TY - JOUR

T1 - Automated Volumetric Analysis of Postoperative Magnetic Resonance Imaging Predicts Survival in Patients with Glioblastoma

AU - Krivoshapkin, Alexey L.

AU - Sergeev, Gleb S.

AU - Gaytan, Alekey S.

AU - Kalneus, Leonid E.

AU - Kurbatov, Vladislav P.

AU - Abdullaev, Orkhan A.

AU - Salim, Nidal

AU - Bulanov, Dmitry V.

AU - Simonovich, Alexander E.

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background: Glioblastomas (GBMs) are primary brain tumors that are very difficult to treat. Magnetic resonance imaging (MRI) is the reference tool for diagnosis, postoperative control, and follow-up of GBM. The MRI tumor contrast enhancement part serves as a target for surgery. However, there are controversial data about the influence of pre- and postoperative tumor volumetric MRI parameters on overall survival (OS). Methods: Data of 57 patients with GBM were analyzed retrospectively. All patients had maximum safe resection and standard adjuvant treatment. All patients underwent 1.5-T MRI with contrast in the first 24 hours postoperatively. The data of pre- and postoperative volumetric parameters were analyzed using the original software. Results: Correlation analysis between the postoperative volume of the tumor contrast enhancement part and the patient's OS revealed a significant level (on the Chaddock scale) of inverse correlation. Residual tumor volume associated with OS of >6 months was determined as <2.5 cm3. The mortality risk in the first 6 months after tumor resection is 3.4 times higher when the tumor remnant is >2.5 cm3 (risk ratio, 3.4; P = 0.0002). Conclusions: The volume of MRI contrast-enhancing GBM remnants after surgery, automatically measured by the software, was a significant predictor for early postoperative progression and death.

AB - Background: Glioblastomas (GBMs) are primary brain tumors that are very difficult to treat. Magnetic resonance imaging (MRI) is the reference tool for diagnosis, postoperative control, and follow-up of GBM. The MRI tumor contrast enhancement part serves as a target for surgery. However, there are controversial data about the influence of pre- and postoperative tumor volumetric MRI parameters on overall survival (OS). Methods: Data of 57 patients with GBM were analyzed retrospectively. All patients had maximum safe resection and standard adjuvant treatment. All patients underwent 1.5-T MRI with contrast in the first 24 hours postoperatively. The data of pre- and postoperative volumetric parameters were analyzed using the original software. Results: Correlation analysis between the postoperative volume of the tumor contrast enhancement part and the patient's OS revealed a significant level (on the Chaddock scale) of inverse correlation. Residual tumor volume associated with OS of >6 months was determined as <2.5 cm3. The mortality risk in the first 6 months after tumor resection is 3.4 times higher when the tumor remnant is >2.5 cm3 (risk ratio, 3.4; P = 0.0002). Conclusions: The volume of MRI contrast-enhancing GBM remnants after surgery, automatically measured by the software, was a significant predictor for early postoperative progression and death.

KW - Glioblastoma management

KW - Gross total resection

KW - MRI evaluation

KW - Software for MRI

KW - Volumetric tumor estimation

KW - SURGERY

KW - PROGNOSTIC-FACTORS

KW - RESECTION

KW - MULTIFORME

KW - MALIGNANT GLIOMA

KW - EXTENT

KW - CENTRAL-NERVOUS-SYSTEM

KW - RESIDUAL TUMOR

UR - http://www.scopus.com/inward/record.url?scp=85064324019&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2019.03.142

DO - 10.1016/j.wneu.2019.03.142

M3 - Article

C2 - 30910753

AN - SCOPUS:85064324019

VL - 126

SP - e1510-e1517

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

ER -