Benzopentathiepine derivative, 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), as a promising antidepressant of new generation

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Benzopentathiepine derivative, 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), as a promising antidepressant of new generation. / Kulikova, Elizabeth A.; Volcho, Konstantin P.; Salakhutdinov, Nariman F. et al.

In: Letters in Drug Design and Discovery, Vol. 14, No. 8, 01.08.2017, p. 974-984.

Research output: Contribution to journal › Review article › peer-review

BibTeX

@article{45424af3bf8244fd89a25a4ee37415b1,

title = "Benzopentathiepine derivative, 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), as a promising antidepressant of new generation",

abstract = "Background: Depressive disorders are among four leading causes of burden among the most disabling medical illnesses and antidepressant drugs (AD) occupying leading positions in the worldwide pharmaceutical market. However, typical AD show prolonged delay, refractory and adverse side effects. Methodology: The review analyzes experimental data and theoretical models of possible antidepressant effect of benzopentathiepine, 8-(trifluoromethyl)-1,2,3,4,5 - benzopentathiepin-6- amine hydrochloride (TC-2153). The antidepressant effect of TC-2153 is based on its ability to inhibit striatal enriched protein tyrosine phosphatase (STEP)- an enzyme that plays a key role in the intraneuronal transduction of signals from receptors of classic neurotransmitters and the brain derived neurotrophic factor (BDNF). The mechanism underlying antidepressant effect of TC-2153 includes increase in production as well as intracellular effect of BDNF on neuronal survival and neurogenesis. Results and Conclusion: There is no visible mechanisms of delay, refractory and adverse side effects of TC-2153. Thus, TC-2153 is a promising drug of new generation of atypical AD.",

keywords = "Antidepressant, BDNF, depression, serotonin, STEP, TC-2153",

author = "Kulikova, {Elizabeth A.} and Volcho, {Konstantin P.} and Salakhutdinov, {Nariman F.} and Kulikov, {Alexander V.}",

note = "Publisher Copyright: {\textcopyright} 2017 Bentham Science Publishers.",

year = "2017",

month = aug,

day = "1",

doi = "10.2174/1570180814666161121112417",

language = "English",

volume = "14",

pages = "974--984",

journal = "Letters in Drug Design and Discovery",

issn = "1570-1808",

publisher = "Bentham Science Publishers B.V.",

number = "8",

}

RIS

TY - JOUR

T1 - Benzopentathiepine derivative, 8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), as a promising antidepressant of new generation

AU - Kulikova, Elizabeth A.

AU - Volcho, Konstantin P.

AU - Salakhutdinov, Nariman F.

AU - Kulikov, Alexander V.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: Depressive disorders are among four leading causes of burden among the most disabling medical illnesses and antidepressant drugs (AD) occupying leading positions in the worldwide pharmaceutical market. However, typical AD show prolonged delay, refractory and adverse side effects. Methodology: The review analyzes experimental data and theoretical models of possible antidepressant effect of benzopentathiepine, 8-(trifluoromethyl)-1,2,3,4,5 - benzopentathiepin-6- amine hydrochloride (TC-2153). The antidepressant effect of TC-2153 is based on its ability to inhibit striatal enriched protein tyrosine phosphatase (STEP)- an enzyme that plays a key role in the intraneuronal transduction of signals from receptors of classic neurotransmitters and the brain derived neurotrophic factor (BDNF). The mechanism underlying antidepressant effect of TC-2153 includes increase in production as well as intracellular effect of BDNF on neuronal survival and neurogenesis. Results and Conclusion: There is no visible mechanisms of delay, refractory and adverse side effects of TC-2153. Thus, TC-2153 is a promising drug of new generation of atypical AD.

AB - Background: Depressive disorders are among four leading causes of burden among the most disabling medical illnesses and antidepressant drugs (AD) occupying leading positions in the worldwide pharmaceutical market. However, typical AD show prolonged delay, refractory and adverse side effects. Methodology: The review analyzes experimental data and theoretical models of possible antidepressant effect of benzopentathiepine, 8-(trifluoromethyl)-1,2,3,4,5 - benzopentathiepin-6- amine hydrochloride (TC-2153). The antidepressant effect of TC-2153 is based on its ability to inhibit striatal enriched protein tyrosine phosphatase (STEP)- an enzyme that plays a key role in the intraneuronal transduction of signals from receptors of classic neurotransmitters and the brain derived neurotrophic factor (BDNF). The mechanism underlying antidepressant effect of TC-2153 includes increase in production as well as intracellular effect of BDNF on neuronal survival and neurogenesis. Results and Conclusion: There is no visible mechanisms of delay, refractory and adverse side effects of TC-2153. Thus, TC-2153 is a promising drug of new generation of atypical AD.

KW - Antidepressant

KW - BDNF

KW - depression

KW - serotonin

KW - STEP

KW - TC-2153

UR - http://www.scopus.com/inward/record.url?scp=85027871768&partnerID=8YFLogxK

U2 - 10.2174/1570180814666161121112417

DO - 10.2174/1570180814666161121112417

M3 - Review article

AN - SCOPUS:85027871768

VL - 14

SP - 974

EP - 984

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

SN - 1570-1808

IS - 8

ER -

ID: 8969037