TY - JOUR

T1 - Base Excision DNA Repair in Plants: Arabidopsis and Beyond

AU - Grin, Inga R

AU - Petrova, Daria V

AU - Endutkin, Anton V

AU - Ma, Chunquan

AU - Yu, Bing

AU - Li, Haiying

AU - Zharkov, Dmitry O

N1 - This research was funded by a joint grant from the Russian Science Foundation (23-44-00050) and the International Cooperation and Exchange of the National Science Foundation of China Project (32261133530). Sequence analysis of DML and TAG protein families was supported by the Russian Ministry of Science and Education (project 12103130056-8).

PY - 2023/9/29

Y1 - 2023/9/29

N2 - Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living organisms from damage caused by both intrinsic and environmental factors. Most present knowledge about BER comes from studies of human cells, E. coli, and yeast. Plants may be under an even heavier DNA damage threat from abiotic stress, reactive oxygen species leaking from the photosynthetic system, and reactive secondary metabolites. In general, BER in plant species is similar to that in humans and model organisms, but several important details are specific to plants. Here, we review the current state of knowledge about BER in plants, with special attention paid to its unique features, such as the existence of active epigenetic demethylation based on the BER machinery, the unexplained diversity of alkylation damage repair enzymes, and the differences in the processing of abasic sites that appear either spontaneously or are generated as BER intermediates. Understanding the biochemistry of plant DNA repair, especially in species other than the Arabidopsis model, is important for future efforts to develop new crop varieties.

AB - Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living organisms from damage caused by both intrinsic and environmental factors. Most present knowledge about BER comes from studies of human cells, E. coli, and yeast. Plants may be under an even heavier DNA damage threat from abiotic stress, reactive oxygen species leaking from the photosynthetic system, and reactive secondary metabolites. In general, BER in plant species is similar to that in humans and model organisms, but several important details are specific to plants. Here, we review the current state of knowledge about BER in plants, with special attention paid to its unique features, such as the existence of active epigenetic demethylation based on the BER machinery, the unexplained diversity of alkylation damage repair enzymes, and the differences in the processing of abasic sites that appear either spontaneously or are generated as BER intermediates. Understanding the biochemistry of plant DNA repair, especially in species other than the Arabidopsis model, is important for future efforts to develop new crop varieties.

KW - DNA damage

KW - DNA repair

KW - base excision repair

KW - plants

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85174698337&origin=inward&txGid=da540e14bf4452d4736631fce59f9e1c

UR - https://www.mendeley.com/catalogue/8b59f512-12a8-3cd1-b31f-8a1f9435a784/

U2 - 10.3390/ijms241914746

DO - 10.3390/ijms241914746

M3 - Review article

C2 - 37834194

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 19

M1 - 14746

ER -