolarized proton spin order to a substrateviachemical addition of H2in the spin-singlet state, but it is typically necessary to transfer the proton polarization to a heteronucleus (usually13C) which has a longer spin lifetime. Adiabatic ultralow magnetic field manipulations can be used to induce the polarization transfer, but this is necessarily a slow process, which is undesirable since the spins continually relax back to thermal equilibrium. Here we demonstrate two constant-adiabaticity field sweep methods, one in which the field passes through zero, and one in which the field is swept from zero, for optimal polarization transfer on a model AA′X spin system, [1-13C]fumarate. We introduce a method for calculating the constant-adiabaticity magnetic field sweeps, and demonstrate that they enable approximately one order of magnitude faster spin-order conversion compared to linear sweeps. The present method can thus be utilized to manipulate nonthermal order in heteronuclear spin systems.

AB - The field of magnetic resonance imaging with hyperpolarized contrast agents is rapidly expanding, and parahydrogen-induced polarization (PHIP) is emerging as an inexpensive and easy-to-implement method for generating the required hyperpolarized biomolecules. Hydrogenative PHIP delivers hyperpolarized proton spin order to a substrateviachemical addition of H2in the spin-singlet state, but it is typically necessary to transfer the proton polarization to a heteronucleus (usually13C) which has a longer spin lifetime. Adiabatic ultralow magnetic field manipulations can be used to induce the polarization transfer, but this is necessarily a slow process, which is undesirable since the spins continually relax back to thermal equilibrium. Here we demonstrate two constant-adiabaticity field sweep methods, one in which the field passes through zero, and one in which the field is swept from zero, for optimal polarization transfer on a model AA′X spin system, [1-13C]fumarate. We introduce a method for calculating the constant-adiabaticity magnetic field sweeps, and demonstrate that they enable approximately one order of magnitude faster spin-order conversion compared to linear sweeps. The present method can thus be utilized to manipulate nonthermal order in heteronuclear spin systems.

UR - http://www.scopus.com/inward/record.url?scp=85103685764&partnerID=8YFLogxK

U2 - 10.1039/d0cp06581a

DO - 10.1039/d0cp06581a

M3 - Article

C2 - 33876078

AN - SCOPUS:85103685764

VL - 23

SP - 7125

EP - 7134

JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

SN - 1463-9076

IS - 12

ER -

ID: 28334331