TY - JOUR

T1 - Bidirectional Mendelian randomization analysis of back pain and 22 associated factors

AU - Елгаева, Елизавета Евгеньевна

AU - Williams, Frances M.K.

AU - Зайцева, Ольга Олеговна

AU - Freidin, Maxim B.

AU - Aulchenko, Yurii S.

AU - Цепилов, Яков Александрович

AU - Suri, Pradeep

N1 - Conference code: 56

PY - 2024/1

Y1 - 2024/1

N2 - Background/Objectives: Epidemiological observations established associations between back pain (BP) and multiple factors. However, it is unknown if these associations are causal. To address this issue, we performed a bidirectional Mendelian randomization (MR) study to examine causal relationships between BP and 22 putative risk factors.Methods: We utilized public data for BP and 22 risk factors from the largest GWAS performed in Europeans to conduct MR analysis using inverse-variance weighted meta-analysis (IVW), Causal Analysis Using Summary Effect (CAUSE) and sensitivity analyses. We considered the findings concordant with a hypothesis of causality if results of IVW or CAUSE were statistically significant (p Results: We found statistically significant causal relationships between education (OR = 0.54 [0.51,0.58] per ~4 years of schooling), smoking (OR = 1.20 [1.15,1.26]), alcohol consumption (OR = 1.28 [1.19,1.39]), sleep duration (OR = 0.75 [0.63,0.89]), depression (OR = 1.37 [1.25,1.50]), diastolic (OR = 1.10 [1.04,1.17]) and systolic blood pressure (OR = 1.09 [1.04,1.15]), neuroticism (OR = 1.51 [1.37,1.67]), BMI (OR = 1.14 [1.05,1.23]) and BP risk. We also observed a significant causal influence of BP on depression (OR = 1.28 [1.12,1.47]), neuroticism (beta MR = 0.12) and type 2 diabetes (OR = 1.40 [1.13,1.73]).Conclusion: We clarified causal relationships between BP and associated factors. Fewer years of schooling, smoking, increased alcohol intake, less sleep, higher blood pressure and greater BMI increase BP risk. Conversely, BP causes type 2 diabetes, depression and neuroticism. These findings may facilitate BP management improvement.Grant References: YAT and EEE were supported by RSF grant #22-15-20037 and Government of the Novosibirsk region. Dr. Suri was funded by NIAMS/NIH P30AR072572 and VA I01RX004291.Conflict of Interest: Elizaveta Elgaeva: None declared, Frances Williams: None declared, Olga Zaytseva: None declared, Maxim Freidin: None declared, Yurii Aulchenko YSA is a cofounder and co-owner of PolyOmica and PolyKnomics, private organizations providing services, research, and development in the field of computational and statistical genomics., Yakov Tsepilov: None declared, Pradeep Suri: None declared.

AB - Background/Objectives: Epidemiological observations established associations between back pain (BP) and multiple factors. However, it is unknown if these associations are causal. To address this issue, we performed a bidirectional Mendelian randomization (MR) study to examine causal relationships between BP and 22 putative risk factors.Methods: We utilized public data for BP and 22 risk factors from the largest GWAS performed in Europeans to conduct MR analysis using inverse-variance weighted meta-analysis (IVW), Causal Analysis Using Summary Effect (CAUSE) and sensitivity analyses. We considered the findings concordant with a hypothesis of causality if results of IVW or CAUSE were statistically significant (p Results: We found statistically significant causal relationships between education (OR = 0.54 [0.51,0.58] per ~4 years of schooling), smoking (OR = 1.20 [1.15,1.26]), alcohol consumption (OR = 1.28 [1.19,1.39]), sleep duration (OR = 0.75 [0.63,0.89]), depression (OR = 1.37 [1.25,1.50]), diastolic (OR = 1.10 [1.04,1.17]) and systolic blood pressure (OR = 1.09 [1.04,1.15]), neuroticism (OR = 1.51 [1.37,1.67]), BMI (OR = 1.14 [1.05,1.23]) and BP risk. We also observed a significant causal influence of BP on depression (OR = 1.28 [1.12,1.47]), neuroticism (beta MR = 0.12) and type 2 diabetes (OR = 1.40 [1.13,1.73]).Conclusion: We clarified causal relationships between BP and associated factors. Fewer years of schooling, smoking, increased alcohol intake, less sleep, higher blood pressure and greater BMI increase BP risk. Conversely, BP causes type 2 diabetes, depression and neuroticism. These findings may facilitate BP management improvement.Grant References: YAT and EEE were supported by RSF grant #22-15-20037 and Government of the Novosibirsk region. Dr. Suri was funded by NIAMS/NIH P30AR072572 and VA I01RX004291.Conflict of Interest: Elizaveta Elgaeva: None declared, Frances Williams: None declared, Olga Zaytseva: None declared, Maxim Freidin: None declared, Yurii Aulchenko YSA is a cofounder and co-owner of PolyOmica and PolyKnomics, private organizations providing services, research, and development in the field of computational and statistical genomics., Yakov Tsepilov: None declared, Pradeep Suri: None declared.

UR - https://www.nature.com/articles/s41431-023-01481-y

M3 - Conference article

VL - 32

SP - 346

JO - European journal of human genetics

JF - European journal of human genetics

SN - 1018-4813

IS - S1

M1 - EP25.008

T2 - 56th Annual Conference of the European-Society-of-Human-Genetics (ESHG)

Y2 - 10 June 2023 through 13 June 2023

ER -