Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial

Standard

Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial. / Lomivorotov, Vladimir; Ponomarev, Dmitry; Boboshko, Vladimir et al.

In: Contemporary Clinical Trials Communications, Vol. 23, 100835, 09.2021.

Research output: Contribution to journal › Article › peer-review

Harvard

Lomivorotov, V, Ponomarev, D, Boboshko, V, Shmyrev, V, Ismoilov, S, Efremov, S, Kamenshchikov, N, Akselrod, B, Pasyuga, V, Urusov, D, Ovezov, A, Evdokimov, M, Turchaninov, A, Bogachev-Prokofiev, A, Bukamal, N, Afifi, S, Belletti, A, Bellomo, R & Landoni, G 2021, 'Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial', Contemporary Clinical Trials Communications, vol. 23, 100835. https://doi.org/10.1016/j.conctc.2021.100835

APA

Lomivorotov, V., Ponomarev, D., Boboshko, V., Shmyrev, V., Ismoilov, S., Efremov, S., Kamenshchikov, N., Akselrod, B., Pasyuga, V., Urusov, D., Ovezov, A., Evdokimov, M., Turchaninov, A., Bogachev-Prokofiev, A., Bukamal, N., Afifi, S., Belletti, A., Bellomo, R., & Landoni, G. (2021). Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial. Contemporary Clinical Trials Communications, 23, [100835]. https://doi.org/10.1016/j.conctc.2021.100835

Vancouver

Lomivorotov V, Ponomarev D, Boboshko V, Shmyrev V, Ismoilov S, Efremov S et al. Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial. Contemporary Clinical Trials Communications. 2021 Sept;23:100835. doi: 10.1016/j.conctc.2021.100835

Author

Lomivorotov, Vladimir ; Ponomarev, Dmitry ; Boboshko, Vladimir et al. / Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial. In: Contemporary Clinical Trials Communications. 2021 ; Vol. 23.

BibTeX

@article{98e4db96c76445a9b717d9b161ee5ad5,

title = "Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial",

abstract = "Introduction: Weaning from cardiopulmonary bypass (CPB) is a critical step of any cardiac surgical procedure and often requires pharmacologic intervention. Calcium ions are pivotal elements for the excitation-contraction coupling process of cardiac myocytes. Thus, calcium administration might be helpful during weaning from CPB. Methods: We describe a multicenter, placebo-controlled, double blind randomized clinical trial to assess the effect of calcium chloride on the need for inotropic support among adult patients during weaning from CPB. The experimental group (409 patients) will receive 15 mg/kg of calcium chloride. The control group (409 patients) will receive an equivalent volume of 0.9% sodium chloride. Both drugs will be administered intravenously as a bolus at the beginning of weaning from CPB. Results: The primary outcome will be the need for inotropic support between termination of CPB and completion of surgery. Secondary outcomes will be: duration of inotropic support, vasoactive-inotropic score 30 min after transfer to intensive care unit and on postoperative day 1, plasma alpha-amylase on postoperative day 1, plasma Ca2+ concentration immediately before and 10–15 min after calcium chloride administration, non-fatal myocardial infarction, blood loss on postoperative day 1, need for transfusion of red blood cells, signs of myocardial ischemia on electrocardiogram after arrival to intensive care unit, all-cause mortality at 30 days or during hospital stay if this is longer than 30 days. Discussion: This trial is designed to assess whether intravenous calcium chloride administration could reduce the need for inotropic support after cardiopulmonary bypass weaning among adults undergoing cardiac surgery.",

keywords = "Calcium chloride, Cardiac surgery, Cardiopulmonary bypass, Hypocalcemia, Inotropic support",

author = "Vladimir Lomivorotov and Dmitry Ponomarev and Vladimir Boboshko and Vladimir Shmyrev and Samandar Ismoilov and Sergey Efremov and Nikolay Kamenshchikov and Boris Akselrod and Vadim Pasyuga and Dmitry Urusov and Alexey Ovezov and Mikhail Evdokimov and Alexander Turchaninov and Alexander Bogachev-Prokofiev and Nazar Bukamal and Sarah Afifi and Alessandro Belletti and Rinaldo Bellomo and Giovanni Landoni",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = sep,

doi = "10.1016/j.conctc.2021.100835",

language = "English",

volume = "23",

journal = "Contemporary Clinical Trials Communications",

issn = "2451-8654",

publisher = "Elsevier Science Publishing Company, Inc.",

}

RIS

TY - JOUR

T1 - Calcium administration In patients undergoing CardiAc suRgery under cardiopulmonary bypasS (ICARUS trial): Rationale and design of a randomized controlled trial

