Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues

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Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues. / Vasilyeva, Svetlana V.; Petrova, Albina S.; Shtil, Alexander A. et al.

In: Journal of Saudi Chemical Society, Vol. 24, No. 1, 01.2020, p. 98-104.

Research output: Contribution to journal › Article › peer-review

Author

Vasilyeva, Svetlana V. ; Petrova, Albina S. ; Shtil, Alexander A. et al. / Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues. In: Journal of Saudi Chemical Society. 2020 ; Vol. 24, No. 1. pp. 98-104.

BibTeX

@article{53e1016c4ab7414687579b44b78c1b04,

title = "Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues",

abstract = "A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.",

keywords = "Colon cancer cells, Cycloaddition reaction, Phosphorylated nucleoside analogues, SiO nanoparticles, Tumor-targeting ligands",

author = "Vasilyeva, {Svetlana V.} and Petrova, {Albina S.} and Shtil, {Alexander A.} and Stetsenko, {Dmitry A.}",

year = "2020",

month = jan,

doi = "10.1016/j.jscs.2019.09.007",

language = "English",

volume = "24",

pages = "98--104",

journal = "Journal of Saudi Chemical Society",

issn = "1319-6103",

publisher = "King Saud University",

number = "1",

}

RIS

TY - JOUR

T1 - Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues

AU - Vasilyeva, Svetlana V.

AU - Petrova, Albina S.

AU - Shtil, Alexander A.

AU - Stetsenko, Dmitry A.

PY - 2020/1

Y1 - 2020/1

N2 - A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.

AB - A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.

KW - Colon cancer cells

KW - Cycloaddition reaction

KW - Phosphorylated nucleoside analogues

KW - SiO nanoparticles

KW - Tumor-targeting ligands

UR - http://www.scopus.com/inward/record.url?scp=85073007150&partnerID=8YFLogxK

U2 - 10.1016/j.jscs.2019.09.007

DO - 10.1016/j.jscs.2019.09.007

M3 - Article

AN - SCOPUS:85073007150

VL - 24

SP - 98

EP - 104

JO - Journal of Saudi Chemical Society

JF - Journal of Saudi Chemical Society

SN - 1319-6103

IS - 1

ER -

ID: 21861699