Research output: Contribution to journal › Review article › peer-review
Comparative sub-population analysis of exosomes from blood plasma of cancer patients. / Tamkovich, S. N.; Yunusova, N. V.; Somov, A. K. et al.
In: Biomeditsinskaya Khimiya, Vol. 64, No. 1, 01.01.2018, p. 110-114.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Comparative sub-population analysis of exosomes from blood plasma of cancer patients
AU - Tamkovich, S. N.
AU - Yunusova, N. V.
AU - Somov, A. K.
AU - Afanas'ev, S. G.
AU - Kakurina, G. V.
AU - Kolegova, E. S.
AU - Tugurova, E. A.
AU - Laktionov, P. P.
AU - Kondakova, I. V.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles is required. In the present work, universal proteins have been identified, their expression has been increased in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will further develop a simple and high-performance method of affinity isolation of tumor exosomes.
AB - To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles is required. In the present work, universal proteins have been identified, their expression has been increased in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will further develop a simple and high-performance method of affinity isolation of tumor exosomes.
KW - Colorectal cancer
KW - Exosomes
KW - Flow cytometry
KW - Head and neck squamous cell carcinoma
KW - Lung cancer
KW - Proteins
KW - Transmission electron microscopy
KW - Cell-Derived Microparticles
KW - Exosomes
KW - Humans
KW - Lung Neoplasms
KW - Proteins
UR - http://www.scopus.com/inward/record.url?scp=85043476268&partnerID=8YFLogxK
U2 - 10.18097/PBMC20186401110
DO - 10.18097/PBMC20186401110
M3 - Review article
C2 - 29460840
AN - SCOPUS:85043476268
VL - 64
SP - 110
EP - 114
JO - Biomeditsinskaya Khimiya
JF - Biomeditsinskaya Khimiya
SN - 2310-6905
IS - 1
ER -
ID: 10426576