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Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death. / Ivanova, A. A.; Maksimov, V. N.; Ivanoshchuk, D. E. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 163, No. 1, 01.05.2017, p. 73-77.

Research output: Contribution to journal › Article › peer-review

Harvard

Ivanova, AA, Maksimov, VN, Ivanoshchuk, DE, Orlov, PS, Novoselov, VP, Savchenko, SV & Voevoda, MI 2017, 'Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death', Bulletin of Experimental Biology and Medicine, vol. 163, no. 1, pp. 73-77. https://doi.org/10.1007/s10517-017-3741-y

APA

Ivanova, A. A., Maksimov, V. N., Ivanoshchuk, D. E., Orlov, P. S., Novoselov, V. P., Savchenko, S. V., & Voevoda, M. I. (2017). Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death. Bulletin of Experimental Biology and Medicine, 163(1), 73-77. https://doi.org/10.1007/s10517-017-3741-y

Vancouver

Ivanova AA, Maksimov VN, Ivanoshchuk DE, Orlov PS, Novoselov VP, Savchenko SV et al. Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death. Bulletin of Experimental Biology and Medicine. 2017 May 1;163(1):73-77. doi: 10.1007/s10517-017-3741-y

Author

Ivanova, A. A. ; Maksimov, V. N. ; Ivanoshchuk, D. E. et al. / Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death. In: Bulletin of Experimental Biology and Medicine. 2017 ; Vol. 163, No. 1. pp. 73-77.

BibTeX

@article{ffe47a28b91c4744812119318480446c,
title = "Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death",
abstract = "We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group.",
keywords = "GJA5, KCNN3, SCN5A, single-nucleotide polymorphism, sudden cardiac death",
author = "Ivanova, {A. A.} and Maksimov, {V. N.} and Ivanoshchuk, {D. E.} and Orlov, {P. S.} and Novoselov, {V. P.} and Savchenko, {S. V.} and Voevoda, {M. I.}",
year = "2017",
month = may,
day = "1",
doi = "10.1007/s10517-017-3741-y",
language = "English",
volume = "163",
pages = "73--77",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death

AU - Ivanova, A. A.

AU - Maksimov, V. N.

AU - Ivanoshchuk, D. E.

AU - Orlov, P. S.

AU - Novoselov, V. P.

AU - Savchenko, S. V.

AU - Voevoda, M. I.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group.

AB - We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group.

KW - GJA5

KW - KCNN3

KW - SCN5A

KW - single-nucleotide polymorphism

KW - sudden cardiac death

UR - http://www.scopus.com/inward/record.url?scp=85020132159&partnerID=8YFLogxK

U2 - 10.1007/s10517-017-3741-y

DO - 10.1007/s10517-017-3741-y

M3 - Article

C2 - 28577096

AN - SCOPUS:85020132159

VL - 163

SP - 73

EP - 77

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 8843850