TY - JOUR

T1 - Association between the effects of high temperature on fertility and sleep in female intra-specific hybrids of Drosophila melanogaster

AU - Zakharenko, Lyudmila P.

AU - Petrovskii, Dmitriy V.

AU - Dorogova, Nataliya V.

AU - Putilov, Arcady A.

N1 - Funding Information: Funding: L.P.Z., N.V.D., and D.V.P. were partially funded by the Federal Research Program (project number 0259-2021-0016). A.A.P. was supported by a grant from the Russian Foundation for Basic Research (grant number19-013-00424). Publisher Copyright: © 2021 by the authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - Humans and fruit flies demonstrate similarity in sleep-wake behavior, e.g., in the pattern of sleep disturbances caused by an exposure to high temperature. Although research has provided evidence for a clear connection between sleeping problems and infertility in women, very little is known regarding the mechanisms underlying this connection. Studies of dysgenic crosses of fruit flies revealed that an exposure to elevated temperature induces sterility in female intra-specific hybrids exclusively in one of two cross directions (progeny of Canton-S females crossed with Harwich males). Given the complexity and limitations of human studies, this fruit flies’ model of temperature-sensitive sterility might be used for testing whether the effects of high temperature on fertility and on 24-h sleep pattern are inter-related. To document this pattern, 315 hybrids were kept for at least five days in constant darkness at 20 °C and 29 °C. No evidence was found for a causal link between sterility and sleep disturbance. However, a diminished thermal responsiveness of sleep was shown by females with temperature-induced sterility, while significant responses to high temperature were still observed in fertile females obtained by crossing in the opposite direction (i.e., Canton-S males with Harwich females) and in fertile males from either cross.

AB - Humans and fruit flies demonstrate similarity in sleep-wake behavior, e.g., in the pattern of sleep disturbances caused by an exposure to high temperature. Although research has provided evidence for a clear connection between sleeping problems and infertility in women, very little is known regarding the mechanisms underlying this connection. Studies of dysgenic crosses of fruit flies revealed that an exposure to elevated temperature induces sterility in female intra-specific hybrids exclusively in one of two cross directions (progeny of Canton-S females crossed with Harwich males). Given the complexity and limitations of human studies, this fruit flies’ model of temperature-sensitive sterility might be used for testing whether the effects of high temperature on fertility and on 24-h sleep pattern are inter-related. To document this pattern, 315 hybrids were kept for at least five days in constant darkness at 20 °C and 29 °C. No evidence was found for a causal link between sterility and sleep disturbance. However, a diminished thermal responsiveness of sleep was shown by females with temperature-induced sterility, while significant responses to high temperature were still observed in fertile females obtained by crossing in the opposite direction (i.e., Canton-S males with Harwich females) and in fertile males from either cross.

KW - Fruit fly model

KW - Infertility

KW - Reproductive health

KW - Sleep disorders

UR - http://www.scopus.com/inward/record.url?scp=85104559038&partnerID=8YFLogxK

U2 - 10.3390/insects12040336

DO - 10.3390/insects12040336

M3 - Article

C2 - 33918720

AN - SCOPUS:85104559038

VL - 12

JO - Insects

JF - Insects

SN - 2075-4450

IS - 4

M1 - 336

ER -