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Comprehensive analysis of telomerase inhibition by gallotannin. / Savelyev, Nikita; Baykuzina, Polina; Dokudovskaya, Svetlana et al.

In: Oncotarget, Vol. 9, No. 27, 10.04.2018, p. 18712-18719.

Research output: Contribution to journal › Article › peer-review

Harvard

Savelyev, N, Baykuzina, P, Dokudovskaya, S, Lavrik, O, Rubtsova, M & Dontsova, O 2018, 'Comprehensive analysis of telomerase inhibition by gallotannin', Oncotarget, vol. 9, no. 27, pp. 18712-18719. https://doi.org/10.18632/oncotarget.24642

APA

Savelyev, N., Baykuzina, P., Dokudovskaya, S., Lavrik, O., Rubtsova, M., & Dontsova, O. (2018). Comprehensive analysis of telomerase inhibition by gallotannin. Oncotarget, 9(27), 18712-18719. https://doi.org/10.18632/oncotarget.24642

Vancouver

Savelyev N, Baykuzina P, Dokudovskaya S, Lavrik O, Rubtsova M, Dontsova O. Comprehensive analysis of telomerase inhibition by gallotannin. Oncotarget. 2018 Apr 10;9(27):18712-18719. doi: 10.18632/oncotarget.24642

Author

Savelyev, Nikita ; Baykuzina, Polina ; Dokudovskaya, Svetlana et al. / Comprehensive analysis of telomerase inhibition by gallotannin. In: Oncotarget. 2018 ; Vol. 9, No. 27. pp. 18712-18719.

BibTeX

@article{9454cf3c9b444f3c96619d2315dcf3ae,
title = "Comprehensive analysis of telomerase inhibition by gallotannin",
abstract = "Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound.",
keywords = "Gallotannin, Inhibition, Poly(ADP-ribosy)lation, Telomerase, Telomere",
author = "Nikita Savelyev and Polina Baykuzina and Svetlana Dokudovskaya and Olga Lavrik and Maria Rubtsova and Olga Dontsova",
year = "2018",
month = apr,
day = "10",
doi = "10.18632/oncotarget.24642",
language = "English",
volume = "9",
pages = "18712--18719",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "27",

}

RIS

TY - JOUR

T1 - Comprehensive analysis of telomerase inhibition by gallotannin

AU - Savelyev, Nikita

AU - Baykuzina, Polina

AU - Dokudovskaya, Svetlana

AU - Lavrik, Olga

AU - Rubtsova, Maria

AU - Dontsova, Olga

PY - 2018/4/10

Y1 - 2018/4/10

N2 - Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound.

AB - Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound.

KW - Gallotannin

KW - Inhibition

KW - Poly(ADP-ribosy)lation

KW - Telomerase

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=85045220756&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.24642

DO - 10.18632/oncotarget.24642

M3 - Article

C2 - 29721155

AN - SCOPUS:85045220756

VL - 9

SP - 18712

EP - 18719

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 27

ER -

ID: 12475285