Chronic gamma radiation resistance in fungi correlates with resistance to chromium and elevated temperatures, but not with resistance to acute irradiation. / Shuryak, Igor; Tkavc, Rok; Matrosova, Vera Y. et al.
In: Scientific Reports, Vol. 9, No. 1, 11361, 06.08.2019, p. 11361.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Chronic gamma radiation resistance in fungi correlates with resistance to chromium and elevated temperatures, but not with resistance to acute irradiation
AU - Shuryak, Igor
AU - Tkavc, Rok
AU - Matrosova, Vera Y.
AU - Volpe, Robert P.
AU - Grichenko, Olga
AU - Klimenkova, Polina
AU - Conze, Isabel H.
AU - Balygina, Irina A.
AU - Gaidamakova, Elena K.
AU - Daly, Michael J.
PY - 2019/8/6
Y1 - 2019/8/6
N2 - Exposure to chronic ionizing radiation (CIR) from nuclear power plant accidents, acts of terrorism, and space exploration poses serious threats to humans. Fungi are a group of highly radiation-resistant eukaryotes, and an understanding of fungal CIR resistance mechanisms holds the prospect of protecting humans. We compared the abilities of 95 wild-type yeast and dimorphic fungal isolates, representing diverse Ascomycota and Basidiomycota, to resist exposure to five environmentally-relevant stressors: CIR (long-duration growth under 36 Gy/h) and acute (10 kGy/h) ionizing radiation (IR), heavy metals (chromium, mercury), elevated temperature (up to 50 °C), and low pH (2.3). To quantify associations between resistances to CIR and these other stressors, we used correlation analysis, logistic regression with multi-model inference, and customized machine learning. The results suggest that resistance to acute IR in fungi is not strongly correlated with the ability of a given fungal isolate to grow under CIR. Instead, the strongest predictors of CIR resistance in fungi were resistance to chromium (III) and to elevated temperature. These results suggest fundamental differences between the mechanisms of resistance to chronic and acute radiation. Convergent evolution towards radioresistance among genetically distinct groups of organisms is considered here.
AB - Exposure to chronic ionizing radiation (CIR) from nuclear power plant accidents, acts of terrorism, and space exploration poses serious threats to humans. Fungi are a group of highly radiation-resistant eukaryotes, and an understanding of fungal CIR resistance mechanisms holds the prospect of protecting humans. We compared the abilities of 95 wild-type yeast and dimorphic fungal isolates, representing diverse Ascomycota and Basidiomycota, to resist exposure to five environmentally-relevant stressors: CIR (long-duration growth under 36 Gy/h) and acute (10 kGy/h) ionizing radiation (IR), heavy metals (chromium, mercury), elevated temperature (up to 50 °C), and low pH (2.3). To quantify associations between resistances to CIR and these other stressors, we used correlation analysis, logistic regression with multi-model inference, and customized machine learning. The results suggest that resistance to acute IR in fungi is not strongly correlated with the ability of a given fungal isolate to grow under CIR. Instead, the strongest predictors of CIR resistance in fungi were resistance to chromium (III) and to elevated temperature. These results suggest fundamental differences between the mechanisms of resistance to chronic and acute radiation. Convergent evolution towards radioresistance among genetically distinct groups of organisms is considered here.
KW - CELLS
KW - DEINOCOCCUS-RADIODURANS
KW - IONIZING-RADIATION
KW - MECHANISMS
KW - MN2+
KW - MN2+-PEPTIDE COMPLEX
KW - OXIDATIVE STRESS RESISTANCE
KW - PROTEIN OXIDATION
KW - RADIORESISTANCE
UR - http://www.scopus.com/inward/record.url?scp=85070288710&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-47007-9
DO - 10.1038/s41598-019-47007-9
M3 - Article
C2 - 31388021
AN - SCOPUS:85070288710
VL - 9
SP - 11361
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 11361
ER -
ID: 21256727