Research output: Contribution to journal › Article › peer-review
Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients. / Tamkovich, S. N.; Yunusova, N. V.; Somov, A. K. et al.
In: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Vol. 12, No. 2, 01.04.2018, p. 151-155.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients
AU - Tamkovich, S. N.
AU - Yunusova, N. V.
AU - Somov, A. K.
AU - Afanas’ev, S. G.
AU - Kakurina, G. V.
AU - Kolegova, E. S.
AU - Tugutova, E. A.
AU - Laktionov, P. P.
AU - Kondakova, I. V.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Pre-selection of tumor exosomes from a total pool of circulating microvesicles is an important stage required to increase sensitivity and specificity of the developing methods for diagnostics of oncological diseases. In this study, universal proteins characterized by increased expression in plasma exosomes have been identified in patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will help to develop a simple and high-performance method of affinity isolation of tumor exosomes.
AB - Pre-selection of tumor exosomes from a total pool of circulating microvesicles is an important stage required to increase sensitivity and specificity of the developing methods for diagnostics of oncological diseases. In this study, universal proteins characterized by increased expression in plasma exosomes have been identified in patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will help to develop a simple and high-performance method of affinity isolation of tumor exosomes.
KW - colorectal cancer
KW - exosomes
KW - flow cytometry
KW - head and neck squamous cell carcinoma
KW - lung cancer
KW - protein spectrum
KW - transmission electron microscopy
UR - http://www.scopus.com/inward/record.url?scp=85047834580&partnerID=8YFLogxK
U2 - 10.1134/S1990750818020130
DO - 10.1134/S1990750818020130
M3 - Article
AN - SCOPUS:85047834580
VL - 12
SP - 151
EP - 155
JO - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
JF - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
SN - 1990-7508
IS - 2
ER -
ID: 13686349