Research output: Contribution to journal › Article › peer-review
Assessment of the biocompatibility of cucurbiturils in blood cells. / Aktanova, Alina; Abramova, Tatjana; Pashkina, Ekaterina et al.
In: Nanomaterials, Vol. 11, No. 6, 1356, 06.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Assessment of the biocompatibility of cucurbiturils in blood cells
AU - Aktanova, Alina
AU - Abramova, Tatjana
AU - Pashkina, Ekaterina
AU - Boeva, Olga
AU - Grishina, Lyubov
AU - Kovalenko, Ekaterina
AU - Kozlov, Vladimir
N1 - Funding Information: This study was funded by the Russian Science Foundation, according to research project number 19-15-00192. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6
Y1 - 2021/6
N2 - Currently, cucurbiturils are being actively researched all over the world. Research is focused on the ways of improving the solubility and selectivity of cucurbiturils, increasing the stability of the complexes with other particles in various media and enhancing their ability to bind and release various substances. The most significant area of our research is the assessment of safety, studying the biological properties and synergistic effects of cucurbiturils during complexation with drugs. In this article, the hemocompatibility of erythrocytes and leukocytes with cucurbiturils was investigated. We demonstrated that cucurbiturils have no cytotoxic effect, even at high concentrations (1 mM) and do not affect the viability of PBMCs. However, cucurbiturils can increase the level of the early apoptosis of lymphocytes and cucurbit[7]uril enhances hemolysis in biologically relevant media. Despite this, cucurbiturils are fairly safe organic molecules in concentrations up to 0.3 mM. Thus, we believe that it will become possible to use polymer nanostructures as drug delivery systems in clinical practice, since cucurbiturils can be modified to improve pharmacological properties.
AB - Currently, cucurbiturils are being actively researched all over the world. Research is focused on the ways of improving the solubility and selectivity of cucurbiturils, increasing the stability of the complexes with other particles in various media and enhancing their ability to bind and release various substances. The most significant area of our research is the assessment of safety, studying the biological properties and synergistic effects of cucurbiturils during complexation with drugs. In this article, the hemocompatibility of erythrocytes and leukocytes with cucurbiturils was investigated. We demonstrated that cucurbiturils have no cytotoxic effect, even at high concentrations (1 mM) and do not affect the viability of PBMCs. However, cucurbiturils can increase the level of the early apoptosis of lymphocytes and cucurbit[7]uril enhances hemolysis in biologically relevant media. Despite this, cucurbiturils are fairly safe organic molecules in concentrations up to 0.3 mM. Thus, we believe that it will become possible to use polymer nanostructures as drug delivery systems in clinical practice, since cucurbiturils can be modified to improve pharmacological properties.
KW - Apoptosis
KW - Cucurbiturils
KW - Cytotoxicity
KW - Hemolysis
KW - Immunosafety
KW - Nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85106247347&partnerID=8YFLogxK
U2 - 10.3390/nano11061356
DO - 10.3390/nano11061356
M3 - Article
C2 - 34063763
AN - SCOPUS:85106247347
VL - 11
JO - Nanomaterials
JF - Nanomaterials
SN - 2079-4991
IS - 6
M1 - 1356
ER -
ID: 34034247