Research output: Contribution to journal › Article › peer-review
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. / The ENIGMA-MDD DTI Working Group.
In: Molecular Psychiatry, Vol. 26, No. 9, 09.2021, p. 5124-5139.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
AU - The ENIGMA-MDD DTI Working Group
AU - Han, Laura K.M.
AU - Dinga, Richard
AU - Hahn, Tim
AU - Ching, Christopher R.K.
AU - Eyler, Lisa T.
AU - Aftanas, Lyubomir
AU - Aghajani, Moji
AU - Aleman, André
AU - Baune, Bernhard T.
AU - Berger, Klaus
AU - Brak, Ivan
AU - Filho, Geraldo Busatto
AU - Carballedo, Angela
AU - Connolly, Colm G.
AU - Couvy-Duchesne, Baptiste
AU - Cullen, Kathryn R.
AU - Dannlowski, Udo
AU - Davey, Christopher G.
AU - Dima, Danai
AU - Duran, Fabio L.S.
AU - Enneking, Verena
AU - Filimonova, Elena
AU - Frenzel, Stefan
AU - Frodl, Thomas
AU - Fu, Cynthia H.Y.
AU - Godlewska, Beata R.
AU - Gotlib, Ian H.
AU - Grabe, Hans J.
AU - Groenewold, Nynke A.
AU - Grotegerd, Dominik
AU - Gruber, Oliver
AU - Hall, Geoffrey B.
AU - Harrison, Ben J.
AU - Hatton, Sean N.
AU - Hermesdorf, Marco
AU - Hickie, Ian B.
AU - Ho, Tiffany C.
AU - Hosten, Norbert
AU - Jansen, Andreas
AU - Kähler, Claas
AU - Kircher, Tilo
AU - Klimes-Dougan, Bonnie
AU - Krämer, Bernd
AU - Krug, Axel
AU - Lagopoulos, Jim
AU - Leenings, Ramona
AU - MacMaster, Frank P.
AU - MacQueen, Glenda
AU - McIntosh, Andrew
AU - McLellan, Quinn
PY - 2021/9
Y1 - 2021/9
N2 - Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.
AB - Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted “brain age” and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen’s d = 0.14, 95% CI: 0.08–0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aging
KW - Brain/diagnostic imaging
KW - Depressive Disorder, Major
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Young Adult
UR - http://www.scopus.com/inward/record.url?scp=85085208849&partnerID=8YFLogxK
U2 - 10.1038/s41380-020-0754-0
DO - 10.1038/s41380-020-0754-0
M3 - Article
C2 - 32424236
AN - SCOPUS:85085208849
VL - 26
SP - 5124
EP - 5139
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
IS - 9
ER -
ID: 24396612