Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress

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Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress. / Zhanaeva, S. Ya; Rogozhnikova, A. A.; Alperina, E. L. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 164, No. 4, 01.03.2018, p. 425-429.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{4e9e333650294473af4f3db5d28af000,

title = "Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress",

abstract = "We studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations. In mice with aggressive behavior, protease activity in the studied brain structures was not changed. In 4 h after immune system activation with LPS (250 μg/kg), cathepsin L activity in the hippocampus of control mice increased in comparison with mice receiving saline. In contrast to control animals, LPS caused a decrease in activity of the enzyme in the caudate nucleus and frontal cortex of aggressive mice and in the hippocampus of mice with depressive-like behavior.",

keywords = "aggressive and depressive-like behavior, brain structures, cathepsins B and L, chronic social stress, INHIBITION, ALZHEIMERS-DISEASE, MODEL, ASSOCIATION, DEFICIENCY",

author = "Zhanaeva, {S. Ya} and Rogozhnikova, {A. A.} and Alperina, {E. L.} and Gevorgyan, {M. M.} and Idov, {G. V.}",

year = "2018",

month = mar,

day = "1",

doi = "10.1007/s10517-018-4004-2",

language = "English",

volume = "164",

pages = "425--429",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer New York",

number = "4",

}

RIS

TY - JOUR

T1 - Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress

AU - Zhanaeva, S. Ya

AU - Rogozhnikova, A. A.

AU - Alperina, E. L.

AU - Gevorgyan, M. M.

AU - Idov, G. V.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - We studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations. In mice with aggressive behavior, protease activity in the studied brain structures was not changed. In 4 h after immune system activation with LPS (250 μg/kg), cathepsin L activity in the hippocampus of control mice increased in comparison with mice receiving saline. In contrast to control animals, LPS caused a decrease in activity of the enzyme in the caudate nucleus and frontal cortex of aggressive mice and in the hippocampus of mice with depressive-like behavior.

AB - We studied activity of lysosomal cysteine proteases, cathepsins B and L, in brain structures (frontal cortex, caudate nucleus, hippocampus, and hypothalamus) of C57Bl/6J mice with aggressive and depressive-like behavior formed under conditions of chronic social stress (repeated experience of victories and defeats within 20 days). Mice with depressive-like behavior showed increased activity of cathepsin В in the hypothalamus and nucleus caudatus and increased activity of cathepsin L in the hippocampus compared to control animals not subjected to agonistic confrontations. In mice with aggressive behavior, protease activity in the studied brain structures was not changed. In 4 h after immune system activation with LPS (250 μg/kg), cathepsin L activity in the hippocampus of control mice increased in comparison with mice receiving saline. In contrast to control animals, LPS caused a decrease in activity of the enzyme in the caudate nucleus and frontal cortex of aggressive mice and in the hippocampus of mice with depressive-like behavior.

KW - aggressive and depressive-like behavior

KW - brain structures

KW - cathepsins B and L

KW - chronic social stress

KW - INHIBITION

KW - ALZHEIMERS-DISEASE

KW - MODEL

KW - ASSOCIATION

KW - DEFICIENCY

UR - http://www.scopus.com/inward/record.url?scp=85043762743&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4004-2

DO - 10.1007/s10517-018-4004-2

M3 - Article

C2 - 29500808

AN - SCOPUS:85043762743

VL - 164

SP - 425

EP - 429

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 4

ER -

ID: 12079321