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Chelidonic Acid and Its Derivatives from Saussurea Controversa : Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro. / Avdeeva, Elena; Shults, Elvira; Rybalova, Tatyana et al.

In: Biomolecules, Vol. 9, No. 5, 189, 16.05.2019.

Research output: Contribution to journal › Article › peer-review

Harvard

Avdeeva, E, Shults, E, Rybalova, T, Reshetov, Y, Porokhova, E, Sukhodolo, I, Litvinova, L, Shupletsova, V, Khaziakhmatova, O, Khlusov, I, Guryev, A & Belousov, M 2019, 'Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro', Biomolecules, vol. 9, no. 5, 189. https://doi.org/10.3390/biom9050189

APA

Avdeeva, E., Shults, E., Rybalova, T., Reshetov, Y., Porokhova, E., Sukhodolo, I., Litvinova, L., Shupletsova, V., Khaziakhmatova, O., Khlusov, I., Guryev, A., & Belousov, M. (2019). Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro. Biomolecules, 9(5), [189]. https://doi.org/10.3390/biom9050189

Vancouver

Avdeeva E, Shults E, Rybalova T, Reshetov Y, Porokhova E, Sukhodolo I et al. Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro. Biomolecules. 2019 May 16;9(5):189. doi: 10.3390/biom9050189

Author

Avdeeva, Elena ; Shults, Elvira ; Rybalova, Tatyana et al. / Chelidonic Acid and Its Derivatives from Saussurea Controversa : Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro. In: Biomolecules. 2019 ; Vol. 9, No. 5.

BibTeX

@article{cbb55faa73a7463da88a04e75e7f47b3,
title = "Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro",
abstract = "4-oxo-4H-pyran-2.6-dicarboxylic acid (chelidonic acid, ChA) in the native state and in the complex with calcium [Ca(ChA)(H2O)3], named saucalchelin (CaChA), was isolated from the extract of Saussurea controversa leaves for the first time for the Asteraceae family. The structure of ChA was determined by NMR, MS and confirmed by X-ray analysis of its monomethyl ester, and CaChA was described by IR, ICP-MS, CHN analysis. The yield of ChA and CaChA was 45 mg/g and 70 mg/g of extract, respectively. The osteogenic activity of ChA, n-monobutyl ester of chelidonic acid, and CaChA has been studied in vitro in a 21-day culture of human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs) in a standard nutrient medium without osteogenic supplements. CaChA significantly stimulated the growth of cell mass and differentiation of hAMMSCs into osteoblasts with subsequent mineralization of the culture and it may be a promising substance for accelerating bone tissue regeneration and engineering.",
keywords = "4-oxo-4H-pyran-2.6-dicarboxylic acid esters, chelidonic acid, human multipotent mesenchymal stromal cells, Saussurea controversa DC (Asteraceae), X-ray diffraction analysis, INTERNATIONAL-SOCIETY, COMPLEXES, 4-oxo-4H-pyran-2, 6-dicarboxylic acid esters, ADIPOSE-TISSUE, Human multipotent mesenchymal stromal cells, Chelidonic acid",
author = "Elena Avdeeva and Elvira Shults and Tatyana Rybalova and Yaroslav Reshetov and Ekaterina Porokhova and Irina Sukhodolo and Larisa Litvinova and Valeria Shupletsova and Olga Khaziakhmatova and Igor Khlusov and Artem Guryev and Mikhail Belousov",
note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = may,
day = "16",
doi = "10.3390/biom9050189",
language = "English",
volume = "9",
journal = "Biomolecules",
issn = "2218-273X",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",

}

RIS

TY - JOUR

T1 - Chelidonic Acid and Its Derivatives from Saussurea Controversa

T2 - Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro

AU - Avdeeva, Elena

AU - Shults, Elvira

AU - Rybalova, Tatyana

AU - Reshetov, Yaroslav

AU - Porokhova, Ekaterina

AU - Sukhodolo, Irina

AU - Litvinova, Larisa

AU - Shupletsova, Valeria

AU - Khaziakhmatova, Olga

AU - Khlusov, Igor

AU - Guryev, Artem

AU - Belousov, Mikhail

N1 - Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2019/5/16

Y1 - 2019/5/16

N2 - 4-oxo-4H-pyran-2.6-dicarboxylic acid (chelidonic acid, ChA) in the native state and in the complex with calcium [Ca(ChA)(H2O)3], named saucalchelin (CaChA), was isolated from the extract of Saussurea controversa leaves for the first time for the Asteraceae family. The structure of ChA was determined by NMR, MS and confirmed by X-ray analysis of its monomethyl ester, and CaChA was described by IR, ICP-MS, CHN analysis. The yield of ChA and CaChA was 45 mg/g and 70 mg/g of extract, respectively. The osteogenic activity of ChA, n-monobutyl ester of chelidonic acid, and CaChA has been studied in vitro in a 21-day culture of human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs) in a standard nutrient medium without osteogenic supplements. CaChA significantly stimulated the growth of cell mass and differentiation of hAMMSCs into osteoblasts with subsequent mineralization of the culture and it may be a promising substance for accelerating bone tissue regeneration and engineering.

AB - 4-oxo-4H-pyran-2.6-dicarboxylic acid (chelidonic acid, ChA) in the native state and in the complex with calcium [Ca(ChA)(H2O)3], named saucalchelin (CaChA), was isolated from the extract of Saussurea controversa leaves for the first time for the Asteraceae family. The structure of ChA was determined by NMR, MS and confirmed by X-ray analysis of its monomethyl ester, and CaChA was described by IR, ICP-MS, CHN analysis. The yield of ChA and CaChA was 45 mg/g and 70 mg/g of extract, respectively. The osteogenic activity of ChA, n-monobutyl ester of chelidonic acid, and CaChA has been studied in vitro in a 21-day culture of human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs) in a standard nutrient medium without osteogenic supplements. CaChA significantly stimulated the growth of cell mass and differentiation of hAMMSCs into osteoblasts with subsequent mineralization of the culture and it may be a promising substance for accelerating bone tissue regeneration and engineering.

KW - 4-oxo-4H-pyran-2.6-dicarboxylic acid esters

KW - chelidonic acid

KW - human multipotent mesenchymal stromal cells

KW - Saussurea controversa DC (Asteraceae)

KW - X-ray diffraction analysis

KW - INTERNATIONAL-SOCIETY

KW - COMPLEXES

KW - 4-oxo-4H-pyran-2

KW - 6-dicarboxylic acid esters

KW - ADIPOSE-TISSUE

KW - Human multipotent mesenchymal stromal cells

KW - Chelidonic acid

UR - http://www.scopus.com/inward/record.url?scp=85066234373&partnerID=8YFLogxK

U2 - 10.3390/biom9050189

DO - 10.3390/biom9050189

M3 - Article

C2 - 31100934

AN - SCOPUS:85066234373

VL - 9

JO - Biomolecules

JF - Biomolecules

SN - 2218-273X

IS - 5

M1 - 189

ER -

ID: 20343495