Research output: Contribution to journal › Article › peer-review
Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis. / Polonskaya, Ya V.; Shramko, V. S.; Morozov, S. V. et al.
In: Bulletin of Experimental Biology and Medicine, Vol. 164, No. 1, 01.11.2017, p. 33-35.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis
AU - Polonskaya, Ya V.
AU - Shramko, V. S.
AU - Morozov, S. V.
AU - Chernyak, E. I.
AU - Chernyavsky, A. M.
AU - Ragino, Y. I.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - We studied the balance of fatty acids and their correlation with parameters of lipid metabolism and inflammation markers in men with coronary atherosclerosis. In the blood of patients and healthy men, the content of myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), stearic (C18:0), arachidic (C20:0) and docosanic (C22:0), TNFα, IL-1β, IL-6, IL-8, C-reactive protein, cholesterol, triglycerides, HDL, and LPO intensity were measured. In patients with coronary atherosclerosis, increased concentrations of saturated fatty acids, triglycerides, LPO products, IL-6, IL-8, and C-reactive protein were found. Correlation analysis revealed multiple correlations between the studied fatty acids, correlation of C16:0, C18:0, and C20:0 with inflammation markers, C14:0, C16:0, and C18:0 with triglyceride level, C16:0, C18:0, and C20:0 with cholesterol. The contents of C14:0, C15:0, C16:0, and C18:0 correlated with the presence of coronary atherosclerosis. Lipid metabolism disturbances in coronary atherosclerosis were accompanied by changes in not only lipid spectrum and inflammation markers, but also fatty acids balance.
AB - We studied the balance of fatty acids and their correlation with parameters of lipid metabolism and inflammation markers in men with coronary atherosclerosis. In the blood of patients and healthy men, the content of myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), stearic (C18:0), arachidic (C20:0) and docosanic (C22:0), TNFα, IL-1β, IL-6, IL-8, C-reactive protein, cholesterol, triglycerides, HDL, and LPO intensity were measured. In patients with coronary atherosclerosis, increased concentrations of saturated fatty acids, triglycerides, LPO products, IL-6, IL-8, and C-reactive protein were found. Correlation analysis revealed multiple correlations between the studied fatty acids, correlation of C16:0, C18:0, and C20:0 with inflammation markers, C14:0, C16:0, and C18:0 with triglyceride level, C16:0, C18:0, and C20:0 with cholesterol. The contents of C14:0, C15:0, C16:0, and C18:0 correlated with the presence of coronary atherosclerosis. Lipid metabolism disturbances in coronary atherosclerosis were accompanied by changes in not only lipid spectrum and inflammation markers, but also fatty acids balance.
KW - coronary atherosclerosis
KW - fatty acids
KW - inflammation markers
KW - lipid metabolism
KW - MIDDLE-AGED ADULTS
KW - RISK
UR - http://www.scopus.com/inward/record.url?scp=85033397602&partnerID=8YFLogxK
U2 - 10.1007/s10517-017-3920-x
DO - 10.1007/s10517-017-3920-x
M3 - Article
C2 - 29119389
AN - SCOPUS:85033397602
VL - 164
SP - 33
EP - 35
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 1
ER -
ID: 9952819