Chemical approach to the design of effective antidiabetic agents

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Chemical approach to the design of effective antidiabetic agents. / Rogachev, Artem D.; Kuranov, Sergey O.; Salakhutdinov, Nariman F.

In: Russian Chemical Reviews, Vol. 85, No. 12, 2016, p. 1313-1337.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{7aec60224ea546aeaa54a1bb1e6db68f,

title = "Chemical approach to the design of effective antidiabetic agents",

abstract = "The review discusses the literature data on the structures of hypoglycemic compounds with different mechanisms of action. It is shown that many drugs acting on different biological targets have similar or identical structural moieties. Compounds containing a sulfonyl group, a 3-phenylpropanoic acid moiety or the indane ring, as well as derivatives of heterocyclic systems (quinoline, isoquinoline, benzoxazine, thiazolidine and so on) are presented. The approach to the design of multi target hypoglycemic drugs by combining different pharmacophoric groups in one molecule is considered. The prospects of the use of these agents for the treatment of type 2 diabetes are discussed.The bibliography includes 177 references.",

keywords = "ACTIVATED-RECEPTOR-GAMMA, 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1, DIPEPTIDYL-PEPTIDASE-IV, PPAR-GAMMA, NON-THIAZOLIDINEDIONE, BIOLOGICAL-ACTIVITIES, IN-VITRO, LYSOPHOSPHATIDIC ACID, INSULIN SENSITIVITY, MEDICINAL CHEMISTRY",

author = "Rogachev, {Artem D.} and Kuranov, {Sergey O.} and Salakhutdinov, {Nariman F.}",

note = "Publisher Copyright: {\textcopyright} 2016 Russian Academy of Sciences and Turpion Ltd.",

year = "2016",

doi = "10.1070/RCR4624",

language = "English",

volume = "85",

pages = "1313--1337",

journal = "Russian Chemical Reviews",

issn = "0036-021X",

publisher = "Turpion Ltd.",

number = "12",

}

RIS

TY - JOUR

T1 - Chemical approach to the design of effective antidiabetic agents

AU - Rogachev, Artem D.

AU - Kuranov, Sergey O.

AU - Salakhutdinov, Nariman F.

PY - 2016

Y1 - 2016

N2 - The review discusses the literature data on the structures of hypoglycemic compounds with different mechanisms of action. It is shown that many drugs acting on different biological targets have similar or identical structural moieties. Compounds containing a sulfonyl group, a 3-phenylpropanoic acid moiety or the indane ring, as well as derivatives of heterocyclic systems (quinoline, isoquinoline, benzoxazine, thiazolidine and so on) are presented. The approach to the design of multi target hypoglycemic drugs by combining different pharmacophoric groups in one molecule is considered. The prospects of the use of these agents for the treatment of type 2 diabetes are discussed.The bibliography includes 177 references.

AB - The review discusses the literature data on the structures of hypoglycemic compounds with different mechanisms of action. It is shown that many drugs acting on different biological targets have similar or identical structural moieties. Compounds containing a sulfonyl group, a 3-phenylpropanoic acid moiety or the indane ring, as well as derivatives of heterocyclic systems (quinoline, isoquinoline, benzoxazine, thiazolidine and so on) are presented. The approach to the design of multi target hypoglycemic drugs by combining different pharmacophoric groups in one molecule is considered. The prospects of the use of these agents for the treatment of type 2 diabetes are discussed.The bibliography includes 177 references.

KW - ACTIVATED-RECEPTOR-GAMMA

KW - 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1

KW - DIPEPTIDYL-PEPTIDASE-IV

KW - PPAR-GAMMA

KW - NON-THIAZOLIDINEDIONE

KW - BIOLOGICAL-ACTIVITIES

KW - IN-VITRO

KW - LYSOPHOSPHATIDIC ACID

KW - INSULIN SENSITIVITY

KW - MEDICINAL CHEMISTRY

UR - http://www.scopus.com/inward/record.url?scp=85007475087&partnerID=8YFLogxK

U2 - 10.1070/RCR4624

DO - 10.1070/RCR4624

M3 - Review article

VL - 85

SP - 1313

EP - 1337

JO - Russian Chemical Reviews

JF - Russian Chemical Reviews

SN - 0036-021X

IS - 12

ER -

ID: 25566302