Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients

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Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients. / Ermakov, E. A.; Ivanova, S. A.; Buneva, V. N. et al.

In: Biochemistry (Moscow), Vol. 83, No. 5, 01.05.2018, p. 507-526.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{bdc8ed904e2140fe807e3d17c6091b73,

title = "Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients",

abstract = "Abzymes with various catalytic activities are the earliest statistically significant markers of existing and developing autoimmune diseases (AIDs). Currently, schizophrenia (SCZD) is not considered to be a typical AID. It was demonstrated recently that antibodies from SCZD patients efficiently hydrolyze DNA and myelin basic protein. Here, we showed for the first time that autoantibodies from 35 SCZD patients efficiently hydrolyze RNA (cCMP > poly(C) > poly(A) > yeast RNA) and analyzed site-specific hydrolysis of microRNAs involved in the regulation of several genes in SCZD (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p). All four microRNAs were cleaved by IgG preparations (n = 21) from SCZD patients in a site-specific manner. The RNase activity of the abzymes correlated with SCZD clinical parameters. The data obtained showed that SCZD patients might display signs of typical autoimmune processes associated with impaired functioning of microRNAs resulting from their hydrolysis by the abzymes.",

keywords = "abzymes, miRNA hydrolysis, polyribonucleotide, schizophrenia patients",

author = "Ermakov, {E. A.} and Ivanova, {S. A.} and Buneva, {V. N.} and Nevinsky, {G. A.}",

note = "Publisher Copyright: {\textcopyright} 2018, Pleiades Publishing, Ltd.",

year = "2018",

month = may,

day = "1",

doi = "10.1134/S0006297918050048",

language = "English",

volume = "83",

pages = "507--526",

journal = "Biochemistry (Moscow)",

issn = "0006-2979",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "5",

}

RIS

TY - JOUR

T1 - Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients

AU - Ermakov, E. A.

AU - Ivanova, S. A.

AU - Buneva, V. N.

AU - Nevinsky, G. A.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Abzymes with various catalytic activities are the earliest statistically significant markers of existing and developing autoimmune diseases (AIDs). Currently, schizophrenia (SCZD) is not considered to be a typical AID. It was demonstrated recently that antibodies from SCZD patients efficiently hydrolyze DNA and myelin basic protein. Here, we showed for the first time that autoantibodies from 35 SCZD patients efficiently hydrolyze RNA (cCMP > poly(C) > poly(A) > yeast RNA) and analyzed site-specific hydrolysis of microRNAs involved in the regulation of several genes in SCZD (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p). All four microRNAs were cleaved by IgG preparations (n = 21) from SCZD patients in a site-specific manner. The RNase activity of the abzymes correlated with SCZD clinical parameters. The data obtained showed that SCZD patients might display signs of typical autoimmune processes associated with impaired functioning of microRNAs resulting from their hydrolysis by the abzymes.

AB - Abzymes with various catalytic activities are the earliest statistically significant markers of existing and developing autoimmune diseases (AIDs). Currently, schizophrenia (SCZD) is not considered to be a typical AID. It was demonstrated recently that antibodies from SCZD patients efficiently hydrolyze DNA and myelin basic protein. Here, we showed for the first time that autoantibodies from 35 SCZD patients efficiently hydrolyze RNA (cCMP > poly(C) > poly(A) > yeast RNA) and analyzed site-specific hydrolysis of microRNAs involved in the regulation of several genes in SCZD (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p). All four microRNAs were cleaved by IgG preparations (n = 21) from SCZD patients in a site-specific manner. The RNase activity of the abzymes correlated with SCZD clinical parameters. The data obtained showed that SCZD patients might display signs of typical autoimmune processes associated with impaired functioning of microRNAs resulting from their hydrolysis by the abzymes.

KW - abzymes

KW - miRNA hydrolysis

KW - polyribonucleotide

KW - schizophrenia patients

UR - http://www.scopus.com/inward/record.url?scp=85047263657&partnerID=8YFLogxK

U2 - 10.1134/S0006297918050048

DO - 10.1134/S0006297918050048

M3 - Article

C2 - 29738685

AN - SCOPUS:85047263657

VL - 83

SP - 507

EP - 526

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 5

ER -

ID: 13487060