Research output: Contribution to journal › Article › peer-review
Chiral autoamplification meets dynamic chirality control to suggest nonautocatalytic chemical model of prebiotic chirality amplification. / Talsi, Evgenii P.; Bryliakova, Anna A.; Ottenbacher, Roman V. et al.
In: Research, Vol. 2019, 4756025, 04.11.2019.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Chiral autoamplification meets dynamic chirality control to suggest nonautocatalytic chemical model of prebiotic chirality amplification
AU - Talsi, Evgenii P.
AU - Bryliakova, Anna A.
AU - Ottenbacher, Roman V.
AU - Rybalova, Tatyana V.
AU - Bryliakov, Konstantin P.
N1 - Publisher Copyright: Copyright © 2019 Evgenii P. Talsi et al.
PY - 2019/11/4
Y1 - 2019/11/4
N2 - Oxidative kinetic resolution of 1-phenylethanol in the presence of manganese complexes, bearing conformationally nonrigid achiral bis-amine-bis-pyridine ligands, in the absence of any exogenous chiral additives, is reported. The only driving force for the chiral discrimination is the small initial enantiomeric imbalance of the scalemic (nonracemic) substrate: the latter dynamically controls the chirality of the catalyst, serving itself as the chiral auxiliary. In effect, the ee of 1-phenylethanol increases monotonously over the reaction course. This dynamic control of catalyst chirality by the substrate has been unprecedented; a consistent kinetic model for this process is presented. The reported catalyzed substrate self-enantioenrichment mechanism is discussed in relation to the problem of prebiotic chirality amplification.
AB - Oxidative kinetic resolution of 1-phenylethanol in the presence of manganese complexes, bearing conformationally nonrigid achiral bis-amine-bis-pyridine ligands, in the absence of any exogenous chiral additives, is reported. The only driving force for the chiral discrimination is the small initial enantiomeric imbalance of the scalemic (nonracemic) substrate: the latter dynamically controls the chirality of the catalyst, serving itself as the chiral auxiliary. In effect, the ee of 1-phenylethanol increases monotonously over the reaction course. This dynamic control of catalyst chirality by the substrate has been unprecedented; a consistent kinetic model for this process is presented. The reported catalyzed substrate self-enantioenrichment mechanism is discussed in relation to the problem of prebiotic chirality amplification.
UR - http://www.scopus.com/inward/record.url?scp=85078782358&partnerID=8YFLogxK
U2 - 10.34133/2019/4756025
DO - 10.34133/2019/4756025
M3 - Article
C2 - 31922134
AN - SCOPUS:85078782358
VL - 2019
JO - Research
JF - Research
SN - 2639-5274
M1 - 4756025
ER -
ID: 22621716