TY - JOUR

T1 - Changes in the Midbrain Neurobiological Responses to Lithium Chloride under Inflammatory Conditions

AU - Bannova, A. V.

AU - Shishkina, G. T.

AU - Komysheva, N. P.

AU - Dygalo, N. N.

N1 - This work was supported by RSF (no. 20-64-47013; LPS effects) and Ministry of Education and Science of the Russian Federation (FWNR-2022-0023; LiCl effects). Changes in the Midbrain Neurobiological Responses to Lithium Chloride under Inflammatory Conditions / A. V. Bannova, G. T. Shishkina, N. P. Komysheva, N. N. Dygalo // Neurochemical Journal. – 2023. – Vol. 17, No. 1. – P. 101-110. – DOI 10.1134/s1819712423010026.

PY - 2023

Y1 - 2023

N2 - Effectiveness of psychotropic drugs can be altered under inflammation however the mechanisms of the possible changes remain unclear. In order to clarify this issue, we compared effects of the mood stabilizer lithium chloride (LiCl) on anxiety and depressive-like behaviors, midbrain expression of pro-inflammatory, neuroplasticity and serotonergic markers under the normal and induced by repeated administration of lipopolysaccharide (LPS) inflammatory conditions. LiCl alone caused an antidepressant-like effect in the forced swim test and this effect was weakened in LPS-treated animals. LPS alone increased the markers of neuroinflammation among which expression of Iba-1 protein and IL-1β mRNA was not affected by LiCl co-treatment, whereas elevation in MMP-9 protein was even strengthened. The treatment with both, but not alone, LPS and LiCl increased BDNF expression, effect that was accompanied by a decrease in mRNA levels of GSK-3β. Up-regulating effects of LiCl alone on TPH2 mRNA expression were decreased under neuroinflammatory activation. The data suggest that the behavioral responses to LiCl can be modified during inflammation through pathways that involved changes in pro-inflammatory, neuroplasticity and serotonergic activities in the midbrain.

AB - Effectiveness of psychotropic drugs can be altered under inflammation however the mechanisms of the possible changes remain unclear. In order to clarify this issue, we compared effects of the mood stabilizer lithium chloride (LiCl) on anxiety and depressive-like behaviors, midbrain expression of pro-inflammatory, neuroplasticity and serotonergic markers under the normal and induced by repeated administration of lipopolysaccharide (LPS) inflammatory conditions. LiCl alone caused an antidepressant-like effect in the forced swim test and this effect was weakened in LPS-treated animals. LPS alone increased the markers of neuroinflammation among which expression of Iba-1 protein and IL-1β mRNA was not affected by LiCl co-treatment, whereas elevation in MMP-9 protein was even strengthened. The treatment with both, but not alone, LPS and LiCl increased BDNF expression, effect that was accompanied by a decrease in mRNA levels of GSK-3β. Up-regulating effects of LiCl alone on TPH2 mRNA expression were decreased under neuroinflammatory activation. The data suggest that the behavioral responses to LiCl can be modified during inflammation through pathways that involved changes in pro-inflammatory, neuroplasticity and serotonergic activities in the midbrain.

KW - LIPOPOLYSACCHARIDE

KW - LITHIUM CHLORIDE

KW - NEUROINFLAMMATION

KW - brain-derived neurotrophic factor

KW - ANTI-APOPTOTIC PROTEINS

KW - TRYPTOPHAN HYDROXYLASE 2

KW - NEUROSCIENCES

UR - https://www.mendeley.com/catalogue/7fbd9b3b-c3a3-34f1-a4b3-38428cb88aba/

UR - https://www.elibrary.ru/item.asp?id=61764166

U2 - 10.1134/s1819712423010026

DO - 10.1134/s1819712423010026

M3 - Article

VL - 17

SP - 101

EP - 110

JO - Neurochemical Journal

JF - Neurochemical Journal

SN - 1819-7124

IS - 1

ER -