AU - Lomivorotov, Vladimir

AU - Ponomarev, Dmitry

AU - Boboshko, Vladimir

AU - Shmyrev, Vladimir

AU - Ismoilov, Samandar

AU - Efremov, Sergey

AU - Kamenshchikov, Nikolay

AU - Akselrod, Boris

AU - Pasyuga, Vadim

AU - Urusov, Dmitry

AU - Ovezov, Alexey

AU - Evdokimov, Mikhail

AU - Turchaninov, Alexander

AU - Bogachev-Prokofiev, Alexander

AU - Bukamal, Nazar

AU - Afifi, Sarah

AU - Belletti, Alessandro

AU - Bellomo, Rinaldo

AU - Landoni, Giovanni

PY - 2021/9

Y1 - 2021/9

N2 - Introduction: Weaning from cardiopulmonary bypass (CPB) is a critical step of any cardiac surgical procedure and often requires pharmacologic intervention. Calcium ions are pivotal elements for the excitation-contraction coupling process of cardiac myocytes. Thus, calcium administration might be helpful during weaning from CPB. Methods: We describe a multicenter, placebo-controlled, double blind randomized clinical trial to assess the effect of calcium chloride on the need for inotropic support among adult patients during weaning from CPB. The experimental group (409 patients) will receive 15 mg/kg of calcium chloride. The control group (409 patients) will receive an equivalent volume of 0.9% sodium chloride. Both drugs will be administered intravenously as a bolus at the beginning of weaning from CPB. Results: The primary outcome will be the need for inotropic support between termination of CPB and completion of surgery. Secondary outcomes will be: duration of inotropic support, vasoactive-inotropic score 30 min after transfer to intensive care unit and on postoperative day 1, plasma alpha-amylase on postoperative day 1, plasma Ca2+ concentration immediately before and 10–15 min after calcium chloride administration, non-fatal myocardial infarction, blood loss on postoperative day 1, need for transfusion of red blood cells, signs of myocardial ischemia on electrocardiogram after arrival to intensive care unit, all-cause mortality at 30 days or during hospital stay if this is longer than 30 days. Discussion: This trial is designed to assess whether intravenous calcium chloride administration could reduce the need for inotropic support after cardiopulmonary bypass weaning among adults undergoing cardiac surgery.

AB - Introduction: Weaning from cardiopulmonary bypass (CPB) is a critical step of any cardiac surgical procedure and often requires pharmacologic intervention. Calcium ions are pivotal elements for the excitation-contraction coupling process of cardiac myocytes. Thus, calcium administration might be helpful during weaning from CPB. Methods: We describe a multicenter, placebo-controlled, double blind randomized clinical trial to assess the effect of calcium chloride on the need for inotropic support among adult patients during weaning from CPB. The experimental group (409 patients) will receive 15 mg/kg of calcium chloride. The control group (409 patients) will receive an equivalent volume of 0.9% sodium chloride. Both drugs will be administered intravenously as a bolus at the beginning of weaning from CPB. Results: The primary outcome will be the need for inotropic support between termination of CPB and completion of surgery. Secondary outcomes will be: duration of inotropic support, vasoactive-inotropic score 30 min after transfer to intensive care unit and on postoperative day 1, plasma alpha-amylase on postoperative day 1, plasma Ca2+ concentration immediately before and 10–15 min after calcium chloride administration, non-fatal myocardial infarction, blood loss on postoperative day 1, need for transfusion of red blood cells, signs of myocardial ischemia on electrocardiogram after arrival to intensive care unit, all-cause mortality at 30 days or during hospital stay if this is longer than 30 days. Discussion: This trial is designed to assess whether intravenous calcium chloride administration could reduce the need for inotropic support after cardiopulmonary bypass weaning among adults undergoing cardiac surgery.

KW - Calcium chloride

KW - Cardiac surgery

KW - Cardiopulmonary bypass

KW - Hypocalcemia

KW - Inotropic support

UR - http://www.scopus.com/inward/record.url?scp=85122673129&partnerID=8YFLogxK

U2 - 10.1016/j.conctc.2021.100835

DO - 10.1016/j.conctc.2021.100835

M3 - Article

C2 - 34485754

AN - SCOPUS:85122673129

VL - 23

JO - Contemporary Clinical Trials Communications

JF - Contemporary Clinical Trials Communications

SN - 2451-8654

M1 - 100835

ER -

ID: 35259861