TY - JOUR

T1 - Beam shaping assembly design of 7Li(p,n)7Be neutron source for boron neutron capture therapy of deep-seated tumor

AU - Zaidi, L.

AU - Belgaid, M.

AU - Taskaev, S.

AU - Khelifi, R.

N1 - Publisher Copyright: © 2018 Elsevier Ltd

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The development of a medical facility for boron neutron capture therapy at Budker Institute of Nuclear Physics is under way. The neutron source is based on a tandem accelerator with vacuum insulation and lithium target. The proposed accelerator is conceived to deliver a proton beam around 10 mA at 2.3 MeV proton beam. To deliver a therapeutic beam for treatment of deep-seated tumors a typical Beam Shaping Assembly (BSA) based on the source specifications has been explored. In this article, an optimized BSA based on the 7Li(p,n)7Be neutron production reaction is proposed. To evaluate the performance of the designed beam in a phantom, the parameters and the dose profiles in tissues due to the irradiation have been considered. In the simulations, we considered a proton energy of 2.3 MeV, a current of 10 mA, and boron concentrations in tumor, healthy tissues and skin of 52.5 ppm, 15 ppm and 22.5 ppm, respectively. It is found that, for a maximum punctual healthy tissue dose seated to 11 RBE-Gy, a mean dose of 56.5 RBE Gy with a minimum of 52.2 RBE Gy can be delivered to a tumor in 40 min, where the therapeutic ratio is estimated to 5.38. All of these calculations were carried out using the Monte Carlo MCNP code.

AB - The development of a medical facility for boron neutron capture therapy at Budker Institute of Nuclear Physics is under way. The neutron source is based on a tandem accelerator with vacuum insulation and lithium target. The proposed accelerator is conceived to deliver a proton beam around 10 mA at 2.3 MeV proton beam. To deliver a therapeutic beam for treatment of deep-seated tumors a typical Beam Shaping Assembly (BSA) based on the source specifications has been explored. In this article, an optimized BSA based on the 7Li(p,n)7Be neutron production reaction is proposed. To evaluate the performance of the designed beam in a phantom, the parameters and the dose profiles in tissues due to the irradiation have been considered. In the simulations, we considered a proton energy of 2.3 MeV, a current of 10 mA, and boron concentrations in tumor, healthy tissues and skin of 52.5 ppm, 15 ppm and 22.5 ppm, respectively. It is found that, for a maximum punctual healthy tissue dose seated to 11 RBE-Gy, a mean dose of 56.5 RBE Gy with a minimum of 52.2 RBE Gy can be delivered to a tumor in 40 min, where the therapeutic ratio is estimated to 5.38. All of these calculations were carried out using the Monte Carlo MCNP code.

KW - Li(p,n)Be neutron generator reaction

KW - Accelerator-based BNCT

KW - Beam shaping assembly

KW - In-phantom parameters

KW - Li-7(p,n)Be-7 neutron generator reaction

KW - TARGET

KW - FACILITY

KW - ACCELERATOR-BASED BNCT

KW - I CLINICAL-TRIAL

KW - BSA

KW - REACTION NEAR-THRESHOLD

KW - OPTIMIZATION

KW - DOSIMETRY

KW - Humans

KW - Glioblastoma/radiotherapy

KW - Radioisotopes

KW - Lithium/radiation effects

KW - Beryllium/radiation effects

KW - Equipment Design

KW - Computer Simulation

KW - Radiotherapy Planning, Computer-Assisted

KW - Boron Neutron Capture Therapy/instrumentation

KW - Radiotherapy Dosage

KW - Brain Neoplasms/radiotherapy

KW - Phantoms, Imaging

UR - http://www.scopus.com/inward/record.url?scp=85048134202&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2018.05.029

DO - 10.1016/j.apradiso.2018.05.029

M3 - Article

C2 - 29890472

AN - SCOPUS:85048134202

VL - 139

SP - 316

EP - 324

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

ER -