Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
Chapter 21 : Fast Field-cycling NMR Experiments with Hyperpolarized Spins. / Kiryutin, Alexey S.; Ivanov, Konstantin L.; Yurkovskaya, Alexandra V. et al.
Optimizing NMR Methods for Structure Elucidation: Characterizing Natural Products and Other Organic Compounds. ed. / R Kimmich. 18. ed. Royal Society of Chemistry, 2018. p. 512-562 (New Developments in NMR; Vol. 2019-January, No. 18).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review
}
TY - CHAP
T1 - Chapter 21
T2 - Fast Field-cycling NMR Experiments with Hyperpolarized Spins
AU - Kiryutin, Alexey S.
AU - Ivanov, Konstantin L.
AU - Yurkovskaya, Alexandra V.
AU - Vieth, Hans Martin
PY - 2018
Y1 - 2018
N2 - This chapter gives an overview of field-cycling applications for the control of nuclear spin order in hyperpolarized spin ensembles. Such methods are used for strong signal enhancement in NMR spectroscopy, for the preservation of non-thermal order and for the analysis of the polarization process. We focus on techniques that are operative in the condensed phase and exploit processes based on light irradiation. Such techniques include optical nuclear polarization (ONP), chemically induced dynamic nuclear polarization (CIDNP) and optical pumping (OP). Alternatively, we start from the singlet spin order of para-hydrogen, the singlet spin isomer of the H2 molecule. This approach is known as para-hydrogen-induced polarization (PHIP) and in a slightly different version as signal amplification by reversible exchange (SABRE). Since in all methods polarization is transferred from primarily polarized spins to target spins, we also review existing methods for polarization transfer. After describing the theoretical framework, we present examples of instrumentation for field cycling in the range between 5 nT and 9.4 T, and subsequently discuss characteristic applications. Advantages and challenges of field cycling in spin hyperpolarization are discussed and perspectives in this field are addressed.
AB - This chapter gives an overview of field-cycling applications for the control of nuclear spin order in hyperpolarized spin ensembles. Such methods are used for strong signal enhancement in NMR spectroscopy, for the preservation of non-thermal order and for the analysis of the polarization process. We focus on techniques that are operative in the condensed phase and exploit processes based on light irradiation. Such techniques include optical nuclear polarization (ONP), chemically induced dynamic nuclear polarization (CIDNP) and optical pumping (OP). Alternatively, we start from the singlet spin order of para-hydrogen, the singlet spin isomer of the H2 molecule. This approach is known as para-hydrogen-induced polarization (PHIP) and in a slightly different version as signal amplification by reversible exchange (SABRE). Since in all methods polarization is transferred from primarily polarized spins to target spins, we also review existing methods for polarization transfer. After describing the theoretical framework, we present examples of instrumentation for field cycling in the range between 5 nT and 9.4 T, and subsequently discuss characteristic applications. Advantages and challenges of field cycling in spin hyperpolarization are discussed and perspectives in this field are addressed.
KW - OPTICAL NUCLEAR-POLARIZATION
KW - LEVEL ANTI-CROSSINGS
KW - PARAHYDROGEN INDUCED POLARIZATION
KW - CHEMICAL HYDROGEN ABSTRACTION
KW - MULTINUCLEAR RADICAL PAIRS
KW - SHUTTLE DNP SPECTROMETER
KW - DOPED FLUORENE CRYSTALS
KW - EXCITED TRIPLET-STATES
KW - TIME-RESOLVED CIDNP
KW - N-ACETYL HISTIDINE
UR - http://www.scopus.com/inward/record.url?scp=85056667254&partnerID=8YFLogxK
U2 - 10.1039/9781788012966-00512
DO - 10.1039/9781788012966-00512
M3 - Chapter
AN - SCOPUS:85056667254
SN - 978-1-78801-154-9
T3 - New Developments in NMR
SP - 512
EP - 562
BT - Optimizing NMR Methods for Structure Elucidation
A2 - Kimmich, R
PB - Royal Society of Chemistry
ER -
ID: 17470751