TY - JOUR

T1 - Biological testing of titanium-containing implants with noble metal coatings in an in vivo experiment

AU - Zheravin, Alexander

AU - Dorovskikh, Svetlana I.

AU - Vikulova, Eugenia S.

AU - Basova, Tamara V.

AU - Vasileva, Maria B.

AU - Rusakova, Yanina L.

AU - Morozova, Nataliya B.

N1 - Биологическое тестирование никелидтитановых имплантатов с покрытиями из благородных металлов в эксперименте in vivo / А.А. Жеравин, С.И. Доровских, Е.С. Викулова [и др.] // Сибирский онкологический журнал. – 2024. – Т. 23. - № 5. – С. 73-84. Работа выполнена при финансовой поддержке РНФ, проект № 20-15-00222-П.

PY - 2024/10

Y1 - 2024/10

N2 - The aim of study is to conduct in vivo biological testing of titanium nickelide samples modified with Ag/Pt or AuAg/Pt film heterostructures in comparison with the bare carrier. Material and Methods. Titanium nickelide plates modified with film heterostructures made of noble metals and the laboratory mini-pigs used for in vivo tests were the objects of the study. To form film structures on titanium nickelide samples, the physical gas-phase deposition methods: ion plasma deposition (IPD) and thermal (PVD) sputtering were used. The Ag/ Pt or AuAg/Pt heterostructures were characterized by X-ray diffraction and scanning microscopy methods. Results. The biocompatibility of implants before (TiNi, control) and after (Ag/Pt/TiNi and AuAg/Pt/TiNi) modification with film heterostructures was tested in in-vivo experiments on a laboratory animal (mini-pig). General toxic reactions of the body to the injected samples were absent. A comparative macroscopic and histological analysis of the condition of peri-implant tissues after 39 days of implantation was performed. The connective tissue capsule around the TiNi sample revealed the presence of a certain number of lymphocytes, eosinophils and macrophages, but these indicators decrease in the order of TiNi > AuAg/Pt/TiNi > Ag/Pt/TiNi. Conclusion. The positive effect of modifying the titanium nickelide surfaces with noble metal heterostructures on the biocompatibility of metal implants was demonstrated in an in vivo experiment.

AB - The aim of study is to conduct in vivo biological testing of titanium nickelide samples modified with Ag/Pt or AuAg/Pt film heterostructures in comparison with the bare carrier. Material and Methods. Titanium nickelide plates modified with film heterostructures made of noble metals and the laboratory mini-pigs used for in vivo tests were the objects of the study. To form film structures on titanium nickelide samples, the physical gas-phase deposition methods: ion plasma deposition (IPD) and thermal (PVD) sputtering were used. The Ag/ Pt or AuAg/Pt heterostructures were characterized by X-ray diffraction and scanning microscopy methods. Results. The biocompatibility of implants before (TiNi, control) and after (Ag/Pt/TiNi and AuAg/Pt/TiNi) modification with film heterostructures was tested in in-vivo experiments on a laboratory animal (mini-pig). General toxic reactions of the body to the injected samples were absent. A comparative macroscopic and histological analysis of the condition of peri-implant tissues after 39 days of implantation was performed. The connective tissue capsule around the TiNi sample revealed the presence of a certain number of lymphocytes, eosinophils and macrophages, but these indicators decrease in the order of TiNi > AuAg/Pt/TiNi > Ag/Pt/TiNi. Conclusion. The positive effect of modifying the titanium nickelide surfaces with noble metal heterostructures on the biocompatibility of metal implants was demonstrated in an in vivo experiment.

KW - X-ray study

KW - antibacterial agent

KW - coating

KW - gold

KW - histological study

KW - implant

KW - implantation

KW - platinum

KW - silver

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85211102684&origin=inward&txGid=74c7293cc8b1fa5f7d17063f4d7d8e97

UR - https://www.elibrary.ru/item.asp?id=75144785

UR - https://www.mendeley.com/catalogue/c44ee993-d801-357a-9dde-1f4cd59a21b2/

U2 - 10.21294/1814-4861-2024-23-5-73-84

DO - 10.21294/1814-4861-2024-23-5-73-84

M3 - Article

VL - 23

SP - 73

EP - 84

JO - Siberian Journal of Oncology

JF - Siberian Journal of Oncology

SN - 1814-4861

IS - 5

M1 - 7

ER -