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Computational modeling of the cell-autonomous mammalian circadian oscillator. / Podkolodnaya, Olga A.; Tverdokhleb, Natalya N.; Podkolodnyy, Nikolay L.

In: BMC Systems Biology, Vol. 11, No. Suppl 1, 18, 24.02.2017, p. 379.

Research output: Contribution to journal › Article › peer-review

Harvard

Podkolodnaya, OA, Tverdokhleb, NN & Podkolodnyy, NL 2017, 'Computational modeling of the cell-autonomous mammalian circadian oscillator', BMC Systems Biology, vol. 11, no. Suppl 1, 18, pp. 379. https://doi.org/10.1186/s12918-016-0379-8

APA

Podkolodnaya, O. A., Tverdokhleb, N. N., & Podkolodnyy, N. L. (2017). Computational modeling of the cell-autonomous mammalian circadian oscillator. BMC Systems Biology, 11(Suppl 1), 379. [18]. https://doi.org/10.1186/s12918-016-0379-8

Vancouver

Podkolodnaya OA, Tverdokhleb NN, Podkolodnyy NL. Computational modeling of the cell-autonomous mammalian circadian oscillator. BMC Systems Biology. 2017 Feb 24;11(Suppl 1):379. 18. doi: 10.1186/s12918-016-0379-8

Author

Podkolodnaya, Olga A. ; Tverdokhleb, Natalya N. ; Podkolodnyy, Nikolay L. / Computational modeling of the cell-autonomous mammalian circadian oscillator. In: BMC Systems Biology. 2017 ; Vol. 11, No. Suppl 1. pp. 379.

BibTeX

@article{e424c54b4a0d4791810640760b890140,
title = "Computational modeling of the cell-autonomous mammalian circadian oscillator",
abstract = "This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.",
keywords = "Mammalian circadian oscillator, Mathematical modeling, Circadian Clocks/genetics, Animals, Models, Biological, Gene Expression Regulation, Mammals/genetics, Mutation, PARAMETER-ESTIMATION, CYCLE OSCILLATORS, TRANSCRIPTION, ROBUST, RIBOSOME PROFILING REVEALS, PERIOD, SENSITIVITY-ANALYSIS, GENE-EXPRESSION, CLOCK, SYSTEMS BIOLOGY",
author = "Podkolodnaya, {Olga A.} and Tverdokhleb, {Natalya N.} and Podkolodnyy, {Nikolay L.}",
note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = feb,
day = "24",
doi = "10.1186/s12918-016-0379-8",
language = "English",
volume = "11",
pages = "379",
journal = "BMC Systems Biology",
issn = "1752-0509",
publisher = "BioMed Central Ltd.",
number = "Suppl 1",

}

RIS

TY - JOUR

T1 - Computational modeling of the cell-autonomous mammalian circadian oscillator

AU - Podkolodnaya, Olga A.

AU - Tverdokhleb, Natalya N.

AU - Podkolodnyy, Nikolay L.

N1 - Publisher Copyright: © 2017 The Author(s).

PY - 2017/2/24

Y1 - 2017/2/24

N2 - This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.

AB - This review summarizes various mathematical models of cell-autonomous mammalian circadian clock. We present the basics necessary for understanding of the cell-autonomous mammalian circadian oscillator, modern experimental data essential for its reconstruction and some special problems related to the validation of mathematical circadian oscillator models. This work compares existing mathematical models of circadian oscillator and the results of the computational studies of the oscillating systems. Finally, we discuss applications of the mathematical models of mammalian circadian oscillator for solving specific problems in circadian rhythm biology.

KW - Mammalian circadian oscillator

KW - Mathematical modeling

KW - Circadian Clocks/genetics

KW - Animals

KW - Models, Biological

KW - Gene Expression Regulation

KW - Mammals/genetics

KW - Mutation

KW - PARAMETER-ESTIMATION

KW - CYCLE OSCILLATORS

KW - TRANSCRIPTION

KW - ROBUST

KW - RIBOSOME PROFILING REVEALS

KW - PERIOD

KW - SENSITIVITY-ANALYSIS

KW - GENE-EXPRESSION

KW - CLOCK

KW - SYSTEMS BIOLOGY

UR - http://www.scopus.com/inward/record.url?scp=85013831092&partnerID=8YFLogxK

U2 - 10.1186/s12918-016-0379-8

DO - 10.1186/s12918-016-0379-8

M3 - Article

C2 - 28466791

AN - SCOPUS:85013831092

VL - 11

SP - 379

JO - BMC Systems Biology

JF - BMC Systems Biology

SN - 1752-0509

IS - Suppl 1

M1 - 18

ER -

ID: 10303975