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Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin. / Taskaeva, Iu S.; Bgatova, N. P.; Solovieva, A. O.

In: Cell and Tissue Biology, Vol. 13, No. 5, 01.09.2019, p. 353-359.

Research output: Contribution to journal › Article › peer-review

Harvard

Taskaeva, IS, Bgatova, NP & Solovieva, AO 2019, 'Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin', Cell and Tissue Biology, vol. 13, no. 5, pp. 353-359. https://doi.org/10.1134/S1990519X19050079

APA

Taskaeva, I. S., Bgatova, N. P., & Solovieva, A. O. (2019). Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin. Cell and Tissue Biology, 13(5), 353-359. https://doi.org/10.1134/S1990519X19050079

Vancouver

Taskaeva IS, Bgatova NP, Solovieva AO. Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin. Cell and Tissue Biology. 2019 Sept 1;13(5):353-359. doi: 10.1134/S1990519X19050079

Author

Taskaeva, Iu S. ; Bgatova, N. P. ; Solovieva, A. O. / Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin. In: Cell and Tissue Biology. 2019 ; Vol. 13, No. 5. pp. 353-359.

BibTeX

@article{01cd3633a6a3480db98b415571f9b5e9,
title = "Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin",
abstract = "Abstract: The role of autophagy in the development and progression of hepatocellular carcinoma (HCC) is ambiguous and still little known. Autophagy stimulation may be of exceptional interest in antitumor pharmacotherapy of HCC. Rapamycin and lithium are typical inducers of autophagy. The aim of this study was to compare the level of autophagy in hepatocellular carcinoma-29 (HCC-29) cells after single and combined administration of lithium carbonate and rapamycin. Autolysosomes formation and significant increase of LC3 beta (+)– and LAMP1 (+)– autophagic structures were revealed in HCC-29 cells after lithium carbonate and rapamycin coadministration by transmission electron microscopy and immunofluorescence analysis. Using this combination of drugs may be a promising strategy for HCC chemotherapy, since it will allow the integration of various cellular signaling pathways that regulate autophagy and apoptosis in tumor cells.",
keywords = "autophagy, hepatocellular carcinoma-29, lithium carbonate, rapamycin",
author = "Taskaeva, {Iu S.} and Bgatova, {N. P.} and Solovieva, {A. O.}",
year = "2019",
month = sep,
day = "1",
doi = "10.1134/S1990519X19050079",
language = "English",
volume = "13",
pages = "353--359",
journal = "Cell and Tissue Biology",
issn = "1990-519X",
publisher = "Pleiades Publishing",
number = "5",

}

RIS

TY - JOUR

T1 - Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin

AU - Taskaeva, Iu S.

AU - Bgatova, N. P.

AU - Solovieva, A. O.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Abstract: The role of autophagy in the development and progression of hepatocellular carcinoma (HCC) is ambiguous and still little known. Autophagy stimulation may be of exceptional interest in antitumor pharmacotherapy of HCC. Rapamycin and lithium are typical inducers of autophagy. The aim of this study was to compare the level of autophagy in hepatocellular carcinoma-29 (HCC-29) cells after single and combined administration of lithium carbonate and rapamycin. Autolysosomes formation and significant increase of LC3 beta (+)– and LAMP1 (+)– autophagic structures were revealed in HCC-29 cells after lithium carbonate and rapamycin coadministration by transmission electron microscopy and immunofluorescence analysis. Using this combination of drugs may be a promising strategy for HCC chemotherapy, since it will allow the integration of various cellular signaling pathways that regulate autophagy and apoptosis in tumor cells.

AB - Abstract: The role of autophagy in the development and progression of hepatocellular carcinoma (HCC) is ambiguous and still little known. Autophagy stimulation may be of exceptional interest in antitumor pharmacotherapy of HCC. Rapamycin and lithium are typical inducers of autophagy. The aim of this study was to compare the level of autophagy in hepatocellular carcinoma-29 (HCC-29) cells after single and combined administration of lithium carbonate and rapamycin. Autolysosomes formation and significant increase of LC3 beta (+)– and LAMP1 (+)– autophagic structures were revealed in HCC-29 cells after lithium carbonate and rapamycin coadministration by transmission electron microscopy and immunofluorescence analysis. Using this combination of drugs may be a promising strategy for HCC chemotherapy, since it will allow the integration of various cellular signaling pathways that regulate autophagy and apoptosis in tumor cells.

KW - autophagy

KW - hepatocellular carcinoma-29

KW - lithium carbonate

KW - rapamycin

UR - http://www.scopus.com/inward/record.url?scp=85073616645&partnerID=8YFLogxK

U2 - 10.1134/S1990519X19050079

DO - 10.1134/S1990519X19050079

M3 - Article

AN - SCOPUS:85073616645

VL - 13

SP - 353

EP - 359

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - 5

ER -

ID: 21938976