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Cobalt complexes with biguanide derivatives – Synthesis, structure and antiviral activity. / Kirin, V. P.; Demkin, A. G.; Sukhikh, T. S. et al.
In: Journal of Molecular Structure, Vol. 1250, 131486, 15.02.2022.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Cobalt complexes with biguanide derivatives – Synthesis, structure and antiviral activity
AU - Kirin, V. P.
AU - Demkin, A. G.
AU - Sukhikh, T. S.
AU - Ilyicheva, T. N.
AU - Maksakov, V. A.
N1 - Funding Information: The research was supported by the Ministry of Science and Higher Education of the Russian Federation (project № 121031700321-3 and № 121031700313-8 ). Publisher Copyright: © 2021
PY - 2022/2/15
Y1 - 2022/2/15
N2 - The reactions of biguanide derivatives NRR′(NH)CNHC(NH)NH2 ((RR′bigH: R, R′ = Bui, H; Pr, H; -CH2CH2OCH2CH2-) with cobalt salts have been studied. For the Co3+ ion, tris-chelate complexes with neutral bidentate coordinated derivatives of biguanides ([Co(RR′bigH)3]Cl3 (R, R′= Bui, H; Pr, H)) were obtained, as well as a complex with bidentate coordinated deprotonated morpholine derivative of biguanide [Co((RR′bigH)3] (R, R′= -CH2CH2OCH2CH2-). In the case of Co2+ ion, the [Co(MorphbigH2)Cl3] complex was obtained, in which the ligand is protonated and monodentate coordinated. The structure of the two complexes, [Co(iBuHbigH)3]Cl3 and [Co(MorphbigH2)Cl3], was determined using single crystal X-ray diffraction analysis. The newly obtained compounds, in contrast to the complexes obtained by us earlier, did not show activity against the influenza virus but turned out to be active against the second type of herpes virus. A preliminary analysis of the influence of the metal complex structures and functional groups of its ligands on the antiviral activity indicates that the number of free functional groups in ligands plays a more important role than of the metal complex structures.
AB - The reactions of biguanide derivatives NRR′(NH)CNHC(NH)NH2 ((RR′bigH: R, R′ = Bui, H; Pr, H; -CH2CH2OCH2CH2-) with cobalt salts have been studied. For the Co3+ ion, tris-chelate complexes with neutral bidentate coordinated derivatives of biguanides ([Co(RR′bigH)3]Cl3 (R, R′= Bui, H; Pr, H)) were obtained, as well as a complex with bidentate coordinated deprotonated morpholine derivative of biguanide [Co((RR′bigH)3] (R, R′= -CH2CH2OCH2CH2-). In the case of Co2+ ion, the [Co(MorphbigH2)Cl3] complex was obtained, in which the ligand is protonated and monodentate coordinated. The structure of the two complexes, [Co(iBuHbigH)3]Cl3 and [Co(MorphbigH2)Cl3], was determined using single crystal X-ray diffraction analysis. The newly obtained compounds, in contrast to the complexes obtained by us earlier, did not show activity against the influenza virus but turned out to be active against the second type of herpes virus. A preliminary analysis of the influence of the metal complex structures and functional groups of its ligands on the antiviral activity indicates that the number of free functional groups in ligands plays a more important role than of the metal complex structures.
KW - Antiviral activity
KW - Biguanide
KW - Cobalt complexes
KW - XRD
UR - http://www.scopus.com/inward/record.url?scp=85116871806&partnerID=8YFLogxK
U2 - 10.1016/j.molstruc.2021.131486
DO - 10.1016/j.molstruc.2021.131486
M3 - Article
AN - SCOPUS:85116871806
VL - 1250
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
SN - 0022-2860
M1 - 131486
ER -
ID: 34400473