Assessment of the degree of skin hypopigmentation in patients with vitiligo by using mexametry. / Deeva, N. V.; Krinitsyna, Yu M.; Mustafina, S. V. et al.
In: Open Dermatology Journal, Vol. 11, No. 1, 01.01.2017, p. 53-58.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Assessment of the degree of skin hypopigmentation in patients with vitiligo by using mexametry
AU - Deeva, N. V.
AU - Krinitsyna, Yu M.
AU - Mustafina, S. V.
AU - Rymar, O. D.
AU - Sergeeva, I. G.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - This study is an assessment of the degree of skin hypopigmentation in patients with vitiligo. Material and Methods: The study followed 47 patients with vitiligo (33 female and 14 male patients; the average age was 38.0 ± 18.0 years). The mean disease duration was 15.5 ± 14.1 years. We determined the melanin levels in the patches of vitiligo and on the healthy skin of the face, trunk, and extremities by using mexametry. Results: High melanin levels were found in patches on and around the mouth. Melanin levels did not differ in vitiligo patches and on healthy skin of chins and buttocks. All patients had no melanin in the patches on their cheeks. Having vitiligo for a long time reduces melanin levels in the skin of the forehead. High melanin levels in healthy skin are associated with stored melanin in vitiligo patches in axillary areas, on the back, brachiums, and femurs. Conclusions: There are significant differences in the melanin levels in the vitiligo patches and healthy skin, which have specific features depending on the localization. Analysis of melanin levels may be useful in choosing a method and evaluating the effectiveness of the planned therapy.
AB - This study is an assessment of the degree of skin hypopigmentation in patients with vitiligo. Material and Methods: The study followed 47 patients with vitiligo (33 female and 14 male patients; the average age was 38.0 ± 18.0 years). The mean disease duration was 15.5 ± 14.1 years. We determined the melanin levels in the patches of vitiligo and on the healthy skin of the face, trunk, and extremities by using mexametry. Results: High melanin levels were found in patches on and around the mouth. Melanin levels did not differ in vitiligo patches and on healthy skin of chins and buttocks. All patients had no melanin in the patches on their cheeks. Having vitiligo for a long time reduces melanin levels in the skin of the forehead. High melanin levels in healthy skin are associated with stored melanin in vitiligo patches in axillary areas, on the back, brachiums, and femurs. Conclusions: There are significant differences in the melanin levels in the vitiligo patches and healthy skin, which have specific features depending on the localization. Analysis of melanin levels may be useful in choosing a method and evaluating the effectiveness of the planned therapy.
KW - Hypopigmentation
KW - Melanin
KW - Melanin levels
KW - Mexametry
KW - Skin
KW - Vitiligo
UR - http://www.scopus.com/inward/record.url?scp=85052516885&partnerID=8YFLogxK
U2 - 10.2174/1874372201711010053
DO - 10.2174/1874372201711010053
M3 - Article
AN - SCOPUS:85052516885
VL - 11
SP - 53
EP - 58
JO - Open Dermatology Journal
JF - Open Dermatology Journal
SN - 1874-3722
IS - 1
ER -
ID: 16409977