Central Regulatory Circuit of the Drosophila Mechanoreceptor Morphogenesis System: Effects of Mutations

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Central Regulatory Circuit of the Drosophila Mechanoreceptor Morphogenesis System: Effects of Mutations. / Furman, D. P.; Bukharina, T. A.; Golubyatnikov, V. P.

In: Journal of Applied and Industrial Mathematics, Vol. 17, No. 3, 09.2023, p. 535-543.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{6b8fe0fef80b4b938d603f89b563ddc1,

title = "Central Regulatory Circuit of the Drosophila Mechanoreceptor Morphogenesis System: Effects of Mutations",

abstract = "We describe a mathematical model of the functioning of the central regulatory circuit ofgene networks for the morphogenesis of Drosophila mechanoreceptors taking into accountmutations of the genes included in it. Computational experiments have been carried out showingthe existence of a hierarchy of effects of CRC gene mutations on the production of ASC proteins.",

keywords = "Drosophila, achaete-scute complex, central regulatory circuit, computer modeling, gene network, mathematical model, mutation, parameter identification",

author = "Furman, {D. P.} and Bukharina, {T. A.} and Golubyatnikov, {V. P.}",

note = "This work was carried out within the framework of the state task for the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, project no. FWNR-2022-0020, and the state task for the Sobolev Institute of Mathematics of the Siberian Branch of the Russian Academy of Sciences, project no. FWNF-2022-0009. Публикация для корректировки.",

year = "2023",

month = sep,

doi = "10.1134/S1990478923030079",

language = "English",

volume = "17",

pages = "535--543",

journal = "Journal of Applied and Industrial Mathematics",

issn = "1990-4789",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "3",

}

RIS

TY - JOUR

T1 - Central Regulatory Circuit of the Drosophila Mechanoreceptor Morphogenesis System: Effects of Mutations

AU - Furman, D. P.

AU - Bukharina, T. A.

AU - Golubyatnikov, V. P.

N1 - This work was carried out within the framework of the state task for the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, project no. FWNR-2022-0020, and the state task for the Sobolev Institute of Mathematics of the Siberian Branch of the Russian Academy of Sciences, project no. FWNF-2022-0009. Публикация для корректировки.

PY - 2023/9

Y1 - 2023/9

N2 - We describe a mathematical model of the functioning of the central regulatory circuit ofgene networks for the morphogenesis of Drosophila mechanoreceptors taking into accountmutations of the genes included in it. Computational experiments have been carried out showingthe existence of a hierarchy of effects of CRC gene mutations on the production of ASC proteins.

AB - We describe a mathematical model of the functioning of the central regulatory circuit ofgene networks for the morphogenesis of Drosophila mechanoreceptors taking into accountmutations of the genes included in it. Computational experiments have been carried out showingthe existence of a hierarchy of effects of CRC gene mutations on the production of ASC proteins.

KW - Drosophila

KW - achaete-scute complex

KW - central regulatory circuit

KW - computer modeling

KW - gene network

KW - mathematical model

KW - mutation

KW - parameter identification

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85175822228&origin=inward&txGid=99a6724a0792807b4a5dd954e7519d44

UR - https://www.mendeley.com/catalogue/6e367e5a-1482-3570-a656-66e37a8223bb/

U2 - 10.1134/S1990478923030079

DO - 10.1134/S1990478923030079

M3 - Article

VL - 17

SP - 535

EP - 543

JO - Journal of Applied and Industrial Mathematics

JF - Journal of Applied and Industrial Mathematics

SN - 1990-4789

IS - 3

ER -

ID: 59553989