Changes in Gene Expression and Neuroinflammation in the Hippocampus after Focal Brain Ischemia: Involvement in the Long-Term Cognitive and Mental Disorders

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Changes in Gene Expression and Neuroinflammation in the Hippocampus after Focal Brain Ischemia: Involvement in the Long-Term Cognitive and Mental Disorders. / Shishkina, Galina T.; Kalinina, Tatiana S.; Gulyaeva, Natalia V. et al.

In: Biochemistry (Moscow), Vol. 86, No. 6, 3, 06.2021, p. 657-666.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{b5468a4b366a486bb3502ef484a39104,

title = "Changes in Gene Expression and Neuroinflammation in the Hippocampus after Focal Brain Ischemia: Involvement in the Long-Term Cognitive and Mental Disorders",

abstract = "Ischemic brain injuries are accompanied by the long-term changes in gene expression in the hippocampus, the limbic system structure, involved in the regulation of key aspects of the higher nervous activity, such as cognitive functions and emotions. The altered expression of genes and proteins encoded by them may be related to the development of post-ischemic psycho-emotional and cognitive disturbances. Activation of neuroinflammation following stroke in the hippocampus has been suggested to play an essential role in induction of long-lasting consequences. Identification of changes in the gene expression patterns after ischemia and investigation of the dynamics of these changes in the hippocampus are the necessary first steps toward understanding molecular pathways responsible for the development of post-stroke cognitive impairments and mental pathologies.",

keywords = "cognitive impairment, depression, focal brain injuries, gene expression, hippocampus, neuroinflammation, Stroke/complications, Mental Disorders/etiology, Humans, Gene Expression Regulation, Cognition Disorders/etiology, Cognition, Inflammation, Animals, Brain Ischemia/complications, Brain Injuries, Hippocampus/metabolism, Depression/etiology",

author = "Shishkina, {Galina T.} and Kalinina, {Tatiana S.} and Gulyaeva, {Natalia V.} and Lanshakov, {Dmitry A.} and Dygalo, {Nikolay N.}",

note = "Funding Information: This work was supported by the Russian Science Foundation (project no. 20-64-47013) and by the State Budget Project 0259-2021-0015. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = jun,

doi = "10.1134/S0006297921060043",

language = "English",

volume = "86",

pages = "657--666",

journal = "Biochemistry (Moscow)",

issn = "0006-2979",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "6",

}

RIS

TY - JOUR

T1 - Changes in Gene Expression and Neuroinflammation in the Hippocampus after Focal Brain Ischemia: Involvement in the Long-Term Cognitive and Mental Disorders

AU - Shishkina, Galina T.

AU - Kalinina, Tatiana S.

AU - Gulyaeva, Natalia V.

AU - Lanshakov, Dmitry A.

AU - Dygalo, Nikolay N.

N1 - Funding Information: This work was supported by the Russian Science Foundation (project no. 20-64-47013) and by the State Budget Project 0259-2021-0015. Publisher Copyright: © 2021, The Author(s).

PY - 2021/6

Y1 - 2021/6

N2 - Ischemic brain injuries are accompanied by the long-term changes in gene expression in the hippocampus, the limbic system structure, involved in the regulation of key aspects of the higher nervous activity, such as cognitive functions and emotions. The altered expression of genes and proteins encoded by them may be related to the development of post-ischemic psycho-emotional and cognitive disturbances. Activation of neuroinflammation following stroke in the hippocampus has been suggested to play an essential role in induction of long-lasting consequences. Identification of changes in the gene expression patterns after ischemia and investigation of the dynamics of these changes in the hippocampus are the necessary first steps toward understanding molecular pathways responsible for the development of post-stroke cognitive impairments and mental pathologies.

AB - Ischemic brain injuries are accompanied by the long-term changes in gene expression in the hippocampus, the limbic system structure, involved in the regulation of key aspects of the higher nervous activity, such as cognitive functions and emotions. The altered expression of genes and proteins encoded by them may be related to the development of post-ischemic psycho-emotional and cognitive disturbances. Activation of neuroinflammation following stroke in the hippocampus has been suggested to play an essential role in induction of long-lasting consequences. Identification of changes in the gene expression patterns after ischemia and investigation of the dynamics of these changes in the hippocampus are the necessary first steps toward understanding molecular pathways responsible for the development of post-stroke cognitive impairments and mental pathologies.

KW - cognitive impairment

KW - depression

KW - focal brain injuries

KW - gene expression

KW - hippocampus

KW - neuroinflammation

KW - Stroke/complications

KW - Mental Disorders/etiology

KW - Humans

KW - Gene Expression Regulation

KW - Cognition Disorders/etiology

KW - Cognition

KW - Inflammation

KW - Animals

KW - Brain Ischemia/complications

KW - Brain Injuries

KW - Hippocampus/metabolism

KW - Depression/etiology

UR - http://www.scopus.com/inward/record.url?scp=85106915160&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=46793866

U2 - 10.1134/S0006297921060043

DO - 10.1134/S0006297921060043

M3 - Review article

C2 - 34225589

AN - SCOPUS:85106915160

VL - 86

SP - 657

EP - 666

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 6

M1 - 3

ER -

ID: 34441748